Change in psychosocial functioning and social relations among women in residential substance abuse treatment

Knight, Danica K.; Wallace, Gail; Joe, George W.; Logan, Sarah M.

doi:10.1016/s0899-3289(01)00087-6

Cited by 18 publications

(15 citation statements)

References 36 publications

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“…The current effects of AMPH exposure on pair bonding are consistent with previous studies illustrating the deleterious effects of psychostimulants on other social behaviors, including maternal behavior (45)(46)(47) and social play (48)(49)(50). Together, such work provides the promise that examination of how drug and social stimuli interact in the brain may significantly extend our understanding of the strong interactions between social behavior and drug use in humans (21).…”

Section: Discussionsupporting

confidence: 85%

“…The intense impact on this circuit by these and other addictive drugs has been suggested to decrease the perceived value of natural incentives (20), including those of a social nature (8). Although it is known that drug addicts show impaired social behavior (21), the neural regulation of interactions between drug experience and social attachment is poorly understood. This is because, in part, such interactions are difficult to model in traditional laboratory rodents that do not exhibit social bonding between adult conspecifics.…”

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confidence: 99%

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Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Liang

Aragona

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

119

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The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating, a behavior in which central dopamine (DA) has been implicated. Here, we used male prairie voles to examine the effects of drug exposure on pair bonding and related neural circuitry. In our first experiment, amphetamine (AMPH) motivated behavior was examined using a conditioned place preference (CPP) paradigm and was shown to be mediated by activation of D1-like DA receptors. Next, we examined the effects of repeated AMPH exposure on pair bonding. Intact and saline pretreated control males displayed mating-induced partner preferences, whereas males pretreated with AMPH at the doses effective to induce CPP failed to show mating-induced partner preferences. Such AMPH treatment also enhanced D1, but not D2, DA receptor expression in the nucleus accumbens (NAcc). Furthermore, pharmacological blockade of D1-like DA receptors in the NAcc rescued mating-induced partner preferences in AMPH-treated males. Together, our data indicate that repeated AMPH exposure may narrow the behavioral repertoire of male prairie voles via a DA receptor-specific mechanism in the NAcc, resulting in the impairment of pair bond formation.vole | CPP | D1 Receptor I t is widely accepted that motivated and emotional behaviors that promote fitness are regulated by brain reward circuitry including the mesolimbic dopamine (DA) system (1, 2). Although this system is often implicated in food intake and sexual behavior (3, 4), it has also been implicated in other naturally occurring motivated behaviors, such as social play between juveniles and social bonding between parent and offspring (5-9). Often underrepresented in research are the social bonds formed between adult mates, i.e., pair bonds. Recent investigation using a socially monogamous rodent species, the prairie vole (Microtus ochrogaster) (10-12), indicate that a great deal of the neural regulation underlying pair bond formation and maintenance occurs within the nucleus accumbens (NAcc) (13-15)-a mesolimbic brain region critical for mediating motivated behaviors (1, 2, 16).Although motivational circuitry evolved to promote fitness enhancing behavior such as feeding, mating, and social bonding (1, 17), it is vulnerable to artificial usurpation by drugs of abuse (8). For example, administration of psychostimulant drugs of abuse, such as cocaine and amphetamine (AMPH), results in persistent alterations of mesolimbic DA activity (18,19). The intense impact on this circuit by these and other addictive drugs has been suggested to decrease the perceived value of natural incentives (20), including those of a social nature (8). Although it is known that drug addicts show impaired social behavior (21), the neural regulation of interactions between drug experience and social attachment is poorly understood. This is because, in part, such interactions are difficult to model in traditional laboratory rodents that do not exhibit social bonding between adult conspecifics.The neurobiology of su...

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Section: Discussionsupporting

confidence: 85%

mentioning

confidence: 99%

Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Liang

Aragona

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

119

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“…In fact, it has been suggested that individuals with impoverished social environments may be more likely to artificially stimulate these neural pathways [40,45] and that social support may reduce addictive urges [44]. This is supported by studies showing that a positive social environment is beneficial for recovery from drug addiction [30,31]. Future studies will directly test if pair bonded voles are 'protected' against drug reward and hopefully improve treatment and prevention of drug addiction.…”

Section: Discussionmentioning

confidence: 98%

“…Included among these are genetic predisposition and drug availability, variables that have been well modeled with traditional laboratory rodents and that have been shown to greatly influence drug seeking behavior [1,18,22,59]. However, there are other complexities known to influence drug taking in humans, such as social environment [31]. This variable is more difficult to study in the laboratory because traditional rodent subjects do not exhibit social organization analogous to that shown by humans [4].…”

Section: Introductionmentioning

confidence: 99%

Amphetamine reward in the monogamous prairie vole

Aragona¹,

Detwiler²,

Wang³

2007

Neuroscience Letters

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Recent studies have shown that the neural regulation of pair bonding in the monogamous prairie vole (Microtus ochrogaster) is similar to that of drug seeking in more traditional laboratory rodents. Therefore, strong interactions between social behavior and drug reward can be expected. Here, we established the prairie vole as a model for drug studies by demonstrating robust amphetamineinduced conditioned place preferences in this species. For both males and females, the effects of amphetamine were dose-dependent, with females being more sensitive to drug treatment. This study represents the first evidence of drug reward in this species. Future studies will examine the effects of social behavior on drug reward and the underlying neurobiology of such interactions.Keywords drug abuse; addiction; conditioned place preference; attachment; social bonding; monogamy There are many factors that contribute to drug abuse. Included among these are genetic predisposition and drug availability, variables that have been well modeled with traditional laboratory rodents and that have been shown to greatly influence drug seeking behavior [1,18,22,59]. However, there are other complexities known to influence drug taking in humans, such as social environment [31]. This variable is more difficult to study in the laboratory because traditional rodent subjects do not exhibit social organization analogous to that shown by humans [4]. Studies in non-human primates demonstrate the importance of social hierarchy on drug taking [39]. However, primate experiments are not practical for most laboratories and therefore understanding the neurobiology of interactions between social behavior and drug abuse would be greatly facilitated if it were studied in rodent models. Here, we have taken an initial step toward this end by establishing a highly social rodent species, the monogamous prairie vole (Microtus ochrogaster), for drug studies.The prairie vole is a powerful model for studies of social attachment [13,23]. Males and females of this species show preferential mating with one partner [20], exhibit high levels of parental behavior [36][37][38]43], and form enduring pair bonds, which are maintained even if one member of the pair is lost [57]. Pair bond formation is routinely studied in the laboratory by using a partner preference test [60,61] and such studies have provided excellent insight into the neural regulation of pair bonding [62]. In particular, recent studies have shown that pair bond formation and maintenance critically depend on key components of brain reward circuitry, Correspondence to: Zuoxin Wang, Ph.D., Department of Psychology, Florida State University, Tallahassee, FL 32306-1270, Phone: 850-644-5057, Fax: 850-644-7739, E-mail: E-mail: zwang@psy.fsu.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the res...

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“…For example, the development of a strong social support network has been identified as a mechanism of change for participants involved in mutual-help groups such as Alcoholics Anonymous (AA; Groh, Jason, & Keys, 2008). Social support also leads to better outcomes in formal SUD treatment (Kidorf et al, 2005; Knight, Wallace, Joe, & Logan, 2001). Further, social support networks consisting of sober friends and family are a robust predictor of sustained abstinence (Litt, Kadden, Tennen, & Kabela-Cormier, 2016; Stout, Kelly, Magill, & Pagano, 2012).…”

Section: Introductionmentioning

confidence: 99%

Interpersonal styles, peer relationships, and outcomes in residential substance use treatment

Harrison

Timko

Blonigen

2017

Journal of Substance Abuse Treatment

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Interpersonal relationships play a key role in recovery from substance use disorders (SUDs). We examined the associations between problematic interpersonal styles, peer relationships, and treatment outcomes in a sample of U.S. military veterans in residential SUD treatment. Participants were 189 veterans enrolled in a residential SUD treatment program at a Department of Veterans Affairs medical center. Participants were interviewed at the time of treatment entry (baseline), one month into treatment, and 12 months following discharge from treatment. More problematic interpersonal styles at treatment entry, measured by the Inventory of Interpersonal Problems-Circumplex (IIP-C), predicted more SUD symptoms 12 months post-discharge (r=.29, P<.01). Results of a principal components analysis of the IIP-C subscales revealed three main factors of interpersonal styles: Passive, Cruel/Aloof, and Controlling. With the exception of the Passive factor, the relationship between these interpersonal styles and SUD symptoms 12 months after discharge was mediated by relationship quality with peers one month in treatment: i.e., more problematic interpersonal styles at baseline predicted poorer relationship quality with peers at 1 month, which in turn predicted more SUD symptoms at 12 months. Results demonstrate the importance of assessing interpersonal styles among patients in residential SUD treatment, as well as potentially augmenting existing evidence-based psychosocial treatments with a focus on interpersonal styles.

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Change in psychosocial functioning and social relations among women in residential substance abuse treatment

Cited by 18 publications

References 36 publications

Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Amphetamine reward in the monogamous prairie vole

Interpersonal styles, peer relationships, and outcomes in residential substance use treatment

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