Change in sex ratio with exposure to dioxin

“…Following the Seveso accident in Italy in 1976, where a wide area was contaminated with dioxin, the secondary sex ratio (the male/female ratio at birth) was found to decline among the exposed population [4]. This discovery led to an increased focus on the potential of organochlorines to alter the sex ratio and maternal exposure to other organochlorines, i.e.…”

Section: Introductionmentioning

confidence: 99%

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

Timmermann¹,

Choi

Petersen

et al. 2017

International Journal of Circumpolar Health

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This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother–child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p’-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0–16%), 7% (95% CI = 0–14%) and 9% (95% CI = 2–17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention.

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“…Exposure to dioxins, which include polychlorinated dibenzo-para -dioxins (PCDDs), polychlorinated dibenzofurans ( PCDFs ), and coplanar polychlorinated biphenyls ( PCBs ), has been associated with adverse health outcomes in humans, including increased cancer incidence and mortality (IARC, 1997;Kogevinas, 2001 ), as well as effects on cardiovascular system (Bertazzi et al, 1989(Bertazzi et al, , 2001, reproductive system ( Egeland et al, 1994;Mocarelli et al, 1996Mocarelli et al, , 2000, thyroid function (Pluim et al, 1993;Koopman -Esseboom et al, 1994 ), neurological development (Huisman et al, 1995;Koopman -Esseboom et al, 1996;Patandin et al, 1999 ), and immune status . 1.…”

Section: Introductionmentioning

confidence: 99%

Characterization of dioxin exposure in residents of Chapaevsk, Russia

Arslan

Revich

Adibi

et al. 2002

J Expo Sci Environ Epidemiol

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Since 1967, a chemical plant in the town of Chapaevsk ( Samara province, Russia ) has produced large amounts of chlorinated compounds and is suspected to be a major source of local environmental dioxin contamination. Dioxins have been detected in the local air, soil, drinking water, vegetables, and cow's milk. Human exposure to dioxins is suspected as a factor in the deteriorating local public health. In an effort to characterize nonoccupational dioxin exposure among local residents, during the summer of 1998, 24 volunteers were recruited to donate blood and to provide information about their residence, employment, demographics, medical history, and dietary habits. Selected polychlorinated dibenzodioxins, dibenzofurans, and coplanar biphenyls were measured in blood serum samples. The mean concentration of total dioxin World Health Organization toxic equivalents ( WHO -TEQ 98 ) based on polychlorinated dibenzo -paradioxins ( PCDDs ), polychlorinated dibenzofurans ( PCDFs ), and coplanar polychlorinated biphenyls ( PCBs ) was 61.2 ( range 16.4 -168.1 ) pg / g lipid. Subjects living in close proximity to the plant ( less than 5 km ) had significantly higher dioxin levels ( mean WHO -TEQ 98 , 75.7 pg / g lipid ), as compared to subjects living more than 5 km from the plant ( mean WHO -TEQ 98 , 44.1 pg / g lipid ) ( P < 0.04 ). Comparisons of the study results with available published data indicate that average blood dioxin levels were substantially higher in Chapaevsk residents than in nonoccupationally exposed populations of other parts of Russia, Europe, and North America. Chronic exposures of such magnitude may have appreciable adverse effects on public health.

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Change in sex ratio with exposure to dioxin

Cited by 302 publications

References 3 publications

Distribution, Transformation, and Long-Term Accumulation of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans in Different Tissues of Fish and Piscivorous Birds

Distribution, Transformation, and Long-Term Accumulation of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans in Different Tissues of Fish and Piscivorous Birds

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

Characterization of dioxin exposure in residents of Chapaevsk, Russia

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