Objective: To evaluate the effects of orthodontic camouflage treatment (OCT), one-jaw surgery, and two-jaw surgery on the correction of lip line cant (LLC) and to examine factors affecting the correction of LLC in Class III craniofacial asymmetry patients. Materials and Methods: A sample of 30 Class III craniofacial asymmetry patients was divided into OCT (n ¼ 10), one-jaw surgery (n ¼ 10), and two-jaw surgery (n ¼ 10) groups such that the pretreatment LLC was similar in each group. Pretreatment and posttreatment cone-beam computed tomography scans were used to measure dental and skeletal parameters and LLC. Pretreatment and posttreatment measurements were compared within groups and between groups. Pearson's correlation tests and multiple regression analyses were performed to investigate factors affecting the amount and rate of LLC correction. Results: The average LLC correction was 1.008 in the one-jaw surgery group, and in the two-jaw surgery group, it was 1.718. In the OCT group it was À0.048, which differed statistically significantly from the LLC correction in the other two groups. The amount and rate of LLC correction could be explained by settling of skeletal discrepancies or LLC at pretreatment with goodness of fit percentages of approximately 82% and 41%, respectively. Conclusions: Orthognathic surgery resulted in significant correction of LLC in Class III craniofacial asymmetry patients, while OCT did not. (Angle Orthod. 2017;87:239-245)