Change of Optical Properties of Hair Cells During Malignant Tumor Development

Abstract

Abstract. The results of experimental investigations on the differences of wool microstructure and its biophysical properties of healthy mice and mice with malignant tumour are represented in the paper. It is shown that destruction of wool structure as well as biochemical composition change of wool cells is during pathology development. Difference is seen even when tumour is small. We have shown that the general regularity of spectral measurements for mammary and hair cells is conserved at health state and pathology present. Taking into account this, the represented data about wool structure can be used to improve the optical techniques for non--invasive diagnostics of cancer diseases at different stages of pathology. © 2015 Samara State Aerospace University (SSAU).

Medulla loss of scalp hair in breast cancer patients determined by near-infrared microscopy

“…Structural destruction of the hair medulla was also observed in the hair of mice that developed tumors in the mammary gland. 7 Interestingly, HSs from benign fibroadenoma patients demonstrated a typical island-type of pattern in the medulla of all four patients, indicating DML, as shown in Figs. 1(b) and 1(e).…”

“…In this regard, a faster, cheaper, and more convenient imaging method for detecting medulla loss in hair samples is required in practical clinical settings, such as point-of-care technology (POCT). In general, coarser hairs of adults are known to contain either discontinuous or continuous medulla, 5,6 but only a few studies, 4,7 including our prior work, 4 reported any transformation of the medulla structure due to disease. The porous medulla structure was previously known to affect the appearance of hair color due to optical scattering by air in the pores 8,9 or to mechanical properties.…”