Changeable naevi in people at high risk for melanoma

Abbott, Nicola C. D.; Pandeya, Nirmala; Ong, Natalie; McClenahan, Phil; Smithers, B. Mark; Green, Adèle C.; Soyer, H. Peter

doi:10.1111/ajd.12181

Cited by 9 publications

(13 citation statements)

References 19 publications

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“…2), excising all lesions is ineffective, and therefore total body skin photography, digital dermoscopic documentation, and periodic monitoring represent the correct approach. During the follow-up, asymmetrical growth could be a good indicator for the excision of a melanocytic lesion, although naevi can also continue to change in size throughout adulthood, showing both increases and decreases in size [2] (Fig. 3).…”

Section: Melanomamentioning

confidence: 99%

Dermoscopy of Malignant Skin Tumours: What's New?

Russo

Piccolo²,

Lallas³

et al. 2017

Dermatology

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Section: Melanomamentioning

confidence: 99%

Dermoscopy of Malignant Skin Tumours: What's New?

Russo

Piccolo²,

Lallas³

et al. 2017

Dermatology

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“…For example, the lower prevalence in older age groups may be due to the generally lower sun exposure in earlier time periods (cohort effect) rather than an age effect (Bolanca et al, 2008). Almost all longitudinal studies have been undertaken in high-risk groups such as melanoma patients, their relatives, or atypical nevus patients (Abbott et al, 2015;Banky et al, 2005;Halpern et al, 1993), and their findings are unlikely to apply to the population at large. Therefore, we performed a systematic review of longitudinal studies of nevus counts in the general population.…”

Section: To the Editormentioning

confidence: 99%

The Natural History of Common Melanocytic Nevi: A Systematic Review of Longitudinal Studies in the General Population

Plasmeijer

Nguyen

Olsen

et al. 2017

Journal of Investigative Dermatology

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“…In both adults and children, new naevi can develop and existing naevi can regress. 5–7 Melanomas often grow adjacent to, or in some cases, within pre-existing naevi 8 and naevi are the major differential diagnosis of primary melanoma. 9 Therefore, improved understanding of naevus development and recognition of the importance of changes over time is key to understanding melanoma development and will help establish more efficient prevention and early detection models for melanoma.…”

Section: Introductionmentioning

confidence: 99%

‘Mind your Moles’ study: protocol of a prospective cohort study of melanocytic naevi

et al. 2018

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IntroductionHaving many melanocytic naevi or ‘moles’ on the skin is the strongest predictor of melanoma; thus, much can be learnt from investigating naevi in the general population. We aim to improve the understanding of the epidemiology and biology of naevi by conducting a 3-year prospective study of melanocytic naevi in adults.Methods and analysisThis is a population-based cohort study of melanocytic naevi in 200 adults aged 20–69 years recruited via the Australian electoral roll. At baseline, participants will complete a questionnaire on their sun behaviour and health and undergo a clinical examination. Three-dimensional (3D) total-body photography will be used to record the images of skin lesions. Pigmented naevi will be analysed in terms of number, diameter, colour and border irregularity using automated analysis software (excluding scalp, beneath underwear and soles of feet). All naevi ≥5 mm will be recorded using the integrated dermoscopy photographic system. A saliva sample will be obtained at baseline for genomic DNA analysis of pigmentation, naevus and melanoma-associated genes using the Illumina HumanCoreExome platform. The sun behaviour and health follow-up questionnaire, clinical examination and 3D total-body photography will be repeated every 6 months for 3 years. The first 50 participants will also undergo manual counts of naevi ≥2 mm and ≥5 mm at baseline, 6-month and 12-month follow-ups. Microbiopsy and excision of naevi of research interest is planned to commence at the 18-month time point among those who agree to donate samples for detailed histopathological and molecular assessment.Ethics and disseminationThis study was approved by the Metro South Health Human Research Ethics Committee in April 2016 (approval number: HREC/16/QPAH/125). The findings will be disseminated through peer-reviewed and non-peer-reviewed publications and presentations at conferences.

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Changeable naevi in people at high risk for melanoma

Abstract: Naevi can continue to change in size throughout adulthood, showing both increases and decreases in size as well as the appearance of new naevi. This has important clinical implications, in particular for sequential body imaging used for the detection of melanoma.

Cited by 9 publications

References 19 publications

Dermoscopy of Malignant Skin Tumours: What's New?

Dermoscopy of Malignant Skin Tumours: What's New?

The Natural History of Common Melanocytic Nevi: A Systematic Review of Longitudinal Studies in the General Population

‘Mind your Moles’ study: protocol of a prospective cohort study of melanocytic naevi

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