Changes in airway hyperresponsiveness following smoking cessation: Comparisons between Mch and AMP

Piccillo, Giovita; Caponnetto, Pasquale; Barton, Sheila J.; Russo, Cristina; Origlio, Alfio; Bonaccorsi, A.; Maria, Annalisa Di; Oliveri, C.; Polosa, Riccardo

doi:10.1016/j.rmed.2007.09.004

Cited by 46 publications

(48 citation statements)

References 39 publications

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“…As reported by VAN DEN BERGE et al [12], the critical role of inflammatory cells, such as neutrophils, macrophages and lymphocytes, and air trapping in relation to BHR serves as a characterisation tool in the distinction of phenotypes of chronic airway diseases. Prospective studies have shown significant reduction in BHR in asthmatic smokers after quitting; thus smokers should be assisted in quitting [10,11].…”

Section: Discussionmentioning

confidence: 99%

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Dose-dependent association of smoking and bronchial hyperresponsiveness

et al. 2013

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Our aim was to study the association of smoking habits and environmental tobacco smoke (ETS) exposure with bronchial hyperresponsiveness (BHR).A random sample of 292 adults was examined using a structured interview, spirometry, skin prick tests, exhaled nitric oxide fraction (FeNO) and bronchial histamine challenge.A large majority of subjects with BHR were smokers or ex-smokers. Starting to smoke before 20 years of age was significantly associated with BHR, as was current smoking, quantity of smoking and ETS exposure. The severity of BHR increased significantly with increasing pack-years of exposure (p,0.001). Current smokers with decreased lung function were at a particularly high risk of BHR. Impaired forced expiratory volume in 1 s and mean maximal expiratory flow were independent determinants for more severe BHR, regardless of age. In multivariate analysis, smoking remained an independent determinant for BHR after adjustment for impaired lung function and other covariates: o15 pack-years yielded an odds ratio of 3.00 (95% CI 1.33-6.76) for BHR. The association between BHR and FeNO was dependent on smoking habits.The results indicate that smoking is a significant risk factor for BHR, with a dose-dependent pattern, and that the severity of BHR increases with pack-years. The findings strongly suggest assessment of smoking habits in subjects with BHR. @ERSpublications Bronchial hyperresponsiveness is dose-dependently linked to smoking; severity increases with pack-years

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Section: Discussionmentioning

confidence: 99%

“…BHR testing is a common tool in diagnosing asthma, but the effects of smoking have been unclear when interpreting causes of BHR [9]. The association of BHR and smoking has been studied mostly in selected populations [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent association of smoking and bronchial hyperresponsiveness

et al. 2013

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“…The smoking-cessation intervention adopted at our clinical research unit has been described previously [13]. At baseline, sociodemographic factors together with a detailed smoking history (number of cigarettes smoked per day, pack-yrs, previous quit attempts and motivation score) were recorded.…”

Section: Study Design and Proceduresmentioning

confidence: 99%

“…This questionnaire (Appendix 1) evaluates the motivation of a smoker willing to make a quit attempt and consists of 15 items. It classifies motivation to quit according to four possibilities of success: 1) it is not the time to quit (,6), 2) discrete (6-12), 3) good (12)(13)(14)(15)(16), and 4) very good (.16). The GN-SBQ (Appendix 2) consists of 11 items and classifies behavioural dependence according to quartiles: mild (,12), moderate (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), strong (23-33) and very strong (.33).…”

Section: Study Design and Proceduresmentioning

confidence: 99%

Effect of a nicotine-free inhalator as part of a smoking-cessation programme

Caponnetto¹,

Cibella²,

Mancuso³

et al. 2011

Eur Respir J

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Smoking-cessation drugs are inadequate at addressing the behavioural component of tobacco dependence. Nicotine-free inhalators are plastic devices that may provide a coping mechanism for conditioned smoking by replacing some of the rituals associated with smoking gestures. This study assessed the effect of using a nicotine-free inhalator to improve success in a cessation programme.At baseline, 120 smokers attending a smoking-cessation programme were assessed for their sociodemographic factors, smoking history, depression, physical and behavioural dependence, and motivation. Participants were randomly assigned to two groups, nicotine-free inhalator group (PAIPO; Echos Srl, Milan, Italy) versus reference group.For the whole sample, no significant difference was found in quit rates at 24 weeks between the PAIPO group and the reference group. However, the quit rate in the PAIPO group (66.7%) was more than three-fold higher than the reference group (19.2%) for those individuals with high Glover-Nilsson Smoking Behavioural Questionnaire (GN-SBQ) scores at baseline. The results of the logistic model analysis indicate that a high GN-SBQ score is a strong independent predictor for successful quitting at 24 weeks (OR 8.88; 95% CI 2.08-37.94) in the PAIPO group.Nicotine-free inhalators may be beneficial when used in the context of smoking-cessation interventions, particularly for those smokers for whom handling and manipulation of their cigarettes plays an important part in the ritual of smoking.

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“…At CPCT, smoking cessation programs are based on an adaptation from the Clinical Practice Guideline on Smoking Cessation of the US Department of Health and Human Services [5] and have been described previously in detail [15]. Staff at CPCT includes a dedicated team of clinical psychologists, psychiatrists, physicians, and nurses with at least 3-yr experience.…”

Section: Case Reportmentioning

confidence: 99%