Changes in .ALPHA.-adrenergic receptors in rat brain in vitro by preincubation with .ALPHA.-adrenergic ligands.

Hata, Fumiaki; Uchida, Shuji; Ishida, Hideyuki; Yoshida, Hiroshi

doi:10.1254/jjp.30.570

Cited by 11 publications

(1 citation statement)

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“…Brief exposure of human platelets to agonist resulted in increase in acadrenoceptor binding (Cooper, Handin, Young & Alexander, 1978). Pre-incubation of rat brain homogenate with a-adrenergic agonists at 25 IC for 30 min caused increase in [3H]WB-4101 binding (Hata, Uchida, Takeyasu, Ishida & Yoshida, 1980). Pre-treatment with adrenaline caused an increase in the response as well as the cz-adrenoceptor number in rat vas deferens and pre-treatment with ACh caused potentiation of ACh contraction mediated through nicotinic ACh receptor in denervated skeletal muscle (Harborne & Smith, 1979).…”

Section: Discussionmentioning

confidence: 99%

beta‐Adrenoceptor alterations coupled with secretory response in rat parotid tissue.

Hata¹,

Ishida²,

Kagawa³

et al. 1983

The Journal of Physiology

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SUMMARY1. Simultaneous studies on the secretary response of amylase and the neurotransmitter receptors ofrat parotid gland, after brieftreatment with agonists, showed selective alteration in /1-adrenoceptors with specific change in amylase secretion, suggesting a regulatory role of the receptors in the secretary response.2. The fl-adrenergic agonist (± )-isoprenaline (IPR) stimulated amylase secretion from rat parotid tissues much more than did the same concentration ofan a-adrenergic or cholinergic agonist.3. The stimulatory effects of JPR were studied by pre-treating rat parotid tissues with IPR for 10 min and then incubating the tissue in fresh medium for 10 min.Pre-treatment with 10 ,pM-IPR for 10 min resulted in increased amylase secretion during further incubation with IPR and also in a lower EC60 value of amylase secretion for IPR.4. This treatment also resulted in selective changes in the number and affinity of 8. The alteration in fl-adrenoceptors was parallel with a change in amylase secretion after IPR pre-treatment, but not with a change in cyclic AMP content.

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Section: Discussionmentioning

confidence: 99%