Changes in angiotensin-converting enzyme activity and angiotensin I level in asthmatic and healthy children after submaximal physical work

Arvay, G; G, Szathmáry; Reuter, Magda

doi:10.1016/0091-6749(82)90097-5

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…In contrast, our study was well controlled with the application of an identical stimulus to a larger and relatively homogeneous subject group. Our findings are supported by three previous studies using larger groups: (1) of 15 young healthy males, undertaking identical graded bicycle ergometer exercise at a similar intensity to that in our group (Novo et al 1987); (2) of 16 healthy children undergoing graded bicycle ergometry (Arvay et al 1982), and (3) of handgrip exercise amongst 19 subjects (Musumeci et al 1987). …”

Section: Ace Activitysupporting

confidence: 90%

“…However, it has been proposed that ACE becomes rate limiting in situations when levels of substrate Ang I increase. Exercise is associated with a rise in levels of plasma renin substrate (Metsarinne 1988), which is thought to be consumed, on account of the associated rise in renin activity (Fyhrquist et al 1983;Kosunen and Pakarinen 1976;Milledge and Catley 1982), to yield a rise in Ang I levels (Arvay et al 1982). It is also known that when levels of Ang I are artificially elevated through infusion, Ang II levels may become ACE genotypedependent (Brown et al 1998;Ueda et al 1995).…”

Section: Ang II Responsementioning

confidence: 98%

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The serum angiotensin-converting enzyme and angiotensin II response to altered posture and acute exercise, and the influence of ACE genotype

Woods

Sanders

Jones

et al. 2004

European Journal of Applied Physiology

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The deletion (D) rather than insertion (I) allele of the angiotensin-converting enzyme (ACE) gene is associated with greater ACE activity. We examined: (1) the influence of posture change (recumbent to seated) and acute exercise on serum ACE and angiotensin II (Ang II) activity; (2) the relationship between ACE and Ang II levels; and (3) the influence of ACE genotype on changes in ACE and Ang II levels with posture and exercise. Recreationally active young male Caucasians (10 each of II, ID and DD genotypes) rested for 35 min supine then 15 min upright, took 20 min bicycle ergometric exercise at 70% maximum oxygen uptake, then rested for 40 min. Samples were taken throughout for ACE activity and Ang II levels. Supine ACE levels were dependent upon ACE genotype [24.8 (5.7), 26.9 (4.5), 45.5 (6.4) nmol His-Leu ml(-1) min(-1); II, ID, DD, respectively; P<0.00005] and thereafter. ACE activity rose with assumption of a seated posture [from 32.4 (10.9) nmol His-Leu ml(-1) min(-1) to 35.0 (11.5) nmol His-Leu ml(-1) min(-1), P<0.00001], the absolute rise being independent of genotype [3.22 (1.92), 1.6 (1.6), 2.4 (2.3) nmol His-Leu ml(-1) min(-1); II, ID, DD; P=0.22], unlike percentage change [12.8 (6.8), 5.6 (5.5), 5.3 (5.0)%; II, ID, DD; P<0.01, and P=0.004 for II vs presence of the D allele]. A further genotype-independent rise occurred with exercise [+2.9 (3.7) units, P<0.0003]. An associated rise in Ang II levels [30.3 (15.9), or 2587.9 (489.76)%, P<0.00001] was independent of ACE genotype or activity. Upright posture increases ACE activity, and this may be influenced by ACE genotype. ACE activity and Ang II levels rise independently with exercise in a non-genotype-dependent fashion.

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Section: Ace Activitysupporting

confidence: 90%

Section: Ang II Responsementioning

confidence: 98%

The serum angiotensin-converting enzyme and angiotensin II response to altered posture and acute exercise, and the influence of ACE genotype

Woods

Sanders

Jones

et al. 2004

European Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

“…51 It has also been low in two studies of patients with asthma, 52 although one report found normal activity. 53…”

Section: Decreased Ace Activitymentioning

confidence: 99%

Angiotensin-Converting Enzyme Activity in Acute Illness

Smallridge

1985

Semin Respir Crit Care Med

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“…It is possible that subject age (children vs adults) and the particular exercise parameters used in the current study and that by Fyhrquist et al (1983) [non-incremental and thus of sustained lower intensity than Lenz et al (1998) and Arvay et al (1982)] can explain the differences between studies. Thus, it is possible that higher intensity exercise may elicit an acute response of circulating ACE activity in adults.…”

Section: Discussionmentioning

confidence: 62%

The acute effects of exercise and glucose ingestion on circulating angiotensin-converting enzyme in humans

et al. 2004

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Angiotensin-converting enzyme (ACE) activity has been suggested as a determinant of some exercise phenotypes via some studies that have associated the ACE gene with exercise performance, although several studies provide conflicting evidence regarding the influence of the ACE gene. The relationships between ACE phenotype (ACE activity) and various exercise parameters should also be examined. An early step in this process is to determine whether common environmental stimuli such as exercise and diet have acute effects on ACE activity. In this study, the acute effects of aerobic exercise, resistance exercise and glucose ingestion on circulating ACE activity were examined. On three separate occasions, 20 healthy adult volunteers (9 female and 11 male) performed 20 min of submaximal cycle exercise at 70-80% of maximal heart rate, four sets of ten repetitions of unilateral leg extension resistance exercise at ten-repetition maximum load, or ingested 1 g kg(-1) glucose. Circulating ACE activity was assessed for 1 h after each intervention using a modified fluorometric method. Pre-intervention ACE activity remained remarkably stable across test days (difference < or =1.8%). Furthermore, there was no significant change in circulating ACE activity following any of the interventions (difference from pre-intervention values < or =6.8% when unadjusted for plasma volume changes, < or =4.5% when adjusted for plasma volume changes). These results suggest that acute exercise and glucose ingestion interventions as used here do not affect circulating ACE activity. These findings are an early step in illuminating the relationships between ACE activity and various exercise parameters.

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Changes in angiotensin-converting enzyme activity and angiotensin I level in asthmatic and healthy children after submaximal physical work

Cited by 5 publications

References 13 publications

The serum angiotensin-converting enzyme and angiotensin II response to altered posture and acute exercise, and the influence of ACE genotype

The serum angiotensin-converting enzyme and angiotensin II response to altered posture and acute exercise, and the influence of ACE genotype

Angiotensin-Converting Enzyme Activity in Acute Illness

The acute effects of exercise and glucose ingestion on circulating angiotensin-converting enzyme in humans

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