Changes in Antisecretory Factor in Human Milk During the Postpartum and Length of Gestation

Gustafsson, Anna; Johansson, Ewa; Henckel, Ewa; Lange, Stefan; Bohlin, Kajsa

doi:10.1177/08903344211021306

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…Furthermore, it has been demonstrated that HM composition differed between people who give birth prematurely and those with full-term deliveries [7][8][9]. Specific HM components, such as insulin [10], lactose, fat, and the total energy content of milk, were not affected by gestational age.…”

Section: Introductionmentioning

confidence: 99%

Human Milk Microbiota Profile Affected by Prematurity in Argentinian Lactating Women

et al. 2023

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To study (16S rRNA-sequencing) the impact of gestational and corrected ages on the microbiota profile of human milk (HM) of mothers that delivered full-term and pre-term children, HM samples were obtained and classified according to the gestational age as group T (full-term births ≥37 weeks), and group P (pre-term births <37 weeks). Group P was longitudinally followed, and the samples were collected at the full-term corrected gestational age: when the chronological age plus the gestational age were ≥37 weeks (PT group). The HM microbiota composition differed depending on the gestational age (T vs. P). Group T had lower levels of Staphylococcus and higher levels of Rothia and Streptococcus, as compared to group P. The alpha Simpson diversity value was higher in group T than in P, whereas no differences were found between groups T and PT, suggesting a microbial evolution of the composition of group P towards group T over chronological age. Full-term delivery was associated with a greater diversity of microbes in HM. The microbial composition of pre-term HM, at the corrected age, did not show significant differences, as compared to the samples obtained from the full-term group, suggesting that it would be appropriate to consider the corrected age in terms of the composition and the diversity of the milk in future studies.

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Section: Introductionmentioning

confidence: 99%

Human Milk Microbiota Profile Affected by Prematurity in Argentinian Lactating Women

et al. 2023

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Antisecretory factor in breastmilk is associated with reduced incidence of sepsis in preterm infants

Gustafsson,

Johansson,

Henckel

et al. 2023

Pediatr Res

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Background Antisecretory Factor (AF) is a protein present in breastmilk that regulates inflammatory processes. We aimed to investigate the level of AF in mothers’ own milk (MOM) in relation to sepsis and other neonatal morbidities in preterm infants. Methods Samples of breastmilk and infant plasma were collected at 1, 4, and 12 weeks after birth from 38 mothers and their 49 infants born before 30 weeks gestation. AF-compleasome in MOM was determined by a sandwich enzyme-linked immunosorbent assay (ELISA) and inflammatory markers in infant plasma by a panel of 92 inflammatory proteins. Neonatal treatments and outcomes were recorded. Results The level of AF in MOM week 1 was lower for infants with later sepsis compared to no sepsis (p = 0.005). Corrected for nutritional intake of MOM, higher levels of AF decreased the risk for sepsis, OR 0.24. AF in MOM week 1 was negatively correlated to inflammatory proteins in infant plasma week 4, markedly IL-8, which was also associated with infant sepsis. Overall, higher AF levels in MOM was associated with fewer major morbidities of prematurity. Conclusion Mother’s milk containing high levels of antisecretory factor is associated with reduced risk for sepsis and inflammation in preterm infants. Impact High level of antisecretory factor (AF) in mothers’ own milk is associated with less risk for later sepsis in preterm infants. Receiving mothers’ milk with low AF levels during the first week after birth is correlated with more inflammatory proteins in infant’s plasma 2–4 weeks later. Human breastmilk has anti-inflammatory properties, and antisecretory factor in mothers’ own milk is a component of potential importance for infants born preterm. The findings suggest that food supplementation with AF to mothers of preterm infants to increase AF-levels in breastmilk may be a means to decrease the risk of inflammatory morbidities of prematurity.

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Changes in Antisecretory Factor in Human Milk During the Postpartum and Length of Gestation

Cited by 2 publications

References 27 publications

Human Milk Microbiota Profile Affected by Prematurity in Argentinian Lactating Women

Human Milk Microbiota Profile Affected by Prematurity in Argentinian Lactating Women

Antisecretory factor in breastmilk is associated with reduced incidence of sepsis in preterm infants

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