Changes in appetite, taste, smell, and food aversion in post-bariatric patients and their relations with surgery time, weight loss and regain

Lopes, Karynne Grutter; Santos, Gabriel Pires Dos; Romagna, Eline Coan; Mattos, Diogo M. F.; Braga, Tassia Gomide; Cunha, Carolina B. da; Maranhão, Priscila Alves; Kraemer‐Aguiar, Luiz Guilherme

doi:10.1007/s40519-021-01304-3

Cited by 9 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One mechanism that might explain altered food preferences and food cravings following RYGB surgery is changes in taste function, as documented here in the brainstem. Some human studies [ 16 , 54 , 55 , 56 , 57 ], as well as our animal research, have confirmed such effects [ 34 ], whereas other findings are more equivocal [ 40 , 58 ]. However, it is possible that changes in food reward, rather than taste sensations, may explain the beneficial outcomes of RYGB surgery [ 59 ].…”

Section: Discussionmentioning

confidence: 72%

The Neural Code for Taste in the Nucleus of the Solitary Tract of Rats with Obesity Following Roux-En-Y Gastric Bypass Surgery

et al. 2022

View full text Add to dashboard Cite

Previous work has shown that taste responses in the nucleus tractus solitarius (NTS; the first central relay for gustation) are blunted in rats with diet-induced obesity (DIO). Here, we studied whether these effects could be reversed by Roux-en-Y gastric bypass (RYGB) surgery, an effective treatment for obesity. Rats were fed a high energy diet (60% kcal fat; HED) both before and after undergoing RYGB. Electrophysiological responses from NTS cells in unrestrained rats were recorded as they licked tastants from a lick spout. Sweet, salty, and umami tastes, as well as their naturalistic counterparts, were presented. Results were compared with those of lean rats from a previous study. As with DIO rats, NTS cells in RYGB rats were more narrowly tuned, showed weaker responses, and less lick coherence than those in lean rats. Both DIO and RYGB rats licked at a slower rate than lean rats and paused more often during a lick bout. However, unlike DIO rats, the proportion of taste cells in RYGB rats was similar to that in lean rats. Our data show that, despite being maintained on a HED after surgery, RYGB can induce a partial recovery of the deficits seen in the NTS of DIO rats.

show abstract

Section: Discussionmentioning

confidence: 72%

The Neural Code for Taste in the Nucleus of the Solitary Tract of Rats with Obesity Following Roux-En-Y Gastric Bypass Surgery

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Experiencing changes in smell was reported by a minority of respondents in each country. Changes in taste and smell perceptions are probably related to adipose–gut–brain-axis modifications which occur following BS and may influence food preferences [ 42 , 43 ]. However, the extent of sensory changes presumably varies between different patients and bariatric procedures.…”

Section: Discussionmentioning

confidence: 99%

“…A previous cross-sectional study among 103 Roux-en-Y gastric bypass (RYGB) patients with a median follow-up of 19 months post-surgery, which used similar tools to assess such outcomes, revealed higher postoperative sensory changes in appetite, taste, and smell [ 29 ]. Nevertheless, another cross-sectional study, which included 126 patients who underwent RYGB or sleeve gastrectomy (SG) with a mean of 5.0 ± 4.0 years since surgery and used similar tools to assess such outcomes, revealed similar trends [ 42 ]. Collectively, future studies should further investigate changes in appetite, taste, and smell following OAGB, preferably using validated and objective methodologies [ 44 ], as these may significantly impact the dietary patterns and nutritional outcomes of patients.…”

Section: Discussionmentioning

confidence: 99%

“…The major strength of this study includes the use of acceptable tools to assess nutrition and lifestyle outcomes. Moreover, the inclusion of patients with three time intervals since the surgery is one of its strengths, as sensory changes and adherence to clinical recommendations could gradually decrease over time [ 18 , 37 , 42 ]. However, there are some limitations to be mentioned.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nutritional and Lifestyle Behaviors Reported Following One Anastomosis Gastric Bypass Based on a Multicenter Study

Sherf-Dagan

Biton

Ribeiro³

et al. 2023

Nutrients

View full text Add to dashboard Cite

This study aimed to describe nutritional and lifestyle parameters following one-anastomosis gastric bypass (OAGB). A multicenter study among OAGB patients across Israel (n = 277) and Portugal (n = 111) was performed. Patients were approached according to the time elapsed since surgery. An online survey with information regarding demographics, anthropometrics, and nutritional and lifestyle aspects was administered in both countries simultaneously. Respondents from Israel (pre-surgery age of 41.6 ± 11.0 years, 75.8% females) and Portugal (pre-surgery age of 45.6 ± 12.3 years, 79.3% females) reported changes in their appetite (≤94.0% and ≤94.6%), changes in their taste (≤51.0 and ≤51.4%), and intolerance to specific foods (i.e., red meat, pasta, bread, and rice). Bariatric surgery-related eating recommendations were generally followed well, but a trend toward lower adherence was evident in groups with longer time elapsed since surgery in both countries. Most respondents from Israel and Portugal reported participation in follow-up meetings with a surgeon (≤94.0% and 100%) and a dietitian (≤92.6% and ≤100%), while far fewer reported participation in any follow-up meeting with a psychologist/social worker (≤37.9% and ≤56.1%). Patients following OAGB might experience changes in appetite, taste, and intolerance to specific foods. Adherence to bariatric surgery-related eating recommendations is not always satisfying, especially in the longer term post-surgery.

show abstract

“…Of note, we found no significant associations between changes in fasting homeostatic or hedonic appetite and changes in BMI. Lopes et al showed that after gastric bypass, the rate of weight regain was higher in those with lesser appetite changes [ 35 ]. The current literature is limited in exploring the association between weight loss and weight regain after SG in youth, and this association needs further evaluation.…”

Section: Discussionmentioning

confidence: 99%

One-Year Self-Reported Appetite Is Similar in Adolescents with Obesity Who Do or Do Not Undergo Sleeve Gastrectomy

et al. 2022

View full text Add to dashboard Cite

Background: With the growing prevalence of severe obesity in adolescents, sleeve gastrectomy (SG), a type of metabolic bariatric surgery (MBS), is increasingly being performed at a younger age. Data regarding changes in homeostatic and hedonic appetite following SG are conflicting in adults, with some studies showing no change and others showing a decrease in appetite. Data evaluating the effect of SG on appetite during adolescence, when appetite is more plastic, are currently lacking. Objective: To evaluate appetite changes one year after SG in adolescents with obesity vs. in non-surgical controls (NS). Methods: Thirty-nine subjects 13–21 years old with severe obesity were followed for a year; 19 underwent SG, and 20 were followed without surgery. Subjects had fasting blood tests for appetite-regulating hormones and completed a visual analog scale for appetite assessment (VAS). Results: The SG group had a decrease in body mass index (BMI) at one-year (baseline: 48.2 ± 1.7 kg/m2; one-year follow-up: 42.6 ± 1.0 kg/m2 (p ≤ 0.0001)). No within- or between-group differences were noted in the one-year change in appetite in the SG and NS groups. After SG, fasting ghrelin decreased (p ≤ 0.0001); however, no changes were noted in peptide YY (PYY) levels. Changes in one homeostatic appetite measure following SG were inversely associated with changes in fasting PYY (r = −0.583, p = 0.011). Appetite changes were not associated with weight loss or final BMI. Conclusions: There were no changes in appetite measures one-year after SG from pre-surgery levels in adolescents with obesity, and appetite changes were not associated with changes in BMI. It is important to evaluate the impact of long-term appetite changes, if any, on weight loss after SG.

show abstract

Changes in appetite, taste, smell, and food aversion in post-bariatric patients and their relations with surgery time, weight loss and regain

Cited by 9 publications

References 30 publications

The Neural Code for Taste in the Nucleus of the Solitary Tract of Rats with Obesity Following Roux-En-Y Gastric Bypass Surgery

The Neural Code for Taste in the Nucleus of the Solitary Tract of Rats with Obesity Following Roux-En-Y Gastric Bypass Surgery

Nutritional and Lifestyle Behaviors Reported Following One Anastomosis Gastric Bypass Based on a Multicenter Study

One-Year Self-Reported Appetite Is Similar in Adolescents with Obesity Who Do or Do Not Undergo Sleeve Gastrectomy

Contact Info

Product

Resources

About