Changes in arterial blood pressure after single oral administration of cuttlefish (Sepia officinalis) muscle derived peptides in spontaneously hypertensive rats

Balti, Rafik; Bougatef, Ali; Guillochon, Didier; Dhulster, Pascal; Nedjar‐Arroume, Naïma

doi:10.1016/j.jff.2012.03.007

Cited by 22 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ACE inhibition is the main mechanism by which peptides can modulate RAS function and exert antihypertensive effects. A number of in vivo studies performed in animals and/or humans have demonstrated that various food-derived peptides could significantly reduce blood pressure through ACE inhibition upon either intravenous or oral administration [ 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 ]. Milk protein derived peptides are known for their antihypertensive activity.…”

Section: Antihypertensive Peptides From Food Proteins—mechanisms Omentioning

confidence: 99%

Molecular Targets of Antihypertensive Peptides: Understanding the Mechanisms of Action Based on the Pathophysiology of Hypertension

Majumder

2014

IJMS

145

105

View full text Add to dashboard Cite

There is growing interest in using functional foods or nutraceuticals for the prevention and treatment of hypertension or high blood pressure. Although numerous preventive and therapeutic pharmacological interventions are available on the market, unfortunately, many patients still suffer from poorly controlled hypertension. Furthermore, most pharmacological drugs, such as inhibitors of angiotensin-I converting enzyme (ACE), are often associated with significant adverse effects. Many bioactive food compounds have been characterized over the past decades that may contribute to the management of hypertension; for example, bioactive peptides derived from various food proteins with antihypertensive properties have gained a great deal of attention. Some of these peptides have exhibited potent in vivo antihypertensive activity in both animal models and human clinical trials. This review provides an overview about the complex pathophysiology of hypertension and demonstrates the potential roles of food derived bioactive peptides as viable interventions targeting specific pathways involved in this disease process. This review offers a comprehensive guide for understanding and utilizing the molecular mechanisms of antihypertensive actions of food protein derived peptides.

show abstract

Section: Antihypertensive Peptides From Food Proteins—mechanisms Omentioning

confidence: 99%

Molecular Targets of Antihypertensive Peptides: Understanding the Mechanisms of Action Based on the Pathophysiology of Hypertension

Majumder

2014

IJMS

145

105

View full text Add to dashboard Cite

show abstract

“…The kinetic constants of competitive and non-competitive ACE inhibitory peptides indicate a decrease in V max as the concentration of inhibitor increases . Peptides isolated from collagen hydrolysates exhibit competitive ACE inhibitory activity . Research by Memarpoor-Yazdi et al showed that egg white lysozyme-derived peptide inhibited ACE activity in a non-competitive manner, indicating an interaction with the enzyme protein outside the active site.…”

Section: Discussionmentioning

confidence: 99%

“…37 Peptides isolated from collagen hydrolysates exhibit competitive ACE inhibitory activity. 38 Research by Memarpoor-Yazdi et al 39 showed that egg white lysozyme-derived peptide inhibited ACE activity in a non-competitive manner, indicating an interaction with the enzyme protein outside the active site. ACE inhibitory peptide (Val-Glu-Cys-Tyr-Gly-Pro-Asn-Arg-Pro-Gln-Phe) isolated from the pepsin hydrolysate of algae protein waste from Chlorella vulgaris was found to have an IC 50 value of 29.6 μM against ACE as a non-competitive inhibitor.…”

Section: ■ Discussionmentioning

confidence: 99%

Mechanism Analysis of a Novel Angiotensin-I-Converting Enzyme Inhibitory Peptide from Isochrysis zhanjiangensis Microalgae for Suppressing Vascular Injury in Human Umbilical Vein Endothelial Cells

Chen

Tan

et al. 2020

J. Agric. Food Chem.

View full text Add to dashboard Cite

Microalgae are primary producers with multiple nutrients in aquatic environments and mostly have applications in biological feed and fuel industry. There are few studies assessing the angiotensin-I-converting enzyme (ACE) inhibition potential of Isochrysis zhanjiangensis, other than its antioxidant potential. In this study, we evaluated a peptide from I. zhanjiangensis (PIZ, FEIHCC) and its vascular endothelial factors and mechanism in human umbilical vein endothelial cells (HUVEC). The results reveal that PIZ (IC 50 = 61.38 μM) acts against ACE in a non-competitive binding mode. In addition, PIZ inhibits angiotensin II (Ang II)-induced vascular factor secretion and expression by blocking inflammation and apoptosis through nuclear factor κB (NF-κB), nuclear erythroid 2-related factor 2 (Nrf2), mitogen-activated protein kinases (MAPKs), and the serine/threonine kinase (Akt) signal pathways. This study reveals that PIZ has potential to be developed as a therapeutic agent for hypertension and provides a new method of high-value utilization of I. zhanjiangensis.

show abstract

Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats

Girgih

Alashi

et al. 2013

Eur J Nutr

View full text Add to dashboard Cite

show abstract

Changes in arterial blood pressure after single oral administration of cuttlefish (Sepia officinalis) muscle derived peptides in spontaneously hypertensive rats

Cited by 22 publications

References 41 publications

Molecular Targets of Antihypertensive Peptides: Understanding the Mechanisms of Action Based on the Pathophysiology of Hypertension

Molecular Targets of Antihypertensive Peptides: Understanding the Mechanisms of Action Based on the Pathophysiology of Hypertension

Mechanism Analysis of a Novel Angiotensin-I-Converting Enzyme Inhibitory Peptide from Isochrysis zhanjiangensis Microalgae for Suppressing Vascular Injury in Human Umbilical Vein Endothelial Cells

Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats

Contact Info

Product

Resources

About