Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats

Abstract

The results suggest that HMH with strong hypotensive effects in SHRs could be used as a therapeutic agent for both the prevention and treatment of hypertension.

Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides

“…For example, enzymatic food protein hydrolysates and peptides with antihypertensive activities have been widely demonstrated García-Tejedor et al, 2014;He, Alashi, Malomo, et al, 2013;He, Malomo, Alashi, et al, 2013;He, Malomo, Girgih, Ju, & Aluko, 2013;Huang, Sun, He, Dong, & Li, 2011;Li et al, 2011;Majumder et al, 2013;Yamada et al, 2013). Some of the reports have also shown that the blood pressure-lowering effect of the food protein hydrolysates and peptides is related to direct in vivo reduction in plasma ACE and renin activities (García-Tejedor et al, 2014;Girgih, Alashi, He, Malomo, & Aluko, 2014;Huang et al, 2011). A recent report has shown the uptake of a casein-derived peptide (HLPLP) from the gastrointestinal tract into rat blood, which confirms that some of these food protein-derived peptides could be bioavailable .…”

Processing, Nutrition, and Functionality of Hempseed Protein: A Review

“…The specific health‐promoting activities include angiotensin I‐converting enzyme (ACE) inhibition, renin inhibition, acetylcholinesterase (AChE) inhibition, metal‐binding capacity, antioxidant activity, hypocholesterolemic effect, and serum glucose regulation. The bioactivity is elicited through the hydrolysis with gastrointestinal enzymes (pepsin, pancreatin, and trypsin) (Aiello et al., ; Girgih et al., ,b; Girgih, Alashi, He, Malomo, & Aluko, ; Girgih, He, & Aluko, ; Girgih, Udenigwe, & Akuko, , ; Girgih, Udenigwe, Li, Adebiyi, & Aluko, ; Zanoni, Aiello, Arnoldi, & Lammi, ) or exogenous proteases such as alcalase, papain, flavourzyme, neutrase, and thermolysin (Hadnađev et al., ; Lu et al., ; Malomo & Akuko, ; Malomo, Onuh, Girgih, & Aluko, ; Tang, Wang, & Yang, ; Wang, Tang, Chen, & Yang, ). Peptides with ACE inhibitory activity have also been produced from hemp protein with acid hydrolysis (Orio et al., ).…”

“…Girgih et al, 2011b r Plasma ACE activity was remarkably suppressed in hempseed meal protein hydrolysate (HMH)-fed rats compared to control rats. Girgih et al, 2014a r HT (bacterial) produced the highest ACE-inhibitory activity of alkali-and acid-extracted HPI among all microbial and plant proteases (AFP, HT, protease G, actinidin, and zingibain). Teh et al, 2016 r Four peptides (GVLY, IEE, LGV, and RVR) were identified from HPH by extensive chemical hydrolysis (6 M HCl).…”

Inhibition of the in vitro activities of α‐amylase, α‐glucosidase and pancreatic lipase by yellow field pea (Pisum sativum L.) protein hydrolysates

“…Several reports in literature have confirmed the role of bioactive peptides as inhibitors of various metabolic enzymes and with potential use as therapeutic agents against specific diseases. For example food protein‐derived peptides act as antihypertensive agents by inhibiting angiotensin‐converting enzyme (Sanchez‐Rivera et al ., ; Ciau‐Solis et al ., ) and renin activities (He et al ., ; Girgih et al ., ). Peptides also possess antioxidative properties (Jara et al ., ; Ma et al ., ), whereas some sequences act as anti‐cancer agents by inhibiting excessive cell proliferation (Chi et al ., ; Vasquez‐Villanueva et al ., ).…”