Changes in arterial norepinephrine concentration following intravenous administration in dogs with lung edema.

Imamura, Takeaki; Yasuda, Akio; Amaha, Keisuke

doi:10.1620/tjem.156.271

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…This study had several limitations. The half-life of NE of approximately 2 minutes was obtained from data in human patients to choose 10 minutes for washout and equilibration times (Imamura et al 1988;Beloeil et al 2005). NE is an immediate precursor of epinephrine and the primary method of elimination is by reuptake into the adrenergic nerve endings; therefore, the influence of NE in the sympathetic system may be longer than indicated by the pharmacokinetic profile.…”

Section: Discussionmentioning

confidence: 99%

“…Cardiopulmonary variables were recorded before starting each NE treatment, times baseline and 1, 2, 3 and 10 minutes after starting each infusion. A 10 minute equilibration during NE infusion and 10 minute washout period between treatments were chosen to ensure steady state and clearance of the drug between treatments based on NE half-life values of 2 minutes described in other species (Imamura et al 1988;Beloeil et al 2005). The last cardiopulmonary values were recorded (recovery) 10 minutes after the end of the last NE infusion and right before isoflurane was discontinued.…”

Section: Experimental Designmentioning

confidence: 99%

See 1 more Smart Citation

Cardiovascular effects of increasing dosages of norepinephrine in healthy isoflurane-anesthetized New Zealand White rabbits

Uccello

Sánchez

Valverde

et al. 2020

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

Cardiovascular effects of increasing dosages of norepinephrine in healthy isoflurane-anesthetized New Zealand White rabbits

Uccello

Sánchez

Valverde

et al. 2020

Veterinary Anaesthesia and Analgesia

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Potential of iodine-123 metaiodobenzylguanidine single-photon emission tomography to detect abnormal functional status of the pulmonary neuroadrenergic system in irradiated lung

Suga

Kume

Shimizu

et al. 1999

European Journal of Nuclear Medicine and Molecular Imaging

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The potential of iodine-123 metaiodobenzylguanidine (MIBG) to detect functional abnormalities of the pulmonary neuroadrenergic system (PNS) in irradiated lung areas (ILAS) was preliminarily explored using single-photon emission tomography (SPET). The subjects included five healthy subjects and a total of 31 patients with peripheral-type lung cancer treated by radiation; 15 patients (group A) had received a dose of less than 36 Gy (mean +/- SD: 28.2 +/-6.2 Gy), and 16 patients (group B) had received a higher dose (mean +/- SD: 51.2 +/- 3.5 Gy) at the time of examination. MIBG SPET scans acquired 15 min and 3 h after injection were used to measure the MIBG uptake ratio (count ratio of the ILA to the contralateral non-ILA) and the clearance rate [percentage of (early counts - delayed counts)/early counts] from the ILAs without noticeable abnormal opacities on chest computed tomography scan. Lung perfusion changes were also assessed by technetium-99m macroaggregated albumin SPET. By contrast to the homogeneous MIBG uptake in the lungs of the healthy subjects, MIBG uptake was folcally decreased in correspondence with the ILAs in all patients, including 11 patients (73.3%) of group A with relatively preserved lung perfusion. The reduction MIBG uptake was significant (P<0.0001), and the MIBG clearance rate from the ILAs was also significantly faster than the clearance rates from the normal lungs and contralateral non-ILAs (both P<0.01). Group B patients showed significantly lower MIBG uptake and faster clearance from the ILAs than group A patients (P<0. 001 and P<0.05, respectively), although there was no significant difference in the clearance from the non-ILAs. Overall, MIBG uptake/clearance from the ILAs correlated significantly with the radiation dose in the 31 patients (r = -0.656; P<0.0001 and r = 0. 387; P<0.05, respectively). Perfusion changes were inversely correlated with the clearance from the ILAs (r = -0.432, P<0.05), but did not correlate with MIBG uptake. These preliminary results suggest that MIBG may have the potential to be a marker of abnormal functional status of the PNS produced by irradiation and may facilitate investigation of irradiation lung injury independently of morphological or lung perfusion changes.

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Changes in arterial norepinephrine concentration following intravenous administration in dogs with lung edema.

Cited by 2 publications

References 13 publications

Cardiovascular effects of increasing dosages of norepinephrine in healthy isoflurane-anesthetized New Zealand White rabbits

Cardiovascular effects of increasing dosages of norepinephrine in healthy isoflurane-anesthetized New Zealand White rabbits

Potential of iodine-123 metaiodobenzylguanidine single-photon emission tomography to detect abnormal functional status of the pulmonary neuroadrenergic system in irradiated lung

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