Changes in atrial electrophysiological and structural substrate and their relationship to histology in a long‐term chronic canine atrial fibrillation model

Yamashita, Kennosuke; Silvernagel, Josh; Kwan, Eugene; Kamali, Roya; Ghafoori, Elyar; MacLeod, Robert S.; Dosdall, Derek J.; Ranjan, Ravi

doi:10.1111/pace.13730

Cited by 12 publications

(7 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To identify the most distinctive and functionally important taxa between PAF and psAF, correlation analyses of taxa and atrial diameter were performed. An enlarged atrium, including left atrial anterior-posterior diameter (LAAPD), left atrial superior-inferior diameter (LASID), left atrial left-right diameter (LALRD), right atrial left-right diameter (RALRD), and right atrial superior-inferior diameter (RASID), is the marker of irreversible atrial remodeling (28)(29)(30)(31). Overall, one family (Holosporaceae), two genera (Methylovulum and Holospora), and five species including Methylovulum miyakonense, Bacillus sp.…”

Section: Resultsmentioning

confidence: 99%

“…Alterations in GM would lead to subsequent changes in choline production. Left atrial enlargement, reflected by atrial diameter, is the marker of irreversible atrial remodeling (28)(29)(30)(31). Also, previous studies have shown that left atrial diameter is an independent risk factor for the development of AF and the long-term outcomes of ablation (39,40).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis

Zuo

Yin

et al. 2020

mSphere

View full text Add to dashboard Cite

Dysbiotic gut microbiota (GM) and disordered metabolic patterns are known to be involved in the clinical expression of atrial fibrillation (AF). However, little evidence has been reported in characterizing the specific changes in fecal microbiota in paroxysmal AF (PAF) and persistent AF (psAF). To provide a comprehensive understanding of GM dysbiosis in AF types, we assessed the GM signatures of 30 PAF patients, 20 psAF patients, and 50 non-AF controls based on metagenomic and metabolomic analyses. Compared with control subjects, similar changes of GM were identified in PAF and psAF patients, with elevated microbial diversity and similar alteration in the microbiota composition. PAF and psAF patients shared the majority of differential taxa compared with non-AF controls. Moreover, the similarity was also illuminated in microbial function and associated metabolic alterations. Additionally, minor disparity was observed in PAF compared with psAF. Several distinctive taxa between PAF and psAF were correlated with certain metabolites and atrial diameter, which might play a role in the pathogenesis of atrial remodeling. Our findings characterized the presence of many common features in GM shared by PAF and psAF, which occurred at the self-terminating PAF. Preventative and therapeutic measures targeting GM for early intervention to postpone the progression of AF are highly warranted. IMPORTANCE Atrial fibrillation has been identified to be associated with disordered gut microbiota. Notably, atrial fibrillation is a progressive disease and could be categorized as paroxysmal and persistent based on the duration of the episodes. The persistent atrial fibrillation patients are accompanied by higher risk of stroke and lower success rate of rhythm control. However, the microbial signatures of different categories of atrial fibrillation patients remain unknown. We sought to determine whether disordered gut microbiota occurs in the self-terminating PAF or intestinal flora develops dynamically during atrial fibrillation progression. We found that different types of atrial fibrillation show a limited degree of gut microbiota shift. Gut microbiota dysbiosis has already occurred in mild stages of atrial fibrillation, which might act as an early modulator of disease, and therefore may be regarded as a potential target to postpone atrial fibrillation progression.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis

Zuo

Yin

et al. 2020

mSphere

View full text Add to dashboard Cite

show abstract

“…AF has been identified as a progressive disease, with an “AF begets AF” effect that fosters disease progression (7). Each episode of AF induces atrial electrical and structural remodeling, complex self-sustaining electrical activity, and even irreversible atrial fibrosis, which together contribute to the maintenance of AF (8, 9). Based on an electrocardiogram and AF duration, persistent AF (psAF) is divided into two clinically defined groups: (i) psAF of <12 months (Pers<12m) refers to a duration of AF disease for longer than 7 days but less than 1 year, and (ii) psAF of >12 months (Pers>12m) refers to a duration of AF of greater than 1 year (10).…”

Section: Introductionmentioning

confidence: 99%

Duration of Persistent Atrial Fibrillation Is Associated with Alterations in Human Gut Microbiota and Metabolic Phenotypes

Zuo

Wang

et al. 2019

mSystems

View full text Add to dashboard Cite

Atrial fibrillation was associated with a disordered gut microbiota in previous research. However, the gut microbiota signature of patients at different stages of atrial fibrillation remains largely unknown. We sought to determine whether the shift in the gut microbiota and metabolic profiles occurs early and remains stable or develops gradually during atrial fibrillation. We found that patients with persistent atrial fibrillation of <12 months and persistent atrial fibrillation of >12 months shared most of the common features of gut microbiota dysbiosis. However, some distinctive and progressive alterations in the gut microbiota and metabolic structure, which may contribute to the progression of atrial fibrillation, were identified. The present study provides a comprehensive description of the dysbiotic gut microbiota and metabolic profiles in patients of short and long persistent atrial fibrillation, and our findings may help identify therapeutic strategies targeting the gut microbiota to treat atrial fibrillation at an early stage.

show abstract

“…[1][2][3] Areas with reduced bipolar voltage are defined as low-voltage areas (LVAs), and have been reported to correspond to fibrotic regions. 4,5 After pulmonary vein isolation (PVI), LA LVAs have been reported as predictors of recurrent AF. [1][2][3]6 Patients who underwent LVA ablation following PVI demonstrated better long-term outcomes than controls undergoing PVI alone in limited nonrandomized studies.…”

Section: Introductionmentioning

confidence: 99%

“…Left atrial (LA) voltage mapping is performed to identify atrial arrhythmogenic substrates during atrial fibrillation (AF) ablation 1–3 . Areas with reduced bipolar voltage are defined as low‐voltage areas (LVAs), and have been reported to correspond to fibrotic regions 4,5 . After pulmonary vein isolation (PVI), LA LVAs have been reported as predictors of recurrent AF 1–3,6 .…”

Section: Introductionmentioning

confidence: 99%

Grid‐mapping catheters versus PentaRay catheters for left atrial mapping on ensite precision mapping system

Saito

Yamashita

Numajiri

et al. 2022

Cardiovasc electrophysiol

Self Cite

View full text Add to dashboard Cite

Introduction: Areas displaying reduced bipolar voltage are defined as low-voltage areas (LVAs). Moreover, left atrial (LA) LVAs after pulmonary vein isolation (PVI) have been reported as a predictor of recurrent atrial fibrillation (AF). In this study, we compared grid mapping catheter (GMC) with PentaRay catheter (PC) for LA voltage mapping on Ensite Precision mapping system.Methods: Twenty-six consecutive patients with LVAs and border zone within the LA were enrolled. After achieving PVI, voltage mapping under high right atrial pacing for 600 ms was performed twice using each catheter type (GMC first, PC next).Furthermore, LVA was defined as a region with a bipolar voltage of <0.50, and border zone was defined as a region with a bipolar voltage of <1.0, or <1.5 mV.Results: Compared with PC, using GMC, voltage mapping contained more mapping points (20 242 [15 859, 26 013] vs. 5589 [4088, 7649]; p < .0001), and more mapping points per minute (1428 [1275, 1803] vs. 558 [372, 783]; p < .0001). In addition, LVA and border zone size using GMC was significantly less than that reported using PC: <1.0 mV (5.9 cm 2 [2.9, 20.2] vs. 13.9 cm 2 [6.3, 24.1], p = .018) and <1.5 mV voltage cutoff (10.6 cm 2 [6.6, 27.2] vs. 21.6 cm 2 [12.6, 35.0], p = .005). Conclusion:Bipolar voltage amplitude estimated by GMC was significantly larger than that estimated by PC on Ensite Precision mapping system. GMC may be able to find highly selective identification of LVAs with lower prevalence and smaller LVA and border zone size.

show abstract

Changes in atrial electrophysiological and structural substrate and their relationship to histology in a long‐term chronic canine atrial fibrillation model

Cited by 12 publications

References 41 publications

Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis

Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis

Duration of Persistent Atrial Fibrillation Is Associated with Alterations in Human Gut Microbiota and Metabolic Phenotypes

Grid‐mapping catheters versus PentaRay catheters for left atrial mapping on ensite precision mapping system

Contact Info

Product

Resources

About