Changes in behavior and electrocortical activity in the monkey following administration of 5-Hydroxytryptophan (5-HTP)

Macchitelli, Frank J.; Fischetti, Donald; Montanarelli, Nicholas

doi:10.1007/bf00406454

Cited by 20 publications

(4 citation statements)

References 9 publications

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“…Macchitelli et al (1966) reported that rhesus monkeys treated with DL-5-hydroxytryptofan 5~100 mg/kg showed agitation followed by inactivity, champing movements of the mouth, head shakes, drowsiness and vomiting. However, similar behavioral reports have been made for other species of primates.…”

Section: Discussionmentioning

confidence: 99%

Rats and marmosets respond differently to serotonin agonists and antagonists

Campos

Rodrigues

1987

Psychopharmacology

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The actions of the serotonin precursor 5-hydroxytryptophan (5-HTP), the agonist 5-methoxy-N,N-dimetyltryptamine (MeODMT) and quipazine (QPZ) and the antagonists cyproheptadine, methysergide and metergoline, were studied in the rat and in the common marmoset (Callithrix jacchus). The precursor and agonists elicited head shakes, forepaw padding, splayed hindlimbs, tremor and Straub tail in the rat. However, head shakes were not observed after MeODMT and Straub tail was not observed after QPZ. Carbidopa plus 5-HTP potentiated only head shakes, while tranylcypromine (TCP) plus 5-HTP potentiated all the behaviors above. In the marmoset, the action of these drugs elicited drowsiness, teeth chattering, ataxia, vomiting and decreased motor activity, although vomiting was not elicited by MeODMT and ataxia and drowsiness by QPZ. Although TCP plus 5-HTP potentiated all these behaviors, carbidopa plus 5-HTP was not effective. Rats treated with the antagonists (1.0, 5.0 and 10 mg/kg doses) did not show any of these behaviors, but marmosets treated with the same drugs developed "drowsiness", vomiting, and decreased motor activity; nonetheless, cyproheptadine (5.0 and 10 mg/kg doses) did not elicit "drowsiness", while increasing motor activity and the number of head shakes. Pretreatment of marmosets with these antagonists blocked only teeth chattering elicited by MeODMT (4.0 mg/kg) and QPZ (10 mg/kg). Pretreatment with haloperidol, p-chlorophenylalanine and alpha-methyl-P-tyrosine had no effect. The data obtained show that rats and marmosets present differential behavioral responses to the 5-HT drugs used.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Rats and marmosets respond differently to serotonin agonists and antagonists

Campos

Rodrigues

1987

Psychopharmacology

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“…Jouvet, 1969). On the other hand, administration of 5-HTP (50-100 mg/kg) produces a behavioral sedation together with the appearance of high-voltage slow waves in the cortex of monkeys (Macchitelli et at., 1966). The extent to which these alterations in electrographic activity may account for alterations in memory-storage processes will be considered below.…”

Section: Serotonin (5-hydroxytrypt Amine 5-ht)mentioning

confidence: 98%

Modulation of Learning and Memory: Effects of Drugs Influencing Neurotransmitters

Hunter

Zornetzer

Jarvik

et al. 1977

Drugs, Neurotransmitters, and Behavior

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“…Large doses of 5-HTP increased electroencephalography (EEG) synchronization, a hallmark of neural activity during non-rapid eye movement (NREM) sleep, while suppressing rapid eye movement (REM) sleep in cats (Pujol et al, 1971). In monkeys, 5-HTP caused hyperactivity followed by an inactive period alternating between dozing and staring blankly (Macchitelli et al, 1966). Gain-of-function experiments suggested that 5-HT was not simply promoting sleep or triggering sleep onset.…”

Section: Introductionmentioning

confidence: 99%

Thermoregulation-Independent Regulation of Sleep by Serotonin Revealed in Mice Defective in Serotonin Synthesis

Zhang

Yan

Luo

et al. 2018

Molecular Pharmacology

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A role for 5-hydroxytryptamine (5-HT) or serotonin in sleep has been known for decades but was challenged by recent papers that concluded that the apparent sleep phenotype was secondary to defective thermoregulation. Those studies used mice lacking serotonergic neurons resulting from the loss of function mutations in the gene encoding the LIM homeobox transcription factor 1 (). Here we show that, while mutants failed to keep the physiologic body temperature, they exhibited more activities at the room and elevated temperatures. More importantly, we used mice deficient in the gene encoding tryptophan hydroxylase 2 (), which could not synthesize 5-HT in the brain. mutants were capable of thermoregulation and keeping physiologic body temperature when the environmental temperature was reduced and exhibited significantly more activities at both the room and elevated temperatures. Electroencephalographic (EEG) recording also showed decreased sleep in-deficient mice. Our results indicate that 5-HT is important for sleep regulation but not thermoregulation.

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Changes in behavior and electrocortical activity in the monkey following administration of 5-Hydroxytryptophan (5-HTP)

Cited by 20 publications

References 9 publications

Rats and marmosets respond differently to serotonin agonists and antagonists

Rats and marmosets respond differently to serotonin agonists and antagonists

Modulation of Learning and Memory: Effects of Drugs Influencing Neurotransmitters

Thermoregulation-Independent Regulation of Sleep by Serotonin Revealed in Mice Defective in Serotonin Synthesis

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