Changes in blood flow distribution produced by central sciatic nerve stimulation

Fell, Colin

doi:10.1152/ajplegacy.1968.214.3.561

Cited by 9 publications

(5 citation statements)

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“…In contrast to vestibular afferents, stimulation of limb nerves elicited an increase in resistance and a decrease in conductance in all three vascular beds that were studied, accompanied by tachycardia and blood pressure increases. These observations are consistent with findings from other studies (2,8,17), indicating that pressor responses accompanied by widespread sympathetically mediated vasoconstriction occur in response to electrical stimulation of somatic nerves in anesthetized cats and dogs. In an earlier study, we reported that the pattern of responses of visceral sympathetic nerves to vestibular stimulation is different from that elicited by activation of limb afferents (10).…”

Section: Discussionsupporting

confidence: 93%

Vestibular stimulation leads to distinct hemodynamic patterning

Kerman¹,

Yates

2000

American Journal of Physiology-Regulatory, Integrative and Comp

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Previous studies demonstrated that responses of a particular sympathetic nerve to vestibular stimulation depend on the type of tissue the nerve innervates as well as its anatomic location. In the present study, we sought to determine whether such precise patterning of vestibulosympathetic reflexes could lead to specific hemodynamic alterations in response to vestibular afferent activation. We simultaneously measured changes in systemic blood pressure and blood flow (with the use of Doppler flowmetry) to the hindlimb (femoral artery), forelimb (brachial artery), and kidney (renal artery) in chloralose-urethane-anesthetized, baroreceptor-denervated cats. Electrical vestibular stimulation led to depressor responses, 8 +/- 2 mmHg (mean +/- SE) in magnitude, that were accompanied by decreases in femoral vasoconstriction (23 +/- 4% decrease in vascular resistance or 36 +/- 7% increase in vascular conductance) and increases in brachial vascular tone (resistance increase of 10 +/- 6% and conductance decrease of 11 +/- 4%). Relatively small changes (<5%) in renal vascular tone were observed. In contrast, electrical stimulation of muscle and cutaneous afferents produced pressor responses (20 +/- 6 mmHg) that were accompanied by vasoconstriction in all three beds. These data suggest that vestibular inputs lead to a complex pattern of cardiovascular changes that is distinct from that which occurs in response to activation of other types of somatic afferents.

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Section: Discussionsupporting

confidence: 93%

Vestibular stimulation leads to distinct hemodynamic patterning

Kerman¹,

Yates

2000

American Journal of Physiology-Regulatory, Integrative and Comp

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“…iNOS expression in normal skeletal muscles of various species has been investigated recently. iNOS protein expression was not detected in different skeletal muscles of pathogen-free rats (10,12). The current study confirms the absence of iNOS protein expression in normal rat muscles.…”

Section: Discussionsupporting

confidence: 82%

Endotoxin-induced skeletal muscle contractile dysfunction: contribution of nitric oxide synthases

El-Dwairi

Comtois

Guo

et al. 1998

American Journal of Physiology-Cell Physiology

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The aims of this study were to assess the role of nitric oxide (NO) and the contribution of different NO synthase (NOS) isoforms in skeletal muscle contractile dysfunction in septic shock. Four groups of conscious rats were examined. Group 1 served as control; groups 2, 3, and 4 were injected with Escherichia coli endotoxin [lipopolysaccharide (LPS), 20 mg/kg ip] and killed after 6, 12, and 24 h, respectively. Protein expression was assessed by immunoblotting and immunostaining. LPS injection elicited a transient expression of the inducible NOS isoform, which peaked 12 h after LPS injection and disappeared within 24 h. This expression coincided with a significant increase in nitrotyrosine formation (peroxynitrite footprint). Muscle expression of the endothelial and neuronal NOS isoforms, by comparison, rose significantly and remained higher than control levels 24 h after LPS injection. In vitro measurement of muscle contractility 24 h after LPS injection showed that incubation with NOS inhibitor ( S-methyliosothiourea) restored the decline in submaximal force generation, whereas maximal muscle force remained unaffected. We conclude that NO plays a significant role in muscle contractile dysfunction in septic animals and that increased NO production is due to induction of the inducible NOS isoform and upregulation of constitutive NOS isoforms.

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“…With respect to the femoral region, such variability may also be attributable to differences in degree of partici pation of skin and muscle vascular beds as in the adult cat (14), since the femoral artery in the pig supplies both cutaneous and muscular beds (24). During high frequency or intensity stimulation of the sciatic nerve, we observed a general increase in Fern F and carotid F but not in Ren F (table III), and a redistribution of cardiac output that has also been observed in adult dogs under pentobarbital anesthesia (8). Our failure to find age-dependence for all vas cular response patterns may be due to unequal maturation of various central and peripheral elements which are required to produce the complex responses (e.g., no information was obtained about venomotor activity in this in vestigation).…”

Section: Pattern O F Total Cardiovascular Response To Afferent Stimulsupporting

confidence: 59%

“…Stimulation of the central cut end of major somatic nerve trunks such as the sciatic nerve can produce either increased or decreased AoP in adult mammals (6,8,14) and in newborn pigs (10,19) depending upon the fiber type excited by a given set of stimulation parameters (3,20). We found clear-cut evidence for an agedependent difference in magnitude of the maxi mum pressor effect to high frequency or high intensity stimulation of the sciatic nerve (ta ble III).…”

Section: Magnitude O F Arterial Pressure Effects O F Afferent Stimulamentioning

confidence: 67%

Age-Dependent Cardiovascular Effects of Afferent Stimulation in Neonatal Pigs

Buckley¹,

Gootman²,

Gootman³

et al. 1976

Neonatology

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Postnatal development of heart rate (HR), mean aortic pressure and arterial flow responses to carotid baroreceptor stimulation (CS) or inhibition (BCCO), and to sciatic nerve stimulation (SNS), was studied in 60 newborn piglets under halothane-N₂O anesthesia. There was no HR change in most piglets during CS or BCCO, but tachycardia was observed during high frequency or intensity SNS and after bilateral vagotomy. In younger animals, smaller pressor effects were observed during high frequency or intensity SNS than in older ones. There were also age-dependent changes in femoral and renal flows and resistances to CS, BCCO, SNS or bilateral vagotomy. The results indicate postnatal maturation of regulatory mechanisms for HR and peripheral flow.

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Changes in blood flow distribution produced by central sciatic nerve stimulation

Cited by 9 publications

References 0 publications

Vestibular stimulation leads to distinct hemodynamic patterning

Vestibular stimulation leads to distinct hemodynamic patterning

Endotoxin-induced skeletal muscle contractile dysfunction: contribution of nitric oxide synthases

Age-Dependent Cardiovascular Effects of Afferent Stimulation in Neonatal Pigs

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