Changes in bone mass, biomechanical properties, and microarchitecture of calcium- and iron-deficient rats fed diets supplemented with inulin-type fructans

Lobo, Alexandre Rodrigues; Cocato, Maria Lucia; Jorgetti, Vanda; Sá, Lílian Rose Marques de; Nakano, Eduardo Yoshio; Colli, Célia

doi:10.1016/j.nutres.2009.10.012

Cited by 19 publications

(30 citation statements)

References 31 publications

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“…Although no significant differences in serum phosphorus concentrations were seen among treatments, a 12% increase was estimated in the group treated with inulin. This is consistent with studies in rats, which showed that the intake of inulin and fructooligosaccharides increased the absorption of calcium, magnesium and phosphorus (Scholz-Ahrens & Schrezenmeir, 2007;Demigné et al, 2008;Lobo et al, 2009).…”

Section: Resultssupporting

confidence: 91%

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Inulin as a growth promoter in diets for rabbits

et al. 2013

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-Sixty New Zealand rabbits aged 40 days were divided into 4 groups of 15 animals. The control group received a free diet of antibiotic growth promoter (AGP) and inulin. The second group was supplemented with 2.5 g/kg of inulin. The third was administered AGP with 0.1 g/kg of flavomycin. Finally, the fourth group received a 2.5 and 0.1 g/kg inulin/AGP diet. Body weight gain was higher in the control group. Rabbits supplemented with inulin had lower values of triglycerides compared with the control and AGP groups, and their glucose level was significantly lower than those treated with AGP. Additionally, serum calcium and magnesium concentrations were higher than the other groups, particularly with regard to AGP. The bone content with regard to calcium, phosphorus and magnesium in the groups treated with inulin was higher compared with the control; moreover, phosphorus and magnesium were higher than in the AGP group. The thickness of the mucosa and crypt depth in the caecum were significantly higher in rabbits treated with inulin than in the other groups, but especially compared with the AGP group. Also, triglyceride values were lower for rabbits treated with inulin/AGP than for those treated with AGP and the bone magnesium concentration was significantly higher compared with the control group. In addition, inulin was shown to have positive effects on the rabbit, promoting increase in bone and serum calcium, magnesium and phosphorus, decrease in triglyceride levels, and improvement in the caecum (changes in morphology, crypt depth and mucosal thickness).

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Section: Resultssupporting

confidence: 91%

“…Maertens et al (2004) and Juskiewicz et al (2007) reported that the employment of fructo-oligosaccharides or inulin in the diet of rabbits produced an increase in volatile fatty acids. In accordance with previous studies, inulin inclusion is used to avoid possible gastrointestinal infections and may be an alternative to the use of AGP.…”

Section: Introductionmentioning

confidence: 99%

Inulin as a growth promoter in diets for rabbits

et al. 2013

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“…Por otro lado, la reducción de las concentraciones de Ca en la dieta exacerban la acidez del lumen intestinal, pudiendo perjudicar la mucosa. El Ca actúa como buffer en la acidificación causada por la fermentación bacteriana en el intestino grueso 39 . De esta forma, para que tengan lugar los efectos positivos de los fructanos en la absorción de Ca, se debe considerar la concentración de Ca en las raciones 39,40 .…”

Section: Hipótesisunclassified

“…El Ca actúa como buffer en la acidificación causada por la fermentación bacteriana en el intestino grueso 39 . De esta forma, para que tengan lugar los efectos positivos de los fructanos en la absorción de Ca, se debe considerar la concentración de Ca en las raciones 39,40 . Es también posible que los AGCC contribuyan directamente al aumento de la absorción de Ca vía un mecanismo de intercambio catiónico y al aumento del intercambio de H+ celular con Ca+² luminal 30 .…”

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Prebióticos y su efecto en la biod sponibilidad del calcio

et al. 2011

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En la búsqueda de medidas de prevención de enfermedades crónicas no trasmisibles, se piensa en los prebióticos como una forma efectiva, saludable y relativamente barata para la optimización de la absorción de Ca. El aumento de la expectativa de vida de la población y el incremento de enfermedades como la osteoporosis traen graves consecuencias a la salud del individuo, acarreando importantes desembolsos económicos. En esta revisión se condensa el conocimiento presente sobre el efecto fisiológico del consumo de carbohidratos prebióticos y su posible interferencia en la biodisponibilidad del Ca, como también las posibilidades de su empleo en estrategias para combatir las deficiencias del mineral. Se elaboró una recopilación de los estudios originales realizados con mayor impacto en el tema, dando preferencia a los publicados en los últimos 6 años. Utilizamos las bases de datos PubMed, Lilacs e SciELO, usando las palabras claves calcio, prebióticos e probióticos.Palabras clave: Calcio. Dietética. Minerales. Polisacáridos. Prebióticos. A B S T R A C T

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“…Recently, we have observed that Fe-deficient rats had decreased intestinal Mg absorption [8] and reduced bone Mg contents when compared to controls [9]. Moreover, the consumption of inulin-type fructans, a fermentable dietary fiber that promotes mineral absorption, re-established Mg absorption [8], but did not recover bone Mg levels that had been lowered by Fe deficiency [9].…”

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confidence: 99%

Hemoglobin Regeneration Efficiency in Anemic Rats: Effects on Bone Mineral Composition and Biomechanical Properties

Lobo

Gaievski

Colli

2010

Biol Trace Elem Res

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This study reports the effects of dietary iron (Fe) deficiency and recovery on bone mineral composition and strength in anemic rats submitted to a hemoglobin (Hb) repletion assay. Weanling male Wistar rats were fed a low-Fe diet (12 mg/kg) for 15 days followed by 2 weeks of Fe repletion with diets providing 35 mg Fe/kg as either ferrous sulfate (n = 8) or ferric pyrophosphate (FP; n = 12). At final day of each period (depletion and repletion), Fe-adequate animals were also euthanized. Iron status (blood Hb, Hb Fe pool, Hb regeneration efficiency), tibia mineral concentrations (Ca, Mg, Fe, Cu, and Zn) and biomechanical properties were evaluated. Iron-deficient rats had lower tibia Fe and Mg levels and bone strength when compared to controls. Yield load and resilience were positively related to tibia Mg levels (r = 0.47, P = 0.02 and r = 0.56, P = 0.004, respectively). Iron repletion did not recover tibia Mg concentrations impaired by Fe deficiency. Moreover, bone elastic properties were negatively affected by FP consumption. In conclusion, bone mineral composition and strength were affected by Fe deficiency, whereas dietary Fe source influenced tibia Mg and resistance in the period during which rats were recovering from anemia.

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Changes in bone mass, biomechanical properties, and microarchitecture of calcium- and iron-deficient rats fed diets supplemented with inulin-type fructans

Cited by 19 publications

References 31 publications

Inulin as a growth promoter in diets for rabbits

Inulin as a growth promoter in diets for rabbits

Prebióticos y su efecto en la biod sponibilidad del calcio

Hemoglobin Regeneration Efficiency in Anemic Rats: Effects on Bone Mineral Composition and Biomechanical Properties

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