Changes in Brain-derived Neurotrophic Factor From Active and Sham Transcranial Direct Current Stimulation in Older Adults With Knee Osteoarthritis

Suchting, Robert; Teixeira, Antônio Lúcio; Ahn, Brian; Colpo, Gabriela Delevati; Park, Ju‐Young; Ahn, Hyochol

doi:10.1097/ajp.0000000000000987

Cited by 13 publications

(13 citation statements)

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“…Recently, Dimmek et al detected that in OA-related chronic widespread pain patients, reduced serum BDNF levels may induce the anxiety and depression via affecting the function of immune cells ( 27 ), which supported the present findings on relationships of BDNF with depression and pain. Additionally, previous studies showed serum/plasma BDNF levels can elevated in OA patients after the continuous non-surgical treatment, with improving the pain symptom ( 28 , 29 ), which suggested that BDNF levels can be affected by the severity of OA. Similarly, the present study observed that in the development of OA, lower serum BDNF levels reflected the more serious of pain and predicted the high risk of MDD.…”

Section: Discussionmentioning

confidence: 92%

Potential value of serum brain-derived neurotrophic factor, vascular endothelial growth factor, and S100B for identifying major depressive disorder in knee osteoarthritis patients

Zhang

Xiong²,

Wang³

et al. 2022

Front. Psychiatry

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BackgroundThe chronic pain and functional limitations in osteoarthritis (OA) patients can increase risk of psychiatric disorders, e.g., major depression disorder (MDD), which may further aggravate the clinical symptoms of OA. Early detection of MDD is essential in the clinical practice of OA.Materials and methodsTwo hundred and fifteen participants with knee OA were recruited, including 134 MDD patients (i.e., MDD group) and 81 ones without MDD (i.e., control group). Among them, 81 OA participants in the control group received a 3-year follow-up and were divided into trans-MDD group (who transforming into MDD; N = 39) and non-MDD group (who keeping non-MDD; N = 42) at the end of the follow-up. The 17-item Hamilton Depression Scale (HAMD-17), Self-Rating Depression Scale (SDS), and Visual Analogue Scale (VAS) were performed. Furthermore, serum levels of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), S100B, and IGF-1 were detected.Results(1) Compared with OA participants without MDD, there were significant decrease in serum BDNF and significant increase in serum VEGF and S100B and VAS scores in OA participants with MDD. (2) A mediation of the association was found between the VAS scores and the HAMD-17 scores through the BDNF as mediator in OA participants with MDD. (3) Significantly lower baseline BDNF levels and higher baseline S100B levels were detected in OA participants who transforming to MDD after a 3-year follow-up when compared with those who keeping non-MDD. (4) In the trans-MDD group, significant associations of the change of serum BDNF levels with rate of change of HAMD-17 scores were found, and baseline serum S100B levels positively correlated with the HAMD-17 scores at the end of the follow-up. (5) In OA participants, the composite indicator of BDNF, VEGF, and S100B differentiated MDD patients from controls with the area under the curve (AUC) value of 0.806, and the combined indicator of baseline BDNF and S100B distinguished trans-MDD participants from non-MDD ones with an AUC value of 0.806.ConclusionSerum BDNF, VEGF, and S100B may be potential biomarkers to identify MDD in OA patients. Meanwhile, serum BDNF and S100B shows great potential to predict the risk of MDD for OA.

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Section: Discussionmentioning

confidence: 92%

Potential value of serum brain-derived neurotrophic factor, vascular endothelial growth factor, and S100B for identifying major depressive disorder in knee osteoarthritis patients

Zhang

Xiong²,

Wang³

et al. 2022

Front. Psychiatry

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“…Full texts of 33 records were evaluated, and finally, 13 RCTs met the inclusion criteria (Figure 1). [19][20][21][22][27][28][29][30][31][32][33][34][35] The reasons for excluded trials appear in Supplementary Table 3.…”

Section: Resultsmentioning

confidence: 99%

“…In total, 13 RCTs were included, with sample sizes ranging from 15 to 60, but that does not mean that there is quantitive evidence from 13 trials for every outcome measure (pain, physical function, stiffness, mobility performance, quality of life, pressure pain tolerance, and plasma levels of BDNF). The individuals included within studies by Ahn et al, 19,27 Suchting et al, 17,32 Geraldine (1) et al, 34 and Geraldine (2) et al 35 were repeated. However, different outcomes and measuring method of outcomes were reported in these studies.…”

Section: Resultsmentioning

confidence: 99%

“…28,31 KOA severity was reported in nine studies 19,21,22,[29][30][31][34][35][36] based on the Kellgren and Lawrence radiologic assessment scale 37 and mostly ranged from grade 2 to 3. For tDCS parameters, the current intensity was set 2 mA in nine studies [19][20][21][22]27,29,30,32,[34][35][36] and 1 mA in two studies. 28,31 All studies except one 30 applied stimulations for 20 minutes.…”

Section: Resultsmentioning

confidence: 99%

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Transcranial Direct Current Stimulation for Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Yang,

Li,

Wang

et al. 2024

Arthritis Care & Research

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BackgroundThe effects of transcranial direct current stimulation (tDCS) in the treatment of knee osteoarthritis (KOA) is still unclear.ObjectiveTo evaluate the efficacy and safety of tDCS in improving symptoms in patients with KOA.Data sources and study selectionThe following electronic databases were searched for eligible randomized controlled trials (RCTs): PubMed, EMBASE, Web of Science, and the Cochrane Library. The search was performed from the inception dates to April 30, 2023.Data extraction and synthesisData extraction and quality assessment were performed by 2 independent reviewers. Standard mean differences (SMDs) with 95% confidence intervals (95% CIs) for pooled data were calculated. A random‐effects model was used for the data analyses.Main outcomes and measuresThe primary outcomes were pain and physical function. Secondary outcomes included stiffness, mobility performance, quality of life, pressure pain tolerance, and plasma levels of brain‐derived neurotrophic factor (BDNF).ResultsThis meta‐analysis included 13 RCTs. tDCS was significantly associated with pain decrease compared with sham tDCS (SMD = ‐0.62, 95% CI: [‐0.87, ‐0.37], P < 0.00001). When compared tDCS plus other non‐tDCS with sham tDCS plus other non‐tDCS, there was no longer an significant association with pain decrease (SMD = ‐0.45, 95% CI: [‐1.08, 0.17], P = 0.16). The changes in physical function were not significantly different between the tDCS and sham tDCS groups. (SMD = ‐0.09, 95% CI: [‐0.56, 0.38], P = 0.71). When compared tDCS plus other non‐tDCS with sham tDCS plus other non‐tDCS, there was still no significant association with improvement in physical function (SMD = ‐0.66, 95% CI: [‐1.63, 0.30], P = 0.18). There was no significant difference with improvement in stiffness (SMD = ‐0.21, 95% CI: [‐0.77, 0.34], P = 0.45), mobility performance (SMD = 4.58, 95% CI: [‐9.21, 18.37], P = 0.51), quality of life (SMD = ‐7.01, 95% CI: [‐22.61, 8.59], P = 0.38), pressure pain tolerance (SMD = 0.30, 95% CI: [‐0.09, 0.69], P = 0.13). There was a statistically significant reduction in plasma levels of BDNF (SMD = ‐13.57, 95% CI: [‐24.23, ‐2.92], P = 0.01)ConclusionsIn conclusion, tDCS could significantly alleviate pain, but it might had no efficacy in physical function, stiffness, mobility performance, quality of life, pressure pain tolerance among KOA patients.

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“…While still embryonic, research suggests that BDNF levels, for instance, could highlight pain inhibition and neuroplastic changes, thus illustrating treatment response [ 33 ]. Of note, we previously found a relationship between BDNF, heat pain threshold, and clinical pain (numeric rating scale) in individuals with knee OA [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Home-Based Transcranial Direct Current Stimulation on Experimental Pain Sensitivity in Older Adults with Knee Osteoarthritis: A Randomized, Sham-Controlled Clinical Trial

Martorella

Mathis

Miao

et al. 2022

JCM

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Although transcranial direct current stimulation (tDCS) is encouraging regarding clinical pain intensity for individuals with knee osteoarthritis, very few studies have explored its impact on experimental pain sensitivity, which may hinder our understanding of underlying therapeutic mechanisms. The purpose of this study was to assess the efficacy of 15 home-based tDCS sessions on experimental pain sensitivity and explore its relationships with clinical pain intensity. We randomly assigned 120 participants to active tDCS (n = 60) and sham tDCS (n = 60). Quantitative sensory testing (QST) was used, including heat pain threshold and tolerance, pressure pain threshold, and conditioned pain modulation. Patients in the active tDCS group exhibited reduced experimental pain sensitivity as reflected by all QST measures at the end of treatment. Furthermore, correlations were observed between changes in clinical pain intensity and experimental pain sensitivity. These findings warrant further studies on tDCS and experimental pain sensitivity in patients with knee osteoarthritis and exploring the magnitude and sustainability of effects on a longer term.

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Changes in Brain-derived Neurotrophic Factor From Active and Sham Transcranial Direct Current Stimulation in Older Adults With Knee Osteoarthritis

Cited by 13 publications

References 50 publications

Potential value of serum brain-derived neurotrophic factor, vascular endothelial growth factor, and S100B for identifying major depressive disorder in knee osteoarthritis patients

Potential value of serum brain-derived neurotrophic factor, vascular endothelial growth factor, and S100B for identifying major depressive disorder in knee osteoarthritis patients

Transcranial Direct Current Stimulation for Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Efficacy of Home-Based Transcranial Direct Current Stimulation on Experimental Pain Sensitivity in Older Adults with Knee Osteoarthritis: A Randomized, Sham-Controlled Clinical Trial

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