Changes in cardiovascular disease risk and risk factors among women with and without breast cancer

Anderson, Chelsea; Nichols, Hazel B.; Deal, Allison M.; Park, Young Jun; Sandler, Dale P.

doi:10.1002/cncr.31775

Cited by 10 publications

(8 citation statements)

References 23 publications

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“…The average 10-year probability of CVD in relation to the cancer type was significantly higher in patients with hepatic, colon, lung, breast, and gastric cancer [ 29 ]. On the other hand, FRS was not significantly higher among those with breast [ 30 ], testicular [ 31 ], childhood cancer [ 32 ], or ovarian cancer [ 33 ] compared with controls. The current analysis, which demonstrated increased odds of elevated 10-year ASCVD risk among participants with a history of bladder or kidney, prostate, colorectal, lung, melanoma, testicular, and other cancer, suggests that ASCVD risk estimation may be more clinically relevant for individuals diagnosed with specific cancers.…”

Section: Discussionmentioning

confidence: 99%

Ten-year cardiovascular risk among cancer survivors: The National Health and Nutrition Examination Survey

et al. 2021

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Background Cancer survivors have a higher risk of developing and dying from cardiovascular disease (CVD) compared to the general population. We sought to determine whether 10-year risk of atherosclerotic CVD (ASCVD) is elevated among those with vs. without a cancer history in a nationally representative U.S. sample. Methods Participants aged 40–79 years with no CVD history were included from the 2007–2016 National Health and Nutrition Examination Survey. Cancer history was self-reported and 10-year risk of ASCVD was estimated using Pooled Cohort Equations. We used logistic regression to estimate associations between cancer history and odds of elevated (≥7.5%) vs. low (<7.5%) 10-year ASCVD risk. An interaction between age and cancer history was examined. Results A total of 15,095 participants were included (mean age = 55.2 years) with 12.3% (n = 1,604) reporting a cancer history. Individuals with vs. without a cancer history had increased odds of elevated 10-year ASCVD risk (OR = 3.42, 95% CI: 2.51–4.66). Specifically, those with bladder/kidney, prostate, colorectal, lung, melanoma, or testicular cancer had a 2.72–10.47 higher odds of elevated 10-year ASCVD risk. Additionally, age was an effect modifier: a cancer history was associated with 1.24 (95% CI: 1.19–4.21) times higher odds of elevated 10-year ASCVD risk among those aged 60–69, but not with other age groups. Conclusions Adults with a history of self-reported cancer had higher 10-year ASCVD risk. ASCVD risk assessment and clinical surveillance of cardiovascular health following a cancer diagnosis could potentially reduce disease burden and prolong survival, especially for patients with specific cancers and high ASCVD risk.

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Section: Discussionmentioning

confidence: 99%

Ten-year cardiovascular risk among cancer survivors: The National Health and Nutrition Examination Survey

et al. 2021

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“…According to the National Cancer Institute, certain treatments can damage the heart and the circulatory system leading to a series of side effects, such as hypertension, abnormal heart rhythm and heart failure, which are generally caused or exacerbated by chemotherapy and radiotherapy [50]. No studies currently exist that analyze how rowing affects heart function and blood pressure in BC survivors, but there are several articles showing that physical exercise improves these functions [37,[51][52][53][54][55][56]. Notable among them is the study by Stefani et al [51] which reports that BC survivors who received chemotherapy treatment experienced a significant improvement in diastolic function measurements after four years of dragon boat training, increasing by 2.5 cm/s.…”

Section: Introductionmentioning

confidence: 99%

Cardiac Effects of a Rowing Training Program in Breast Cancer Survivors

et al. 2021

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The aim of this study was to determine whether a rowing training program could improve cardiac function in women (n = 28) with the mean age of 52.30 ± 3.78 years who survived breast cancer (stage 1: 4.55%; 2: 36.36%; 3: 54.54%; and 4: 4.55%) diagnosed 4.68 ± 3.00 years previously and underwent subsequent surgery (preservation: 56.52%; total mastectomy: 39.13%; and double mastectomy: 4.35%). Participants completed a 12-week training program consisting of three weekly sessions lasting 60–90 min with a progressive intensity increase according to the Börg scale. The assessments performed were blood pressure and pulse measurements both at rest and after performing the six-minute walk test to collect data on cardiac behavior and aerobic performance. The results showed statistically significant differences in cardiovascular system efficiency measured on the basis of heart rate both before (−12.63 ± 14.68 bpm) and after the six-minute walk test (−11.46 ± 28.39 bpm), increase in the distance achieved in the aerobic endurance test (51.56 ± 48.26 m) as well as decrease in diastolic (−13.6 ± 7.85 mm Hg) and systolic (−6.60 ± 9.10 mm Hg) blood pressure. These results suggest that rowing training programs could be a strategy to consider in this population for the benefits observed in heart rate, blood pressure and aerobic performance, which would lead to improved general health and quality of life.

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“…However, we lacked information about the specific chemotherapy regimens received by the patients. Cardiovascular disease is the leading cause of death for women with ductal carcinoma in situ or stage I disease, and for women aged > 80 years with stage II disease [ 9 ]. A recent systematic review found that women with a history of breast cancer have a higher risk of breast cancer mortality than their cancer-free counterparts [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…A recent systematic review found that women with a history of breast cancer have a higher risk of breast cancer mortality than their cancer-free counterparts [ 10 ]. However, in the National Institute of Environmental Health Sciences Sister Study Cohort, changes over time in cardiovascular disease risk, adiposity measures, and blood pressure were similar between women who developed an incident breast cancer and those who did not [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Disease among Breast Cancer Survivors

Majeed¹,

Ayyala²,

Kapuku³

et al. 2020

CDM

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Background: Among breast cancer survivors age > 50 years, deaths due to cardiovascular disease account for 35% of non-cancer related deaths. The increases in cardiovascular disease among breast cancer survivors is due to the cardiotoxic effects of breast cancer treatment and to overlapping risk factors for breast cancer and cardiovascular disease. Methods: We conducted a study of a sample of 164 breast cancer patients in order to examine the frequency of cardiovascular disease. The overall objective was to examine the frequency of high blood pressure, myocardial infarction, cardiomyopathy, congestive heart failure, stroke, and venous thrombosis/thromboembolism among women who have been diagnosed with stage I-IV breast cancer and who had completed primary therapy for the disease. Data were collected by postal survey and abstraction of electronic medical records. Results: A high percentage of the women (62.8%) had a reported history of high blood pressure. Fifty percent of the women had a reported history of high cholesterol. About 8.3% of the women were current smokers and 36.0% were former smokers. About 23.8% of the women had a reported history of diabetes. About 4.9% of the women had a reported history of congestive heart failure and 6.1% had a history of stroke. Discussion: Additional studies are needed of cardiovascular risk factors and adverse cardiovascular events among breast cancer survivors. Of particular concern is whether patients with hypertension, hypercholesterolemia, and diabetes are receiving appropriate therapy to reduce their cardiovascular risk and prevent morbidity and mortality from adverse cardiovascular events.

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Changes in cardiovascular disease risk and risk factors among women with and without breast cancer

Cited by 10 publications

References 23 publications

Ten-year cardiovascular risk among cancer survivors: The National Health and Nutrition Examination Survey

Ten-year cardiovascular risk among cancer survivors: The National Health and Nutrition Examination Survey

Cardiac Effects of a Rowing Training Program in Breast Cancer Survivors

Cardiovascular Disease among Breast Cancer Survivors

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