Changes in central corneal thickness values after instillation of oxybuprocaine hydrochloride 0.4%

Comparison of two handheld applanation tonometers and the association of central corneal thickness, age, and intraocular pressure in normal and diseased canine eyes

“…They deduced that the changes in corneal thickness reported elsewhere were actually caused by the preservatives present in the ophthalmic solutions which may, in turn, structurally or functionally damage the corneal epithelium and endothelium . Another group also assessed the effect of 0.4% oxybuprocaine eye drops on CCT and found no significant change in CCT for up to 10 min following instillation; however, greater differences were observed 5 min and 9 min after instillation . The author knows of no study showing the influence of topical anesthesia on the canine cornea.…”

“…50 Another group also assessed the effect of 0.4% oxybuprocaine eye drops on CCT and found no significant change in CCT for up to 10 min following instillation; however, greater differences were observed 5 min and 9 min after instillation. 51 The author knows of no study showing the influence of topical anesthesia on the canine cornea. In this study, all measurements were taken 1 min after the topical instillation of 1 drop of 0.4% oxybuprocaine.…”

Corneal Thickness Response after Anesthetic Eye Drops: Our Own Results and Meta-Analysis

“…They measured it at 2-minute intervals for 15 minutes after eye drop instillation and observed how these measurements reached a peak 1 minute after drop instillation, but it was not statistically significant compared to basal values. Ogbuehi et al [ 13 ] evaluated CCT values from 30 eyes by SM 5 minutes after tetracaine hydrochloride 0.5% instillation and they observed that the changes were not statistically significant. In addition, Osuagwu and Ogbuehi [ 24 ] analyzed CCT measurements by SM after instilling one drop of tetracaine HCL 1% in 50 subjects.…”

Comparison of the Influence of Nonpreserved Oxybuprocaine and a Preserved Artificial Tear (Thera Tears) on Human Corneal Thickness Measured by Two Pachymeters

“…Some work has reported a temporary increase, 21-24 while others did not find significant variations. 14,[25][26][27][28][29] However, the studies that have reported significant variations in CCT have also differed in their explanations why the variations occur. Some have attributed the changes to structural/functional damage to both the corneal epithelium and endothelium, caused by preservatives in anesthetics, 27,30,31 whereas others have reported that diffusion of topical anesthetic into the deep stroma layers causes an inhibition of endothelial cell metabolism, which results in corneal edema and a subsequent increase in corneal thickness.…”