Changes in Cholesterol Levels After Coronary Artery Bypass Surgery

Figueroa, Óscar; Franco‐Saenz, Roberto; Mulrow, Patrick J.; Montesinos, Efraín

doi:10.1097/00000441-199202000-00001

Cited by 9 publications

(1 citation statement)

References 21 publications

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“…This is consistent with the significant early decline in the levels of TC and LDL and HDL cholesterol found in our study. In the postoperative period the cause is likely to reflect a response to stress, combined with dietary changes, although haemodilution has been postulated 11 …”

Section: Discussionmentioning

confidence: 99%

A Study of Lipid Profile Before and After Coronary Artery Bypass Grafting

Ooi

Cooper

Lloyd

et al. 1996

Int J Clinical Practice

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SUMMARY This study was undertaken to establish the variability in the levels of total cholesterol (TC), total triglyceride (TG), low‐density lipoprotein (LDL) cholesterol, and high‐density lipoprotein (HDL) cholesterol before and after coronary artery bypass graft (CABG) surgery, in order to determine postoperatively when an accurate assessment can be made of the lipid status. During a prospective study over 4 months, fasting venous samples were taken pre‐ and postoperatively on day 5, and in the 4th, 8th and 12th weeks. Ninety‐six patients admitted to the cardiothoracic and cardiac wards for CABG were recruited to the study. The mean preoperative levels were: TC 5.94 (± 0.1 mmol/l), LDL cholesterol 4.02 (± 0.09mmol/l) and HDL cholesterol 1.00 (± 0.03mmol/l). These were significantly different (p<0.01) from the levels on the 5th postoperative day when the mean level of TC was 4.14 (± 0.084mmol/l), LDL cholesterol was 2.45 (± 0.07mmol/l) and HDL cholesterol was 0.74 (±0.03mmol/l). By the 4th postoperative week, mean TC (5.73±0.13mmol/l), LDL cholesterol (3.79 ±0.14mmol/l) and HDL cholesterol (1.03 ± 0.04mmol/l) did not vary significantly from the mean preoperative values. There was no significant difference in the mean TG levels pre‐ and postoperatively. The mean TC, LDL cholesterol and HDL cholesterol rise to preoperative levels by the 4th week after CABG. Thus, an accurate assessment of patients' lipid status can be made from this period. An earlier postoperative assessment may be falsely reassuring.

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Section: Discussionmentioning

confidence: 99%

A Study of Lipid Profile Before and After Coronary Artery Bypass Grafting

Ooi

Cooper

Lloyd

et al. 1996

Int J Clinical Practice

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Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions

2022

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Purpose of Review The study aims to capture the history and lineage of hypertension researchers from the University of Toledo in Ohio and showcase their collective scientific contributions dating from their initial discoveries of the physiology of adrenal and renal systems and genetics regulating blood pressure (BP) to its more contemporary contributions including microbiota and metabolomic links to BP regulation. Recent Findings The University of Toledo College of Medicine and Life Sciences (UTCOMLS), previously known as the Medical College of Ohio, has contributed significantly to our understanding of the etiology of hypertension. Two of the scientists, Patrick Mulrow and John Rapp from UTCOMLS, have been recognized with the highest honor, the Excellence in Hypertension award from the American Heart Association for their pioneering work on the physiology and genetics of hypertension, respectively. More recently, Bina Joe has continued their legacy in the basic sciences by uncovering previously unknown novel links between microbiota and metabolites to the etiology of hypertension, work that has been recognized by the American Heart Association with multiple awards. On the clinical research front, Christopher Cooper and colleagues lead the CORAL trials and contributed importantly to the investigations on renal artery stenosis treatment paradigms. Hypertension research at this institution has not only provided these pioneering insights, but also grown careers of scientists as leaders in academia as University Presidents and Deans of Medical Schools. Through the last decade, the university has expanded its commitment to Hypertension research as evident through the development of the Center for Hypertension and Precision Medicine led by Bina Joe as its founding Director. Summary Hypertension being the top risk factor for cardiovascular diseases, which is the leading cause of human mortality, is an important area of research in multiple international universities. The UTCOMLS is one such university which, for the last 6 decades, has made significant contributions to our current understanding of hypertension. This review is a synthesis of this rich history. Additionally, it also serves as a collection of audio archives by more recent faculty who are also prominent leaders in the field of hypertension research, including John Rapp, Bina Joe, and Christopher Cooper, which are cataloged at Interviews.

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2003

American Journal of Kidney Diseases

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Changes in Cholesterol Levels After Coronary Artery Bypass Surgery

Cited by 9 publications

References 21 publications

A Study of Lipid Profile Before and After Coronary Artery Bypass Grafting

A Study of Lipid Profile Before and After Coronary Artery Bypass Grafting

Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions

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