Changes in circulating cytokine levels and lymphocyte subsets in healthy liver donors after partial hepatectomy

Nakashima, Sayori; Katano, Yoshiaki; Nakano, Isao; Hirooka, Yoshiki; Ito, Akihiro; Ishigami, Masatoshi; Hayashi, Kazuhiko; Honda, Takashi; Goto, Hidemi

doi:10.1111/j.1872-034x.2007.00136.x

Cited by 4 publications

(7 citation statements)

References 18 publications

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“…This is the first human study to show a biphasic pattern of rise in HGF after partial hepatectomy. This biphasic trend of HGF is different from the earlier published studies where the HGF levels showed a sustained rise. Although in a partial hepatectomy rodent model, it has been shown that HGF is used during liver regeneration in a biphasic manner.…”

Section: Discussioncontrasting

confidence: 99%

“…Posthepatectomy liver failure develops more frequently in patients without appropriate elevation of plasma HGF levels . In healthy liver donors undergoing partial hepatectomy, there was a rise in HGF levels and HGF remained elevated until POD 5 and POD 7 . In the present study, a significant rise in the HGF levels was observed on POD 1, POD 7, and POD 14, but there was no significant change on POD 3 and POD 42.…”

Section: Discussioncontrasting

confidence: 50%

“…In experimental studies, after partial hepatectomy, matrix‐bound TGF‐β1 is activated and released into the circulation and thereby increased concentration is detected within 1 hour of partial hepatectomy . Nakashima et al have shown that the TGF‐β levels are increased on POD 1 and remained elevated until POD 7 after partial hepatectomy in healthy liver donors. In the present study, the TGF‐β1 levels did not show a significant difference until POD 7.…”

Section: Discussionmentioning

confidence: 99%

“…The literature about liver regeneration after partial hepatectomy in humans is limited and studied in the context of partial hepatectomy performed for liver tumors . Only a few studies have been able to evaluate the role of biomarkers in liver regeneration in a healthy individual undergoing hepatectomy for living donor liver transplantation (LDLT) . The aim of this study was to observe the serial changes in cytokines and growth factors involved in liver regeneration in donors undergoing right lobe donor hepatectomy.…”

mentioning

confidence: 99%

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Serial changes of cytokines and growth factors in peripheral circulation after right lobe donor hepatectomy

Sasturkar¹,

David²,

Sharma³

et al. 2016

Liver Transpl

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Cytokines and growth factors have prominent roles in liver regeneration. The aim of this study was to evaluate the biological markers of liver regeneration in healthy donors undergoing right lobe donor hepatectomy for living donor liver transplantation. Twenty-five voluntary liver donors were enrolled. Peripheral blood samples were taken a day before the operation and on postoperative days (PODs) 1, 3, 7, 14, and 42. Levels of hepatocyte growth factor (HGF), interleukin (IL) 6, tumor necrosis factor a (TNF-a), thrombopoietin (TPO), transforming growth factor b1 (TGF-b1), interferon (IFN) a, and IFNg were monitored. The remnant liver volume (RLV) before surgery and regeneration liver volume (RgV) on POD 14 were calculated on computed tomography (CT). RgV/RLV ratio was correlated with the remnant-liver-volume-to-body-weight ratio (RLVBWR). Inverse correlation was observed between RgV/RLV and RLVBWR (r 2 5 0.61; P < 0.001). There was a significant rise of HGF on POD 1 (P 5 0.001), POD 7 (P 5 0.049), and POD 14 (P 5 0.04). TNF-a was elevated on POD 1 (P 5 0.004). The levels of IL 6 (P < 0.001) and TPO (P < 0.001) were higher from POD 1 to POD 42. IFNa was higher on POD 14 (P 5 0.003) and POD 42 (P 5 0.001). There was a significant fall of IFNg on POD 1 (P 5 0.01) and increase on POD 14 (P 5 0.04). The levels of TGF-b1 were higher on POD 14 (P 5 0.008) and on POD 42 (P 5 0.002). In conclusion, HGF, IL 6, TNF-a, and TPO are involved in the early phase, whereas TGF-b1 and IFN are involved in the termination phase of liver regeneration. Liver regeneration was observed to be higher in donors with low RLVBWR. Liver Transpl 22:344-351, 2016. V C 2015 AASLD.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Serial changes of cytokines and growth factors in peripheral circulation after right lobe donor hepatectomy

Sasturkar¹,

David²,

Sharma³

et al. 2016

Liver Transpl

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“…Until now, a few studies have shown that serum HGF and IL-6 levels are elevated on postoperative day (POD) 1 [6–8]. In individuals without the appropriate elevation of serum HGF levels after partial hepatectomy, postoperative liver failure develops more frequently [9].…”

Section: Introductionmentioning

confidence: 99%

Serial Changes of Serum Growth Factor Levels and Liver Regeneration after Partial Hepatectomy in Healthy Humans

Matsumoto

Miyake

Umeda

et al. 2013

IJMS

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This study aimed to investigate the associations of the serial changes of serum levels of various growth factors with liver regeneration after hepatectomy in healthy liver donors. Sixteen healthy liver donors who underwent conventional liver resection were included. Serum levels of various growth factors before hepatectomy and on postoperative day (POD) 1, 3, 5 and 7 were measured. Liver volume data calculated by multi-detector computed tomography using workstation. The ratio of remnant liver volume on POD 0 to liver volume before the operation was 51% ± 20%. The ratio of liver volume on POD 14 to liver volume on POD 0 were inversely correlated with remnant liver volume on POD 0 (r = −0.91). The ratio of liver volume on POD 14 to liver volume on POD 0 were significantly correlated with serum hepatocyte growth factor (HGF) levels on POD 1 (r = 0.54), serum leptin levels on POD 1 (r = 0.54), and serum macrophage colony-stimulating factor (M-CSF) levels on POD 5 (r = 0.76) and POD 7 (r = 0.80). These results suggest that early-phase elevation of serum levels of HGF, leptin and M-CSF may be associated with the acceleration of liver regeneration after hepatectomy in humans.

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Highest intraoperative lactate level could predict postoperative infectious complications after hepatectomy, reflecting the Pringle maneuver especially in chronic liver disease

Meguro

Mizuguchi

Kawamoto

et al. 2014

J Hepatobiliary Pancreat Sci

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Changes in circulating cytokine levels and lymphocyte subsets in healthy liver donors after partial hepatectomy

Abstract: These findings suggest that immune suppression after partial hepatectomy involves decreases in CD4(+) helper T cells, particularly Th1 cells.

Cited by 4 publications

References 18 publications

Serial changes of cytokines and growth factors in peripheral circulation after right lobe donor hepatectomy

Serial changes of cytokines and growth factors in peripheral circulation after right lobe donor hepatectomy

Serial Changes of Serum Growth Factor Levels and Liver Regeneration after Partial Hepatectomy in Healthy Humans

Highest intraoperative lactate level could predict postoperative infectious complications after hepatectomy, reflecting the Pringle maneuver especially in chronic liver disease

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