Changes in conduction velocity and fibre size proximal to peripheral nerve lesions

Cragg, B.G.; Thomas, P. K.

doi:10.1113/jphysiol.1961.sp006724

Cited by 177 publications

(73 citation statements)

References 18 publications

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“…At this stage, the mean axonal conduction velocity of m.g. motoneurones (about 95 % of normal) showed no significant (0.05 < P < 0.10) change; its significant (P < 0-001) decrease (about 91 % of normal) was observed 2 weeks after axotomy (also, see Eccles et al 1959;Kiraly & Krnjevic, 1959;Cragg & Thomas, 1961;Kuno et al 1974;Mendell, Munson & Scott, 1976). The amplitude of monosynaptic e.p.s.p.s is known to be decreased within 2 weeks in motoneurones axotomized by section of the ventral root (Eccles, Libet & Young, 1958;McIntyre, Bradley & 7-2 196 R. GALLEGO AND OTHERS Brock, 1959;Shapovalov & Grantyn, 1968;Kuno & Llings.…”

Section: Resultsmentioning

confidence: 96%

Disuse enhances synaptic efficacy in spinal mononeurones.

Gallego¹,

Kuno²,

Núñez³

et al. 1979

The Journal of Physiology

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Section: Resultsmentioning

confidence: 96%

Disuse enhances synaptic efficacy in spinal mononeurones.

Gallego¹,

Kuno²,

Núñez³

et al. 1979

The Journal of Physiology

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“…This is also true of the sural nerve (Quilliam, 1956). Although no comparable anatomical data are available for the peroneal nerve, there is no reason to believe that the situation would be different, and Cragg & Thomas (1961) found that conduction velocity in this nerve is normally closely similar on the two sides. A possible objection to using the unoperated contralateral nerve for control purposes is the observation by Greenman (1913) that following crushing the peroneal nerve on one side in rats, the contralateral nerve showed a diminution in fibre diameter.…”

Section: Histological Observationsmentioning

confidence: 99%

The conduction velocity of regenerated peripheral nerve fibres

Cragg¹,

Thomas²

1964

The Journal of Physiology

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204

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“…Injuries in peripheral nerve fibres result in a reduction of conduction velocity proximal to the lesion (Acheson, Lee & Morison, 1942;Gutmann & Holubar, 1951;Eccles & McIntyre, 1953; Eccles, Krnjevic & Miledi, 1959;Kiraly & Krnjevic, 1959;Cragg & Thomas, 1961;Aitken & Thomas, 1962;Bagust & Lewis, 1974; Kuno, Miyata & Munioz-Martinez, 1974;Mendell, Munson & Scott, 1976;Schmidt & Stefani, 1976). The reduced conduction velocity appears to be associated with a decrease in axon diameter (Greenman, 1913;Gutmann & Sanders, 1943;Gutmann & Holuba6, 1951;Cragg & Thomas, 1961;Aitken & Thomas, 1962).…”

Section: Introductionmentioning

confidence: 99%

“…The reduced conduction velocity appears to be associated with a decrease in axon diameter (Greenman, 1913;Gutmann & Sanders, 1943;Gutmann & Holuba6, 1951;Cragg & Thomas, 1961;Aitken & Thomas, 1962). Mendell et al (1976) have attempted to determine if decreased conduction velocity proceeds centrally from the cut end toward the neurone cell body or in the reverse direction.…”

Section: Introductionmentioning

confidence: 99%

Membrane properties and conduction velocity in sensory neurones following central or peripheral axotomy

Czéh¹,

Kudo²,

Kuno³

1977

The Journal of Physiology

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SUMMARY1. The properties of dorsal root ganglion cells in the lumbosacral segments were examined with intracellular electrodes about 3 weeks after section of the central (dorsal roots) or peripheral processes in the cat.2. Chronic section of the peripheral nerve in the hind limb resulted in a reduction in conduction velocity of both the central and peripheral processes of sensory neurones.3. Sensory neurones arising from the triceps surae and plantaris muscles were subject to 'disuse' conditions for about 3 weeks by section of the ventral roots combined with severance of the Achilles tendon. Under such conditions, the central and peripheral conduction velocities of these sensory neurones tended to decrease, but the decrease was significantly less than that following peripheral nerve section.4. Chronic section of the dorsal roots produced no significant changes in conduction velocity of the central processes of muscle sensory neurones but caused a significant increase in the peripheral conduction velocity.5. The only electrophysiological property of dorsal root ganglion cells which altered following axotomy was the time-dependent membrane rectification in response to hyperpolarizing current pulses. The rectification characteristics were modified by chronic section of the peripheral nerve but not by chronic section of the dorsal root.6. It is concluded that injuries in nerve fibres per se do not necessarily result in a decrease of their conduction velocity and that a decrease in their conduction velocity is associated with changes in the properties of the cell bodies.7. It is suggested that a decrease in conduction velocity following nerve section may require the participation of changes in the neurone cell body.

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Changes in conduction velocity and fibre size proximal to peripheral nerve lesions

Cited by 177 publications

References 18 publications

Disuse enhances synaptic efficacy in spinal mononeurones.

Disuse enhances synaptic efficacy in spinal mononeurones.

The conduction velocity of regenerated peripheral nerve fibres

Membrane properties and conduction velocity in sensory neurones following central or peripheral axotomy

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