Changes in Detrusor Innervation with Relief of Outflow Tract Obstruction

Cumming, J. A.; Chisholm, G. D.

doi:10.1111/j.1464-410x.1992.tb15448.x

Cited by 52 publications

(31 citation statements)

References 16 publications

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“…In the obstructed changes in both nerve and muscle. Supporting this idea is that the isoforms of lactate dehydrogenase are altered bladder the well documented changes in the density of innervation [4,9,10,12] suggest that there may therefore in unstable bladders, indicative of changes to cope with low oxygen tensions [8]. However, it is not known be an involvement of NGF.…”

Section: Muscle Hypertrophymentioning

confidence: 67%

“…The mean the enzymes associated with metabolism [8]. In addition to the changes in muscle it has been reported that there (sd) ages of each group (normal, idiopathic and neuropathic) were 62 (9), 50 (11) and 31 (15) years, respectis a reduction in the density of motor nerves [9][10][11][12], which is associated with a decrease in the neuropeptide ively. None of the control group had received chemo-or radiotherapy.…”

Section: Methodsmentioning

confidence: 99%

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Focal changes in nerve, muscle and connective tissue in normal and unstable human bladder

et al. 1999

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Objective To compare and quantify, in a morphological (91), 81 (20) and 74 (38) nerves/mm2 in the three defined areas, respectively. In the neuropathic tissues study, the changes that occur in the connective tissue elements (elastin and collagen), muscle fibre diameters the nerve profile densities were 672 (249), 57 (23) and 37 (28) nerves/mm2, respectively. Fibre diameter, and nerve densities between normal, idiopathic and neuropathic bladders.elastin and collagen content and nerve density were measured in normal and unstable bladder tissue using Materials and methods Bladder tissue was obtained from 27 patients undergoing cystectomy for carcithese three defined areas. The mean (sem) fibre diameter was 6.81 (0.52) in normal bladder; in idiopathic noma, from 12 with idiopathic instability and from seven neuropathic patients who were undergoing ileobladder tissue the fibre diameters in the three areas were 6.72 (0.62), 7.06 (0.62) and 7.34 (1.15) mm, cystoplasty. A combination of histochemical and immunohistochemical techniques were used to detect respectively, and in neuropathic bladders were 6.75 (0.62), 8.24 (0.62) and 9.35 (0.62) mm, respectively. detrusor muscle, connective tissue and nerve profiles in the bladder tissue.The relative areas of elastin were 0.79 (0.70), 0.56 (0.45) and 18.3 (4.1)% for the control, normal and Results In both idiopathic and neuropathic bladder tissue the structural changes were highly punctate. From aCected areas of the neuropathic bladders, respectively, and the relative areas of collagen were 3.5 (1.3), 6.15

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Section: Muscle Hypertrophymentioning

confidence: 67%

Section: Methodsmentioning

confidence: 99%

Focal changes in nerve, muscle and connective tissue in normal and unstable human bladder

et al. 1999

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“…Treatment alternatives of OB include behavioural therapy, pelvic¯oor muscle training, antimuscarinic drugs, intravesical treatments, clean intermittent catheterisation, electrical nerve stimulation and, rarely, open surgery of the bladder. Surgery of the prostate can in some of these patients normalise the cystometric response in OB [Cumming and Chisholm, 1992;Chapple and Smith, 1994], and in others cause urge incontinence [Kimche et al, 1985;Staskin et al, 1988;Khan et al, 1991;Nitti et al, 1996]. Thus, decisions to perform surgery are not straightforward in these patients.…”

Section: Treatment Alternatives Of Obmentioning

confidence: 91%

“…Surgical relief of BOO obviously results in a recovery of normal detrusor behaviour in these patients [Cumming and Chisholm, 1992;Chapple and Smith, 1994]. In other subjects, a CNS disease or Fig.…”

Section: Development Of Obmentioning

confidence: 98%

BPH with coexisting overactive bladder dysfunction—an everyday urological dilemma

Knutson

Edlund

Fall

et al. 2001

Neurourology and Urodynamics

105

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The aim of this study was to use a systematic schedule, including urodynamics, to describe the rate of coexisting overactive bladder (OB) in patients with bladder outlet obstruction (BOO) caused by benign prostatic hyperplasia (BPH). We also identified differences between the patients with pure BOO compared with those with BOO combined with OB (BOO + OB). One hundred and sixty-two men referred to our clinic due to LUTS were included. Patients with a history that might affect their bladder function were excluded. After cystometry and pressure-flow studies, the patients were divided into pure BOO and BOO + OB. Of the 162 men, 55% had pure BOO. BOO + OB was found in 45%. Age, s-PSA, voided volume, and obstruction grade differed significantly between the groups. The patients with BOO + OB were older, had a higher s-PSA, voided smaller volumes, and were more obstructed. We found no differences in TRUS-volume, Q-max, IPS score, or PVR. There was a strong association between OB and BOO, the percentage of OB increasing with increased obstruction. TRUS-volume, Q-max, IPS score, and PVR did not predict whether the patients had a combined BOO + OB or not. These findings indicate that BOO is a progressive disease, which in time causes pronounced obstruction and perhaps in itself contributes to the development of OB.

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“…65 A 56% reduction in the number of acetylcholine-positive nerves was demonstrated in bladder biopsies obtained from obstructed compared to nonobstructed men. 66 Counts of nerve profiles confirmed the reduced density of autonomic innervation and not merely a decrease in the concentration of AchE.…”

Section: Denervationmentioning

confidence: 88%

Obstruction-induced alterations within the urinary bladder and their role in the pathophysiology of lower urinary tract symptomatology.

Komninos

Mitsogiannis

2014

CUAJ

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Cite as: Can Urol Assoc J 2014;8(7-8) AbstractBenign prostatic hyperplasia (BPH) is considered a frequent cause of bladder outlet obstruction (BOO) and lower urinary tract symptoms. This review addresses the bladder response to BOO and focuses on the alterations and biochemical adaptability of the bladder wall in the presence of hypoxia. A literature review of published articles has been performed, including both in vivo and in vitro studies on human and animal tissue.

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Changes in Detrusor Innervation with Relief of Outflow Tract Obstruction

Cited by 52 publications

References 16 publications

Focal changes in nerve, muscle and connective tissue in normal and unstable human bladder

Focal changes in nerve, muscle and connective tissue in normal and unstable human bladder

BPH with coexisting overactive bladder dysfunction—an everyday urological dilemma

Obstruction-induced alterations within the urinary bladder and their role in the pathophysiology of lower urinary tract symptomatology.

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