We measured the pore pressure response due to carbon dioxide (CO 2 ) gas bubble nucleation and growth in a Berea sandstone core flooded with an initially subsaturated aqueous solution of CO 2 , in response to a rapid drop in confining stress, under conditions representative of a confined aquifer. A portion of the CO 2 in the Earth's crust, derived from volcanic, magmatic, and biogenic sources, dissolves in groundwater. Sudden reductions in confining stress in the Earth's crust occur due to dilational strain generated by the propagation of seismic Rayleigh and P waves, or aseismic slip in the near field of earthquakes. A drop in confining stress produces a proportional drop in pore fluid pressure. When the pore fluid contains dissolved CO 2 , the pore pressure responds to a drop in confining stress like it does in the dissolved gas-free case, until the pore pressure falls below the bubble pressure. Gas bubble nucleation and diffusive growth in the pore space trigger spontaneous, transient buildup of the pore fluid pressure, and reduction of effective stress. We measured the rate of pore fluid pressure buildup in the 100 s immediately following the confining stress drop, as a function of the saturation with respect to CO 2 at the lowest pore pressure realized during the confining stress drop, using five different CO 2 partial pressures. The rate scales with the saturation with respect to dissolved CO 2 , from 10 kPa/min at 1.25 to 166 kPa/min at 1.8. The net pore pressure rise was as large as 0.7 MPa (100 psi) over 5 h.