Changes in epidermal dielectric properties due to skin cancer across the band 1 to 50 GHz

Mohammed, Beadaa; Naqvi, Syed Akbar Raza; Manoufali, Mohamed; Bialkowski, Konstanty; Abbosh, Amin

doi:10.1109/ausms.2018.8346990

Cited by 17 publications

(8 citation statements)

References 7 publications

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“…For example, Chen et al proposed a capacitive biosensor modified with silica-alumina to detect glucose levels and to provide a continuous monitoring of diabetes [18]. Others have shown that the dielectric properties of cancer tissues changed with increasing water content [19,20], or that dielectric alterations were well correlated with the carcinogenicity of thyroid nodules [21]. Moreover, Lazebnik et al investigated the dielectric permittivity changes in breast tissue when affected by malignancy as compared with healthy breast tissue, using a sensor in the range of 0.5-20 GHz [22].…”

Section: Introductionmentioning

confidence: 99%

A Novel Microwave Resonant Sensor for Measuring Cancer Cell Line Aggressiveness

D’Alvia

Carraro

Peruzzi

et al. 2022

Sensors

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The measurement of biological tissues’ dielectric properties plays a crucial role in determining the state of health, and recent studies have reported microwave biosensing to be an innovative method with great potential in this field. Research has been conducted from the tissue level to the cellular level but, to date, cellular adhesion has never been considered. In addition, conventional systems for diagnosing tumor aggressiveness, such as a biopsy, are rather expensive and invasive. Here, we propose a novel microwave approach for biosensing adherent cancer cells with different malignancy degrees. A circular patch resonator was designed adjusting its structure to a standard Petri dish and a network analyzer was employed. Then, the resonator was realized and used to test two groups of different cancer cell lines, based on various tumor types and aggressiveness: low- and high-aggressive osteosarcoma cell lines (SaOS-2 and 143B, respectively), and low- and high-aggressive breast cancer cell lines (MCF-7 and MDA-MB-231, respectively). The experimental results showed that the sensitivity of the sensor was high, in particular when measuring the resonant frequency. Finally, the sensor showed a good ability to distinguish low-metastatic and high-metastatic cells, paving the way to the development of more complex measurement systems for noninvasive tissue diagnosis.

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Section: Introductionmentioning

confidence: 99%

A Novel Microwave Resonant Sensor for Measuring Cancer Cell Line Aggressiveness

D’Alvia

Carraro

Peruzzi

et al. 2022

Sensors

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“…Considering that the Cole-Cloe coefficients of melanoma are unavailable, we assign electrical properties with regard to frequencies according to B.J. Mohammed's study via interpolation [24] .…”

Section: Skin Cancer Modelingmentioning

confidence: 99%

Sensitivity investigation of open-ended coaxial probe in skin cancer detection

Liu

Huang

et al. 2023

Phys Eng Sci Med

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Dielectric properties (DPs), as a physical property, are widely used in real-time identification of normal or tumor tissue in vivo. Open-ended coaxial probe method is one of the most common modalities in measuring DPs. This technique secures its promising potential in early-stage skin cancer diagnosis for its non-invasive merit. Although various studies have been reported, systematic assessment is lacking to advance to clinical applications. Parameter interactions and detecting limitations remain unclear. In this study, we examine the minimum detectable size of tumor by using a three-layer skin model by simulation. DP changes under different tumor dimension, probe size, skin thickness, and cancer type were discussed. The smallest detecting size of BCC inside the skin is 0.5 mm radius × 0.1 mm; for SCC inside the skin is 1.4 mm × 1.3 mm in radius and height; the smallest distinguishing size of BCC is 0.6 mm × 0.7 mm in radius and height; for SCC is 1.0 mm × 1.0 mm in radius and height; for MM is 0.7 mm × 0.4 mm in radius and height. We also provide a detailed systematic evaluation of the parameters employed in the method for further applications.

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“…Based on this principle, the DP characterization of both healthy and diseased tissues has been a research interest for scientists, primarily to enable the development of microwave diagnostic and therapeutic applications [3,4]. The DPs of many different tissue types, including but not limited to breast, liver and skin, were characterized with the open-ended coaxial probe (OECP) for cancer diagnosis and treatment [3,[5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Open-Ended Coaxial Probe Sensing Depth with Respect to Aperture Size for Dielectric Property Measurement of Heterogeneous Tissues

Aydınalp¹,

Joof²,

Dilman³

et al. 2022

Sensors

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The open-ended coaxial probe (OECP) method is frequently used for the microwave dielectric property (DP) characterization of high permittivity and conductivity materials due to inherent advantages including minimal sample preparation requirements and broadband measurement capabilities. However, the OECP method is known to suffer from high measurement error. One well-known contributor to the high error rates is tissue heterogeneity, which can potentially be managed through the selection of a probe with a proper sensing depth (SD). The SD of the OECP is dependent on many factors including sample DPs and probe aperture diameter. Although the effects of sample DPs on SD have been investigated to some extent in the literature, the probe aperture diameters, particularly small diameters, have not been fully explored. To this end, the SDs of probes with three different apertures (0.5, 0.9 and 2.2 mm-diameters) were analyzed in this study. Probes’ SDs were first investigated with simulations using a double-layered sample configuration (skin tissue and olive oil). Next, experiments were performed using a commercial OECP with a 2.2 mm aperture diameter. The SD was categorized based on 5%, 20% and 80% DP change. Among these threshold values, a 5% DP change was selected as the benchmark for SD categorization. The findings suggest that probes with a smaller aperture size and correspondingly smaller SD should be utilized when measuring the DPs of thin and multilayered samples, such as healthy and diseased skin tissues, to increase the measurement accuracy.

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Changes in epidermal dielectric properties due to skin cancer across the band 1 to 50 GHz

Cited by 17 publications

References 7 publications

A Novel Microwave Resonant Sensor for Measuring Cancer Cell Line Aggressiveness

A Novel Microwave Resonant Sensor for Measuring Cancer Cell Line Aggressiveness

Sensitivity investigation of open-ended coaxial probe in skin cancer detection

Characterization of Open-Ended Coaxial Probe Sensing Depth with Respect to Aperture Size for Dielectric Property Measurement of Heterogeneous Tissues

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