Changes in erythrocyte polyunsaturated fatty acids and plasma eicosanoids level in patients with asthma

Zhou, Jing; Chen, Lifang; Liu, Zhenjie; Sang, Ling; Li, Yimin; Yuan, Dongjuan

doi:10.1186/s12944-018-0853-y

Cited by 11 publications

(8 citation statements)

References 28 publications

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“…Contrary to our hypothesis there was no difference in O3I, subjects with asthma had a better fatty acid profile, with lower saturated fatty acids, higher monounsaturated and n-3 fatty acids and a lower n-6 PUFA to n-3 PUFA ratio. This is in contrast to the results of Zhou et al [38], who found that subjects in China with asthma had a fatty acid profile composed mostly of SFAs, while those without asthma contained more PUFAs. Similar to our study, supplement and dietary intake data were not available to determine whether these differences were reflective of different dietary or supplement patterns or an effect of asthma.…”

Section: Discussioncontrasting

confidence: 99%

Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

et al. 2019

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Asthma is a chronic inflammatory airway disease, associated with systemic inflammation. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have established anti-inflammatory effects, thus having potential as an adjunct therapy in asthma. This study aimed to compare erythrocyte n-3 PUFA in adults with (n = 255) and without (n = 137) asthma and determine the relationship between erythrocyte n-3 PUFA and clinical asthma outcomes. Subjects had blood collected, lung function measured and Juniper Asthma Control Questionnaire (ACQ) score calculated. Fatty acids were measured in erythrocyte membranes by gas chromatography, and the omega-3 index (O3I) was calculated (% eicosapentaenoic acid + % docosahexaenoic acid). O3I was similar in subjects with and without asthma (p = 0.089). A higher O3I was observed in subjects with controlled or partially controlled asthma (ACQ < 1.5) compared to subjects with uncontrolled asthma (ACQ ≥ 1.5) (6.0% (5.4–7.2) versus 5.6% (4.6–6.4) p = 0.033). Subjects with a high O3I (≥8%) had a lower maintenance dose of inhaled corticosteroids (ICS) compared to those with a low O3I (<8%) (1000 μg (400–1000) versus 1000 μg (500–2000) p = 0.019). This study demonstrates that a higher O3I is associated with better asthma control and with lower ICS dose, suggesting that a higher erythrocyte n-3 PUFA level may have a role in asthma management.

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Section: Discussioncontrasting

confidence: 99%

Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

et al. 2019

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“…Oxylipins are important lipid mediators that are formed from polyunsaturated fatty acids (PUFAs) such as arachidonic acid (ARA), linoleic acid (LA), α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) [1][2][3] in reactions catalyzed by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP 450) enzymes, and non-enzymatic oxidation pathways [1,2]. Oxylipins are involved in various biological processes but, primarily, are important for the regulation of inflammation [4][5][6][7][8]. The direction of oxylipins influence on inflammation depends on their PUFA precursor, usually n-3 PUFA derived oxylipins are anti-inflammatory and pro-resolving [1], while n-6 PUFA metabolites can promote inflammation [1,3].…”

Section: Introductionmentioning

confidence: 99%

Methods of the Analysis of Oxylipins in Biological Samples

et al. 2020

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Oxylipins are derivatives of polyunsaturated fatty acids and due to their important and diverse functions in the body, they have become a popular subject of studies. The main challenge for researchers is their low stability and often very low concentration in samples. Therefore, in recent years there have been developments in the extraction and analysis methods of oxylipins. New approaches in extraction methods were described in our previous review. In turn, the old analysis methods have been replaced by new approaches based on mass spectrometry (MS) coupled with liquid chromatography (LC) and gas chromatography (GC), and the best of these methods allow hundreds of oxylipins to be quantitatively identified. This review presents comparative and comprehensive information on the progress of various methods used by various authors to achieve the best results in the analysis of oxylipins in biological samples.

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“…The pathway by which n-6 PUFA affects glucose levels and diabetes risk is not well-characterized but it is commonly linked to high adiposity and circulating proinflammatory eicosanoids. Indeed, circulating levels of n-6 PUFA have been associated with an increased BMI across the lifespan [37, 38] and elevated levels of proinflammatory eicosanoids in unhealthy and healthy humans [39, 40]. Recently, two independent MR studies, one using the UK Biobank (13,982 T2D cases and 273,412 controls) and the other using both the Wellcome Trust Case Control Consortium and an Australian adult and adolescent cohort (22,669 T2D cases and 58,119 controls) confirmed a causative association between an elevated BMI and the risk of T2D, i.e., OR = 1.37 (95% CI 1.12–1.68) per kilogram/square meter increase or OR = 1.47 (95% CI 1.17–1.85) per 5-kg increase [41, 42].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Causal Association between Long-Chain n-6 Polyunsaturated Fatty Acid Synthesis and the Risk of Type 2 Diabetes: A Mendelian Randomization Analysis

2020

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Background: Globally, 1 in 11 adults has diabetes mellitus, and most of these cases are type 2 diabetes (T2D). The risk of T2D is influenced by many factors, including diet. The synthesis of long-chain n-6 polyunsaturated fatty acids (LC n-6 PUFA) has been posited as a risk factor for T2D; however, its causal role is uncertain. Aim: To test the causal effect of LC n-6 PUFA synthesis on insulin resistance and transgenerational T2D risk in a large cohort of men and women. Methods: Two-sample mendelian randomization (MR) was conducted to evaluate the effect of low or high levels of LC n-6 PUFA synthesis on glycemia and development of T2D in the UK Biobank (n = 463,010) and Meta-Analysis of Glucose-and Insulin-Related Traits Consortium (MAGIC; n = 5,130) cohorts. The increased likelihood of a predisposition to low or high LC n-6 PUFA synthesis and the risk of T2D was also investigated using the participants' siblings and parents. In MR-Base, 4 genetic variants associated with LC n-6 PUFA synthesis were found (p < 10-8). After pruning, 1 variant (rs174547) on the FADS1 gene was retained. Results: Lower LC n-6 PUFA synthesis and abundance (per % unit decrease) are associated with small reductions in the insulin disposition index (-0.038 ± 0.012 mM-1 ; p = 0.002) within MAGIC. In the UK Biobank, we report negligible effects of low n-6 PUFA synthesis on the odds of T2D (OR < 1%; p < 0.05). Additionally, reduced LC n-6 PUFA synthesis does not appear to be a contributor to familial T2D risk. No significant association was observed between LC n-6 PUFA synthesis and BMI. Conclusion: In a primarily white European population, LC n-6 PUFA synthesis is not a major contributor to T2D risk.

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Changes in erythrocyte polyunsaturated fatty acids and plasma eicosanoids level in patients with asthma

Cited by 11 publications

References 28 publications

Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

Methods of the Analysis of Oxylipins in Biological Samples

Investigation of the Causal Association between Long-Chain n-6 Polyunsaturated Fatty Acid Synthesis and the Risk of Type 2 Diabetes: A Mendelian Randomization Analysis

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