Changes in Feeding Behavior After Peripheral Loperamide Administration in Rats

Chumakova, Yu. A.; Bashkatova, Valentina; Sudakov, S. K.

doi:10.1007/s10517-011-1151-0

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…The decrease in food intake has been documented in just a few other studies. 32,33 while the water intake result has been found in several studies. 32,34,35 The number of fecal pellets as well as water and mineral content significantly decreased under LOP injection.…”

Section: Discussionmentioning

confidence: 77%

Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal‐physiological function and against loperamide‐induced constipation coupled to oxidative stress and inflammation in rats

Hajji

Wannes

Jabri

et al. 2020

Neurogastroenterology Motil

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Background Chronic constipation is a gastrointestinal functional disorder which affects patient quality of life. Therefore, many studies were oriented to search herbal laxative agents. In this study, we investigated the effect of Globularia alypum L. leaves aqueous extract (GAAE) against loperamide (LOP)‐produced constipation. Methods Animals were given LOP (3 mg/kg, b.w., i.p.) and GAAE (100, 200, and 400 mg/kg, b.w., p.o.) or yohimbine (2 mg/kg, b.w., i.p.), simultaneously, for 1 week. Gastric‐emptying test and intestinal transit were determined. Colon histology was examined, and oxidative status was evaluated using biochemical‐colorimetric methods. Key Results GAAE ameliorates significantly gastric emptying (64% to 76.5%) and intestinal transit (66.65% to 84.73%). LOP negatively influenced defecation parameters and generated a stress situation. GAAE administration in contrast ameliorated those parameters and re‐established oxidative balance. Conclusion GAAE showed a modest action against oxidative stress and decreased LOP effect and thereby can be considered a pharmacological agent in constipation.

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Section: Discussionmentioning

confidence: 77%

Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal‐physiological function and against loperamide‐induced constipation coupled to oxidative stress and inflammation in rats

Hajji

Wannes

Jabri

et al. 2020

Neurogastroenterology Motil

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“…One day prior to training, animals were subjected to 24-h food deprivation. Deprivation was carried out to speed up the training process, as we showed earlier (Chumakova et al, 2011;Sudakov et al, 2015). Training was performed in the tool chamber equipped with feeder, lever, and light stimulus.…”

Section: Trainingmentioning

confidence: 99%

Involvement of Peripheral Opioid Receptors in the Realization of Food Motivation Into Eating Behavior

Sudakov

Bogdanova

2021

Front. Behav. Neurosci.

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The involvement of peripheral opioid receptors in the mechanisms of eating behavior is still unclear. The aim of this work was to study the role of peripheral, predominantly gastric mu and delta opioid receptors in the realization of food motivation in conditions of different energy costs for eating behavior. Experiments were performed under a between-sessions progressive ratio schedule of reinforcement in food-deprived rats. The level of food motivation was calculated using a self-developed method. Food intake, motor activity, and metabolic rate were recorded in fed and hungry animals. Results showed that intragastric administration of the mu opioid receptor agonist DAMGO led to an increase in the level of food motivation in the light variant of operant feeding behaviors. Food consumption did not change. At high costs for feeding behavior, the administration of DAMGO did not alter food motivation; however, food consumption and motor activity were reduced. Intragastric administration of the delta opioid receptor agonist DADLE did not lead to changes in the level of food motivation and physical activity, but inhibition of feeding behavior was observed in all reinforcement schedules. Three regulatory pathways of eating behavior in difficult food conditions by peripheral, predominantly gastric opioid receptors are hypothesized: environmental-inhibitory afferentations and suppression of the realization of food motivation into behavior; homeostatic-inhibitory action on food motivation; and rewarding-suppression of the anticipatory reinforcement.

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“…We proposed and substantiated a hypothesis on reciprocal interaction between the central and peripheral compartments of the endogenous opioid system [4] implying the involvement of the peripheral opioid system in the mechanisms of sensory satisfaction [2,6]. Vagal afferentation transmits information on activation of μ-opioid receptors (OR) into CNS, which is followed by suppression of the central endogenous opioid system.…”

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confidence: 97%

Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats

2015

Self Cite

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We studied the effect of intragastric administration of peptide agonists of μ-opioid receptors (DAMGO) and δ-opioid receptors (DADLE) on food consumption and food motivation during operant feeding behavior of different intensity and effectiveness. To obtain one food granule, trained rats should press a lever 1 time (day 1), 2 times (day 2), 4 times (day 3), 8 times (day 4), 16 times (day 5), or 32 times (day 6). Activation of δ-opioid receptors in the stomach was followed by suppression of feeding behavior at low energy expenditure. The level of food motivation under these conditions practically did not differ from the control. Activation of μ-opioid receptors in the stomach suppressed energy-consuming feeding behavior, which was accompanied by an increase in the level of food motivation. It can be hypothesized that protein metabolites exhibiting μ-opioid activity probably provide afferent signals into CNS via the vagus nerve to terminate energy expenditure under adverse conditions (although food motivation is not satisfied). Food motivation under these conditions probably contributes to the behavior aimed towards the search for more available food.

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Changes in Feeding Behavior After Peripheral Loperamide Administration in Rats

Cited by 9 publications

References 10 publications

Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal‐physiological function and against loperamide‐induced constipation coupled to oxidative stress and inflammation in rats

Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal‐physiological function and against loperamide‐induced constipation coupled to oxidative stress and inflammation in rats

Involvement of Peripheral Opioid Receptors in the Realization of Food Motivation Into Eating Behavior

Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats

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