Involvement of Peripheral Opioid Receptors in the Realization of Food Motivation Into Eating Behavior

Sudakov, S. K.; Bogdanova, N. G.

doi:10.3389/fnbeh.2020.600920

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…There are other regulatory mechanisms such as the endocannabinoid system [ 81 ] and endogenous opioid [ 82 ]; however, they will not be considered further in the present work.…”

Section: The Hunger–satiety Pathwaysmentioning

confidence: 99%

Could Naringenin Participate as a Regulator of Obesity and Satiety?

et al. 2023

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Obesity is a serious health problem worldwide, since it is associated with multiple metabolic disorders and complications such as cardiovascular disease, type 2 diabetes, fatty liver disease and overall metabolic dysfunction. Dysregulation of the hunger–satiety pathway, which includes alterations of central and peripheral signaling, explains some forms of obesity by favoring hyperphagia and weight gain. The present work comprehensively summarizes the mechanisms by which naringenin (NAR), a predominant flavanone in citrus fruits, could modulate the main pathways associated with the development of obesity and some of its comorbidities, such as oxidative stress (OS), inflammation, insulin resistance (IR) and dyslipidemia, as well as the role of NAR in modulating the secretion of enterohormones of the satiety pathway and its possible antiobesogenic effect. The results of multiple in vitro and in vivo studies have shown that NAR has various potentially modulatory biological effects against obesity by countering IR, inflammation, OS, macrophage infiltration, dyslipidemia, hepatic steatosis, and adipose deposition. Likewise, NAR is capable of modulating peptides or peripheral hormones directly associated with the hunger–satiety pathway, such as ghrelin, cholecystokinin, insulin, adiponectin and leptin. The evidence supports the use of NAR as a promising alternative to prevent overweight and obesity.

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“…There are other regulatory mechanisms such as the endocannabinoid system [ 81 ] and endogenous opioid [ 82 ]; however, they will not be considered further in the present work.…”

Section: The Hunger–satiety Pathwaysmentioning

confidence: 99%

Could Naringenin Participate as a Regulator of Obesity and Satiety?

et al. 2023

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Mitragynine and morphine produce dose-dependent bimodal action on food but not water intake in rats

Zuarth Gonzalez,

Mottinelli,

McCurdy

et al. 2024

American Journal of Physiology-Regulatory, Integrative and Comp

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This study reveals that morphine and the kratom alkaloid mitragynine produce dose-dependent effects on feeding in rats. Low doses stimulate food intake via opioid pathways, while high doses decrease consumption through nonopioid mechanisms. Morphine potently suppresses water intake at all doses, whereas only high doses of mitragynine reduce drinking. These findings provide novel insights into the complex opioid and nonopioid mechanisms underlying the effects of mitragynine on ingestive behaviors.

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Peripherally Restricted Activation of Opioid Receptors Influences Anxiety-Related Behaviour and Alters Brain Gene Expression in a Sex-Specific Manner

Parkar,

Young,

Olson

et al. 2024

IJMS

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Although effects of stress-induced anxiety on the gastrointestinal tract and enteric nervous system (ENS) are well studied, how ENS dysfunction impacts behaviour is not well understood. We investigated whether ENS modulation alters anxiety-related behaviour in rats. We used loperamide, a potent μ-opioid receptor agonist that does not cross the blood–brain barrier, to manipulate ENS function and assess changes in behaviour, gut and brain gene expression, and microbiota profile. Sprague Dawley (male/female) rats were acutely dosed with loperamide (subcutaneous) or control solution, and their behavioural phenotype was examined using open field and elevated plus maze tests. Gene expression in the proximal colon, prefrontal cortex, hippocampus, and amygdala was assessed by RNA-seq and caecal microbiota composition determined by shotgun metagenome sequencing. In female rats, loperamide treatment decreased distance moved and frequency of supported rearing, indicating decreased exploratory behaviour and increased anxiety, which was associated with altered hippocampal gene expression. Loperamide altered proximal colon gene expression and microbiome composition in both male and female rats. Our results demonstrate the importance of the ENS for communication between gut and brain for normo-anxious states in female rats and implicate corticotropin-releasing hormone and gamma-aminobutyric acid gene signalling pathways in the hippocampus. This study also sheds light on sexually dimorphic communication between the gut and the brain. Microbiome and colonic gene expression changes likely reflect localised effects of loperamide related to gut dysmotility. These results suggest possible ENS pharmacological targets to alter gut to brain signalling for modulating mood.

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Involvement of Peripheral Opioid Receptors in the Realization of Food Motivation Into Eating Behavior

Cited by 3 publications

References 44 publications

Could Naringenin Participate as a Regulator of Obesity and Satiety?

Could Naringenin Participate as a Regulator of Obesity and Satiety?

Mitragynine and morphine produce dose-dependent bimodal action on food but not water intake in rats

Peripherally Restricted Activation of Opioid Receptors Influences Anxiety-Related Behaviour and Alters Brain Gene Expression in a Sex-Specific Manner

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