Changes in glucose utilization during development of the lamb

Jarrett, I. G.; Jones, G. B.; Bj, Potter

doi:10.1042/bj0900189

Cited by 37 publications

(11 citation statements)

References 16 publications

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“…The mean hepatic glucose output of 0-20 mmol min-' (100 g)-1 in the newborn is almost equal to the rate of disappearance of glucose in the exteriorized immature fetal lamb (Alexander, Britton & Nixon, 1966). The glucose requirement of the newborn lamb has been estimated to be about 0-028 mmol min-1 kg-1 (Jarret, Jones & Potter, 1964). Thus the liver glucose released through glycogenolysis, as measured at birth, would be sufficient in the short term to provide for the newborn's glucose needs.…”

Section: Discussionmentioning

confidence: 98%

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Blood flow to and the metabolism of glucose and lactate by the liver in vivo in fetal, newborn and adult sheep.

Apatu

Barnes

1991

The Journal of Physiology

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1. The blood flow to the liver in fetuses near to term, in newborn and in adult sheep was measured in vivo by the Fick principle using radionuclide‐labelled plastic microspheres and timed withdrawal of reference organ blood samples. 2. There is a rapid flow of blood, 410.1 +/‐ 41.8 ml min‐1 (100 g liver)‐1, mean +/‐ S.E.M., to the liver in the fetus. Immediately after birth the blood flow is significantly less (172.5 +/‐ 27.5 ml min‐1 (100 g liver)‐1), reflecting the loss of the umbilical venous return to the liver following delivery and separation from the placenta. Arterial blood flow to the liver per unit weight of liver was small in the fetus (9.5 +/‐ 1.2 ml min‐1 (100 g liver)‐1), significantly greater in the immediate newborn (27.9 +/‐ 7.9 ml min‐1 (100 g)‐1) but appeared to decline with age after birth to 12.2 +/‐ 6.6 ml min‐1 (100 g)‐1 in lambs at 16 weeks of age. Portal blood flow to the liver, on a weight basis, changed little with age being 126 +/‐ 20.9 ml min‐1 (100 g liver)‐1 in the fetus, 144.7 +/‐ 21.1 ml min‐1 (100 g liver)‐1 in the immediate newborn and 203.2 +/‐ 27.8 ml min‐1 (100 g liver)‐1 in the adult. 3. Oxygen consumption and glucose and lactate fluxes across the sheep liver were determined from 132 days of gestation into adulthood. 4. The oxygen consumption by the fetal liver was 0.11 +/‐ 0.02 mmol min‐1 (100 g)‐1 which represents about 6% of the total fetal oxygen metabolism. Immediately after birth there was an apparent increase in liver oxygen consumption but the wide variation in the values recorded means that the change is not statistically significant. There were no significant changes in liver oxygen consumption with age after delivery, oxygen consumption by the adult liver was 0.16 +/‐ 0.05 mmol min‐1 (100 g)‐1. 5. The liver at all ages studied consumed lactate. Lactate consumption was particularly high in the fetus (0.13 +/‐ 0.04 mmol min‐1 (100 g)‐1 and could account for three times the oxygen consumed by the fetal liver, but the fate of this lactate is not yet known. 6. In the fetus the liver is in approximately zero glucose balance; in contrast postnatal animals release glucose from the liver at rest.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: Discussionmentioning

confidence: 98%

“…The glucose requirement of the newborn lamb has been estimated to be about 0-028 mmol min-1 kg-1 (Jarret, Jones & Potter, 1964). Thus the liver glucose released through glycogenolysis, as measured at birth, would be sufficient in the short term to provide for the newborn's glucose needs.…”

Section: Discussionmentioning

confidence: 99%

Blood flow to and the metabolism of glucose and lactate by the liver in vivo in fetal, newborn and adult sheep.

Apatu

Barnes

1991

The Journal of Physiology

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“…The postsurgical stress response in preterm humans 28 and lambs 29 involves plasma glucose surges that parallel plasma cortisol levels and broadly reflect surgical trauma. 27 These factors prevailed against attempts to maintain normoglycaemia and so the objective re-focused on ensuring that the lambs periodically drank milk, with a rationale that this would promote sucking and ewe-lamb bonding, while providing glucose in the animals that were hypoglycaemic. Consequently, bottled ewes' milk, or milk replacer (approximately 180 mL) was provided at 3 h intervals to lambs which were not allowed or unable to suckle.…”

Section: Discussionmentioning

confidence: 99%

The perioperative care of lambs and ewes when the former undergo major experimental (scoliotic) surgery

Clutton

Vettoratto²,

Schoeffman

et al. 2013

Lab Anim

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The purpose of the study was to optimize postoperative comfort in lambs anaesthetized for the surgical creation of scoliosis while maintaining the ewe-lamb relationship to miminize rejection rates. The first management plan produced six scoliotic lambs but intraoperative hypoventilation and hypovolaemia followed by postoperative dyspnoea, pain, monitoring and nursing difficulties, hypothermia, hypoglycaemia and tympany were encountered. Three of eight lambs (38%) were rejected by their ewes. Perioperative management was amended which, combined with improved surgical technique, produced 16 scoliotic lambs. The lambs recovered more rapidly (mean time to standing after discontinuation of anaesthesia was reduced from 12 h to 70 min) and appeared to be more comfortable. No rejections occurred after the refinements were implemented.

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“…For the comparison of the values which have been reported by previous workers in sheep, the entry rate was also measured by the method of primed continuous infusion of glucose-V- (Table II), and the entry rate was shown to decrease with age as previously reported by Jarrett et a[. 31 The value of glucose entry rate in adult (2.4 mg/ kg body wt. per min) was also close to that (80 g/day/kg, i.e.…”

Section: Ldimentioning

confidence: 99%

Changes in the Rates of Recycling and Turnover of Glucose during Development of Sheep

Muramatsu

Sugawara

Sasaki

et al. 1974

Agricultural and Biological Chemistry

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Changes in glucose utilization during development of the lamb

Cited by 37 publications

References 16 publications

Blood flow to and the metabolism of glucose and lactate by the liver in vivo in fetal, newborn and adult sheep.

Blood flow to and the metabolism of glucose and lactate by the liver in vivo in fetal, newborn and adult sheep.

The perioperative care of lambs and ewes when the former undergo major experimental (scoliotic) surgery

Changes in the Rates of Recycling and Turnover of Glucose during Development of Sheep

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