Changes in health-related quality of life and working competence before and after liver transplantation

Shih, Frank Y.; Hu, Rey‐Heng; Ho, Ming‐Chih; Lin, Hung-Ru; Lin, Meng-Chun; Lee, Po‐Huang

doi:10.1016/s0041-1345(00)01610-9

Cited by 20 publications

(9 citation statements)

References 24 publications

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“…In this study of 60 consecutive patients activated for liver transplantation, HRQoL generally improves following transplantation, but not to the same degree in all patients and, in some patients, it can even decline. Similar results have been observed by other investigators (10, 12–14).…”

Section: Discussionsupporting

confidence: 93%

Factors influencing change in health‐related quality of life after liver transplantation

Estraviz

Quintana

Valdivieso

et al. 2007

Clinical Transplantation

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Health-related quality of life is influenced by the severity and etiology of cirrhosis-patients with Child class C and those with alcoholic or viral cirrhosis have the poorest quality of life. There were no differences observed among the groups after the transplantation, as the patients with the lowest HRQoLs prior to surgery demonstrated greater gains in HRQoL associated with liver transplantation.

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Section: Discussionsupporting

confidence: 93%

Factors influencing change in health‐related quality of life after liver transplantation

Estraviz

Quintana

Valdivieso

et al. 2007

Clinical Transplantation

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show abstract

“…In addition, as they recover from their liver transplantation procedures, many patients report significant improvements in QOL, and some are able to return to work. Interestingly, despite differences in culture and race/ethnicity that would be expected to influence work patterns and perceptions of QOL, these findings have been found among transplant recipients from Japan, 18 Taiwan, 19 Sweden, 20 and the United States. 4,5 Further research that provides detailed descriptions of the groups of patients for whom QOL is not improved and return to satisfying employment is not possible is needed.…”

Section: Discussionmentioning

confidence: 82%

Quality of life and employment after liver transplantation

Bravata

Keeffe

2001

Liver Transplantation

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Key Points 1. In general, the health-related quality of life (QOL) of transplant recipients is impaired before and improves after liver transplantation. 2. Transplant recipients report largest gains in those aspects of QOL most affected by physical health and smaller improvements in areas affected by psychological functioning. 3. No utility-based measures have been used with liver transplant recipients; therefore, the necessary QOL weights for use in cost-effectiveness evaluations of liver transplantation are lacking. 4. Pretransplantation, the percentage of candidates with alcoholic liver disease (ALD) who work is less than that of candidates without ALD. However, there is no difference in rates of employment posttransplantation. 5. No study has described types of wages and benefits associated with jobs before or after transplantation or the extent to which health insurance benefits associated with employment motivate changes in work status. 6. Many studies in this field used nonvalidated heterogeneous instruments to measure QOL and employment, thus limiting the opportunity to combine results across studies and compare outcomes for liver transplant recipients with other patient populations. (Liver Transpl 2001; 7:S119-S123.) C hronic liver disease and its complications are the ninth leading cause of death in the United States. In addition to its effect on mortality, end-stage liver disease has a profoundly negative impact on functional status outcomes. Patients with liver failure experience various degrees of hepatic encephalopathy, with reduced cognitive function as a result of toxic metabolites that are not cleared by the failing liver and cross the blood-brain barrier. 1 Other clinical manifestations of patients with hepatic encephalopathy include lability of affect, atypical emotional responses, depression, and anxiety. 2 Given that this psychological and intellectual deterioration occurs concomitantly with the physical deterioration associated with liver failure, it is not surprising that patients with end-stage liver disease should have significant impairment of quality of life (QOL), often associated with loss of employment.Liver transplantation is widely accepted as treatment for end-stage liver disease. Currently, more than 85% of adult liver transplant recipients survive the first year after transplantation, and 55% survive more than 9 years. 3 As clinical outcomes of liver transplantation improve, outcomes relating to transplant recipients' overall functional status and QOL become increasingly important targets for evaluation. We recently performed a comprehensive meta-analysis of patients' QOL and employment after liver transplantation from 89 studies that reported on 6,306 patients. [4][5][6] We sought to characterize the overall effect of liver transplantation on various aspects of QOL and describe long-term patterns of employment. Since the publication of this work, several important studies have been published on this topic. In this report, we describe primary results of the meta-analysis and di...

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“…Nevertheless, extensive data on the well being of patients listed for a liver transplantation are currently not available. Levels of health-related quality of life (HRQoL) are known to be lower before liver transplantation compared to after [4][5][6][7][8][9][10][11], but there is little knowledge of the influence of psychological variables on the experienced HRQoL of these patients. Levels of anxiety and depression have been reported to be elevated in different transplant patient populations, including patients with liver disease [11].…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life and psychological correlates in patients listed for liver transplantation

et al. 2007

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Changes in health-related quality of life and working competence before and after liver transplantation

Cited by 20 publications

References 24 publications

Factors influencing change in health‐related quality of life after liver transplantation

Factors influencing change in health‐related quality of life after liver transplantation

Quality of life and employment after liver transplantation

Health-related quality of life and psychological correlates in patients listed for liver transplantation

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