Objective
End stage liver disease is associated with diminished quality of
life. Numerous physical and psychosocial problems that impact quality of
life are common in those undergoing evaluation for liver transplantation.
Identifying which of these challenges are most closely associated with
quality of life would be helpful in developing priority targets for
evidence-based interventions specific to those undergoing transplant
evaluation.
Method
108 adults undergoing psychological assessment for liver transplant
completed clinical interview, neuropsychological testing, and self-report
inventories of depression, anxiety, cognitive appraisal characteristics,
support resources, and quality of life.
Results
Multiple regression analyses revealed that while emotional symptoms
(anxiety and depression) were primarily associated with mental quality of
life, illness apprehension was the only variable uniquely associated with
physical quality of life after accounting for severity of liver disease,
cognitive status, emotional symptoms, and support resources.
Conclusion
Findings suggest that psychosocial interventions prioritizing
reduction of illness related fear and symptoms of anxiety/depression will
likely have the greatest impact on quality of life in persons with end stage
liver disease awaiting transplantation.