Changes in immediate visual memory predict cognitive impairment

Zonderman, Alan B.; Giambra, Leonard M.; Arenberg, David; Resnick, Susan M.; Costa, Paul T.; Kawas, Claudia H.

doi:10.1093/arclin/10.2.111

Cited by 73 publications

(32 citation statements)

References 27 publications

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“…The majority of BLSA participants are white; work in or are retired from scientific, professional, or managerial positions; graduated from high school or college; and married. 19,20 Beginning in 1986, neuropsychological tests were administered to all subjects aged 60 years or older. For the current study, subjects were selected from BLSA participants evaluated from July 1986 to December 1995.…”

Section: Methodsmentioning

confidence: 99%

Systolic Blood Pressure within an Intermediate Range May Reduce Memory Loss in an Elderly Hypertensive Cohort

Sacktor

Gray

Kawas

et al. 1999

J Geriatr Psychiatry Neurol

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The objective of this study was to determine if maintenance of systolic blood pressure (BP) within a high range or low range among treated hypertensive patients increases the risk of memory decline. Biennial neuropsychological evaluations were performed on 158 hypertensive subjects. Decline/year was measured on the Cued Selective Reminding test (total free recall and delayed recall) in three systolic BP groups (low-i.e., mean systolic BP during the follow-up period < 135 mm Hg; intermediate-i.e., 135 mm Hg < or = mean systolic BP < or = 150 mm Hg; high-i.e., mean systolic BP > 150 mm Hg). In total free recall, the three systolic BP groups had significantly different declines per year (P = .02), with patients in the high subgroup showing the greatest decline. In delayed recall, the three systolic BP groups also showed significantly different declines per year (P = .04), with patients in the low subgroup having the greatest decline. Chronically elevated systolic BP > 150 mm Hg is associated with accelerated memory decline compared to older treated hypertensive patients with systolic BP in an intermediate range. Chronically maintained systolic BP within a low normal range < 135 mm Hg in older treated hypertensive subjects may be associated with accelerated memory decline, specifically in a test of delayed memory recall, compared to patients with systolic BP in an intermediate range. Optimal regulation of systolic BP may be a potential modifiable risk factor to prevent or minimize memory loss in older hypertensive patients.

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Section: Methodsmentioning

confidence: 99%

Systolic Blood Pressure within an Intermediate Range May Reduce Memory Loss in an Elderly Hypertensive Cohort

Sacktor

Gray

Kawas

et al. 1999

J Geriatr Psychiatry Neurol

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“…These subjects visit the National Institute on Aging at regular intervals for two days of medical, physiological and psychological testing. Examples of measurements taken include electrocardiograms, memory tests, glomerular filtration rates and various serum metabolite levels [36][37][38][39]. Currently, the study population has 1450 active participants, aged 18-97 years (http://www.grc.nia.nih.gov/branches/blsa/ blsa.htm).…”

Section: Longitudinal Studies Of Human Ageingmentioning

confidence: 99%

Genetics and genomics of human ageing

Wheeler

Kim

2011

Phil. Trans. R. Soc. B

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Ageing in humans is typified by the decline of physiological functions in various organs and tissues leading to an increased probability of death. Some individuals delay, escape or survive much of this age-related decline and live past age 100. Studies comparing centenarians to average-aged individuals have found polymorphisms in genes that are associated with long life, including APOE and FOXOA3, which have been replicated many times. However, the associations found in humans account for small percentages of the variance in lifespan and many other gene associations have not been replicated in additional populations. Therefore, ageing is probably a highly polygenic trait. In humans, it is important to also consider differences in age-related decline that occur within and among tissues. Longitudinal data of age-related traits can be used in association studies to test for polymorphisms that predict how an individual will change over time. Transcriptional and genetic association studies of different tissues have revealed common and unique pathways involved in human ageing. Genomic convergence is a method that combines multiple types of functional genomic information such as transcriptional profiling, expression quantitative trait mapping and gene association. The genomic convergence approach has been used to implicate the gene MMP20 in human kidney ageing. New human genetics technologies are continually in development and may lead to additional breakthroughs in human ageing in the near future.

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“…We examined whether 6-year changes in immediate visual memory performance assessed by the Benton Visual Retention Test 6 predicted AD prior to its onset. 2 In these early data, there were 371 BLSA participants, 7 of whom were diagnosed as probable or definite AD. Six-year longitudinal change as well as level of immediate visual memory performance also predicted subsequent cognitive performance 6 to 15 years and 16 to 22 years later, even after adjusting for the influences of age, general ability, and initial immediate memory.…”

Section: Predicting Admentioning

confidence: 99%

Predicting Alzheimer’s Disease in the Baltimore Longitudinal Study of Aging

Zonderman

2005

J Geriatr Psychiatry Neurol

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Longitudinal studies offer opportunities for studying children whose parents have Alzheimer's disease. The Baltimore Longitudinal Study of Aging (BLSA) has examined adult cognitive performance but has not systematically recruited participants' children. We initiated studies of dementia in the 1980s. This work suggested that hormone replacement and use of nonsteroidal anti-inflammatory drugs reduced the risk of Alzheimer's disease and that risk for Alzheimer's disease could be predicted from cognitive performance as many as 20 years prior to its onset. More recently, we showed that premorbid levels of free testosterone were lower in men who developed Alzheimer's disease and premorbid depressive symptomatology was a risk for Alzheimer's disease in men but not women as many as 6 years before the onset of dementia. Participants in the BLSA include family members with a variety of degrees of relationship, but there is no systematic effort to collect data from relatives of participants.

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Changes in immediate visual memory predict cognitive impairment

Abstract: Six-year changes in immediate visual memory performance assessed by the Benton

Cited by 73 publications

References 27 publications

Systolic Blood Pressure within an Intermediate Range May Reduce Memory Loss in an Elderly Hypertensive Cohort

Systolic Blood Pressure within an Intermediate Range May Reduce Memory Loss in an Elderly Hypertensive Cohort

Genetics and genomics of human ageing

Predicting Alzheimer’s Disease in the Baltimore Longitudinal Study of Aging

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