Changes in intraocular pressure and pupil size following intramuscular administration of hydromorphone hydrochloride and acepromazine in clinically normal dogs

Abstract

CDI measurements in Beagles with primary open angle glaucoma during the course of 4 years indicate easily measurable and repeatable progressive blood flow abnormalities before the elevation of IOP and, thereafter, with gradually increased levels of IOP.

The effect of changes in cardiovascular activity on corneal biomechanics and pulsation in rabbits

“…Assuming an average value of natural IOP in rabbits in the range of 15-23 mmHg 14 , it can be claimed that after anesthesia, the mean IOP in Group I might not have changed or slightly decreased, whereas in Group II it might have significantly decreased. Volatile anaesthetics, like isoflurane used in Group I, either slightly reduce or have no effect on IOP 30,31 . Moreover, additionally used midazolam and acepromazine has been shown to have no significant effect on IOP 30 .…”

Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil diameter in dogs

“…In fact, the ascending effect of Acepromazine was dominant compared to the descending effect of Medetomidine at this dose. Tamura et al (2002) and Stephan et al (2003) achieved the same results so that the intramuscular administration of Acepromazinehydromorphone at 0 to 10 and 25 min after injection showed a reduction in the intraocular pressure, but the reduction was not significant. Results of the present study were consistent with the research by Mrazova et al (2018), which intravenously injected a similar dose of Medetomidine (10 µg/kg).…”

Lack of effects of intramuscular medetomidine on intraocular pressure in clinically normal cats

“…The effect of sedatives on IOP may vary between species as different effects have been observed in horses and dogs, 2,9–12 and so species-specific information is important in the selection of sedatives.…”

“…Previous studies in dogs reported that intramuscular administration of acepromazine, chlorpromazine and medetomidine cause no significant changes in IOP values. [2][3][4][5] It is not known whether sedation with intramuscular medetomidine would affect IOP in cats. The purpose of this study was to determine the effects of intramuscular medetomidine on the results of tonometery in healthy cats.…”