Changes in lipid metabolism in women with age-related macular degeneration

Abstract

Age-related macular degeneration (AMD) is one of the leading causes of visual loss among people aged 65 and older. At present the origin of AMD still remains unknown. The objective was to evaluate the chosen lipid and lipoprotein concentrations in blood of patients with AMD. Sixty women aged 55-71 (mean age 65.1+/-5.7) were treated in the outpatient ophthalmological clinic for more than two years because of AMD. We evaluated total serum cholesterol (TCH), triglycerides (TG), HDL-cholesterol (HDL), LDL-cholesterol (LDL), lipoprotein (a) (Lp(a)), apolipoprotein AI (Apo AI) and apolipoprotein B (Apo B) by direct spectrophotometry (Human and Randox standard kits, USA). We found a significant increase of TCH, LDL and TG (224.36+/-41.67 mg/dl, 159.02+/-39.66 mg/dl and 120.92+/-42.64 mg/dl), and a significant decrease of HDL (38.68+/-6.36 mg/dl) in the AMD patients when compared with the control group. We have not found a significant difference in the average TG level between the studied groups. The concentration of Apo B was markedly increased (164.66+/-46.46 mg/dl) and Apo AI concentration was markedly decreased (128.9+/-17.01 mg/dl) in the AMD patients when compared with the control group. There was no significant difference in the concentration of the Lp(a) between the two groups. The results of our present study could point to the fact that changes in the lipid metabolism could be one of the very important risk factors involved in the pathogenesis of AMD.

Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene ( LIPC )

“…Data regarding the association between serum HDL levels and AMD are conflicting (37,(39)(40)(41)(42)(43)(44). Some studies found no relationship (37,43), whereas others found that increased risk of AMD or a subphenotype was associated with increased HDL levels (39,41).…”

“…Some studies found no relationship (37,43), whereas others found that increased risk of AMD or a subphenotype was associated with increased HDL levels (39,41). Three studies have shown an inverse relationship with either decreased HDL levels in AMD cases or decreased incidence of advanced AMD with higher HDL (40,42,44).…”

Role of Lipids in Retinal Vascular and Macular Disorders

“…For example, several studies have not found an association between serum lipid profile and AMD risk [18,20,23]. Elevated HDL but not total cholesterol was associated with an increased risk of AMD in a study by Van Leeuwen et al [18] Non neovascular AMD was unrelated to cholesterol level in a study by Hyman et al [20] No difference in total cholesterol, triglycerides, phospholipids, HDL, LDL concentrations were observed between AMD patients and controls in the study by Abalain et al [23], and there was no significant difference in the concentration of the Lipoprotein(a) between the AMD and control groups in the work by Nowak et al [24].…”

“…To date, epidemiological studies on the association between serum lipid and AMD risk have been inconsistent [18][19][20][21][22][23][24][25][26]. Part of this variability may have resulted from reporting different forms and stages of AMD with different lipid profiles.…”

The age-related macular degeneration as a vascular disease/part of systemic vasculopathy: contributions to its pathogenesis

“…Ha alaposan elemezzük az AMD kockázati tényezőinek tekintett állapotokat (1. táblázat) -ezek közé tartozik az AMD családi halmozódása [24], az öregedés/öregség [25], az AMD-re hajlamosító, komplementtel kapcsolatos genetikai polimorfi zmus [26], a dohányzás [27], az elhízás, illetve a kórosan nagyobb testtömegindex [27], a hypertonia, magasabb szisztolés-diasztolés és átlagos artériás vérnyomás [27], a praeeclampsia [28], a fi brinogén emelkedett szintje [29], a hypercholesterinaemia (emelkedett összes koleszterin) és az étkezés utáni hyperlipaemia [29], koleszterinben dús étrend [30], magas zsírbevitellel járó táplálkozás [31], disznózsír és szilárd zsírok (szilárd növényi olaj) és szilárd zsírral sütött ételek (a szérumkoleszterin-szinttől, illetve testtömegindextől függetlenül) [32], magas LDL-koleszterin-szint [29] (a HDL-koleszterin emelkedett, szívvédő hatásúnak tekintett koncentrációszintje az AMD csökkent kockázatával jár), csökkent HDL-koleszterin [32], a trigliceridek felszaporodása [32], az ApoB emelkedett és az ApoA csök-kent koncentrációja [32], magas oxidált LDL-koleszterin-szint [33], megnőtt ApoA1- [34], magas szérumfi brinogén-szint [27], emelkedett CRP [35], magas interleukin-6 [36], az intracelluláris adhéziós mole- ÖSSZEFOGLALÓ KÖZLEMÉNY kula magas szérumszintje [36,37], emelkedett von Willebrand-faktor [4], magas antifoszfolipidantitest-szint [38], alkoholizmus [39], diabetes mellitus [40,41], ét-kezés utáni hyperglykaemia, illetve nagy glykaemiás indexű táplálék [42], fokozott (szisztémás) AGE-felhalmozódás [43], megnőtt leptin- [44] és csökkent adiponektinszint [44], hypomagnesaemia [45], a cink alacsony szérumszintje [46], metabolikus szindró...…”