Changes in lymphocyte subsets during normal pregnancy

Kühnert, Maritta; Strohmeier, R.; Stegmüller, M.; Halberstadt, E.

doi:10.1016/s0301-2115(97)00180-2

Cited by 117 publications

(84 citation statements)

References 19 publications

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“…It has been well documented that lymphocyte count declines during pregnancy and reaches its normal level after delivery (3,8,9). We have shown a significant decrease in total lymphocyte levels during pregnancy, consistent with the data given in the literature.…”

Section: Discussionsupporting

confidence: 92%

“…Also, Kühner at al. demonstrated enhanced lymphocyte levels in the first week after labour (9). We have shown that lymphocytes decrease after delivery; however, our data is limited to post-partum 1 st day.…”

Section: Discussionmentioning

confidence: 51%

“…Some studies were carried out to execute the distribution of lymphocyte subsets during pregnancy. T and B lymphocytes, NK cells, and T-cell subgroup proportion do not change is the main consensus of these studies (6,9). We did not analyze alteration in the lymphocyte subsets in our study.…”

Section: Discussionmentioning

confidence: 81%

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Total Blood Lymphocyte Count Alteration During and after Pregnancy

Örgül¹,

Soyak²,

Portakal³

et al. 2017

Gynecol Obstet Reprod Med

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OBJECTIVE:To investigate the impact of gestational changes on blood lymphocyte count in healthy pregnancies. STUDY DESIGN:This retrospective study is consisted of 108 consecutive normal pregnancies who delivered at our department in December 2015. High-risk pregnancies with poor neonatal outcome and pregnancies with maternal disorders which may affect lymphocyte counts were excluded from the study. "Complete blood count" results of the patients were obtained from the computerized data base system of Hacettepe University Hospital. Blood samples of patients which were withdrawn a) prior to pregnancy (1-6 months before getting pregnant), b) during pregnancy (11-14 th gestational weeks) and c) post-partum first day were used in this study. RESULTS:The mean blood lymphocyte count was 2049.07 (±758.69) in patients before their pregnancies. The mean lymphocyte count decreased to 1850.93 and 1625 during pregnancy and after delivery respectively. A statistically significant decrease was found between three periods (before, during, and postpartum 1 st day) (p:0.003). CONCLUSION:We have shown a significant decrease in total lymphocyte levels during pregnancy, consistent with the data presented in the literature. Pregnancy and related hormones have a negative impact on total blood lymphocyte level.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 51%

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Total Blood Lymphocyte Count Alteration During and after Pregnancy

Örgül¹,

Soyak²,

Portakal³

et al. 2017

Gynecol Obstet Reprod Med

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“…On the other hand, MDSCs have previously been shown to inhibit NK cytotoxicity in tumor-bearing mice as well as in cancer patients (23)(24)(25). We therefore assessed whether the well-known expansion of granulocytic populations and increased leukocyte counts associated with pregnancy (26) could reflect, at least in part, the accumulation of such immunosuppressive cells. In mice, MDSCs are characterized by coexpression of CD11b and Gr-1 (27).…”

Section: Mdsc Accumulation In Pregnant Mice Contributes To Increased mentioning

confidence: 99%

Myeloid-derived suppressor cells are implicated in regulating permissiveness for tumor metastasis during mouse gestation

Mauti

Bitoux²,

Baumer³

et al. 2011

J. Clin. Invest.

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Metastasis depends on the ability of tumor cells to establish a relationship with the newly seeded tissue that is conducive to their survival and proliferation. However, the factors that render tissues permissive for metastatic tumor growth have yet to be fully elucidated. Breast tumors arising during pregnancy display early metastatic proclivity, raising the possibility that pregnancy may constitute a physiological condition of permissiveness for tumor dissemination. Here we have shown that during murine gestation, metastasis is enhanced regardless of tumor type, and that decreased NK cell activity is responsible for the observed increase in experimental metastasis. Gene expression changes in pregnant mouse lung and liver were shown to be similar to those detected in premetastatic sites and indicative of myeloid cell infiltration. Indeed, myeloid-derived suppressor cells (MDSCs) accumulated in pregnant mice and exerted an inhibitory effect on NK cell activity, providing a candidate mechanism for the enhanced metastatic tumor growth observed in gestant mice. Although the functions of MDSCs are not yet understood in the context of pregnancy, our observations suggest that they may represent a shared mechanism of immune suppression occurring during gestation and tumor growth.

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“…There are increased percentages of HLA-DR+ and CD56+ activated T-cells during the first trimester (16), increased soluble interleukin-2 receptor (sIL-2R) and CD8+ T cell levels (17) and maternal serum factors which down regulate B cell activity (18). Decreased absolute numbers of circulating T helper and NK cells late in pregnancy have also been suggested to play a role in maintenance of healthy gestation (19).…”

Section: Introductionmentioning

confidence: 99%

Trace elements and cell-mediated immunity in gestational and pre-gestational diabetes mellitus at third trimester of pregnancy

Mahmoud¹

2012

AMA

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Objective. The aim of the study: To evaluate the correlations between Zn2+, Cu2+, Mg2+, Se2+ and Cr3+ and alteration in T cell subsets during diabetic and normal pregnancy. Methods. The study involved 63 women with gestational diabetes mellitus (GD) and 16 pregnant women with Type 2 diabetes and 48 healthy, non-pregnant women were included as controls. Ten ml of whole venous blood from each participant was analyzed for electrolytes by atomic absorption; total antioxidant activity, individual enzymatic antioxidants by spectrophotometry; and lymphocyte sub-populations by flow cytometry. Results. There were significant changes in lymphocyte sub-populations: Naïve T cells were decreased and memory T-cells and activated T cells (CD4+HLA-DR+, CD4+CD29+) were increased in diabetes in pregnancy. Zn2+ and Cr3+ deficiency were observed in Type 2 diabetics with an increase in Cu2+ in all pregnant cohorts. In healthy pregnant subjects, CD4+-HLA-DR+ was increased in direct proportion to serum Mg2+ (p<0.05) and Se2+ (p<0.01). In insulin-treated GD patients, CD4+CD29+ cells were increased proportionally to serum Zn2+ (p<0.05) while in diet controlled GD cohort CD45RO+/ CD45RA+ T cells correlated directly with serum Mg (p<0.05) and Zn2+ (p<0.01) while it correlated inversely with serum Cu2+ (p<0.01). Conclusions. The results of the present study show a correlation between trace element deficiency and increased lipid peroxidation in diabetes in pregnancy and lymphocyte activation. Dietary manipulation may, therefore, point to improvement in existing approaches to management of diabetes mellitus in pregnancy.

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Changes in lymphocyte subsets during normal pregnancy

Cited by 117 publications

References 19 publications

Total Blood Lymphocyte Count Alteration During and after Pregnancy

Total Blood Lymphocyte Count Alteration During and after Pregnancy

Myeloid-derived suppressor cells are implicated in regulating permissiveness for tumor metastasis during mouse gestation

Trace elements and cell-mediated immunity in gestational and pre-gestational diabetes mellitus at third trimester of pregnancy

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