Total Blood Lymphocyte Count Alteration During and after Pregnancy

Örgül, Gökçen; Soyak, Burcu; Portakal, Oytun; Beksaç, Meral; Beksaç, Mehmet Sinan

doi:10.21613/gorm.2016.633

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…Some older papers suggest that there was no change overall in lymphocyte count during pregnancy (13,14). Results from more recent studies suggest that there is a decrease in lymphocyte count (15,16), with the biggest decrease occurring in the first and second trimesters (5). The bulk of available literature agrees with the findings of a reduction in overall lymphocyte count; however, a recent study in 2013 found a significant increase in the lymphocyte count of 200 pregnant women (17,18), further complicating the discussion.…”

Section: Discussionmentioning

confidence: 69%

Neutrophil/lymphocyte ratio and Lymphopenia as a severity marker rather than diagnostic marker of Covid-19 in pregnant population, A retrospective case series.

Elhossamy

Korrapati

Cole

et al. 2020

Preprint

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Objective: Recommending using lymphopenia and neutrophil/lymphocyte ratio(NLR) as a severity marker rather than diagnostic marker for pregnant patients with COVID-19. Design: retrospective study. Setting :Birmingham city hospital, Birmingham, United Kingdom maternity unit admissions to delivery suite between 10 March 2020 and 31 May 2020. Population: We reviewed all patients who tested positive for COVID-19 and were pregnant. Methods: We looked at the white blood cell counts of all the patients and their outcomes. We specifically looked at lymphocyte count as well as neutrophil count and calculated the neutrophil lymphocyte ratio(NLR) for every case in our series. Main Outcome Measures: Only 15.3% of pregnant patients who tested positive for COVID-19 had lymphopenia and raised NLR in contrast with up to 90% in non-pregnant population. Results: Our results indicate that out of 13 patients who tested positive, for COVID-19, only 2 915.3% had lymphopenia and raised NLR more than 8. Conclusions: There are very conflicting results for normal values of white blood cells and lymphocytes in pregnancy. In our study Lymphopenia and raised NLR do not seem to be common findings in confirmed pregnant cases of COVID-19 but can help determine morbidity as patients that had lymphopenia and raised NLR displayed severe symptoms, were more unwell and needed high dependency unit admission. Introduction: Coronaviruses can infect humans and animals. A novel Coronavirus was identified in 2019, causing pneumonia in patients within China initially then spread globally, resulting in an epidemic. The virus that causes COVID-19 has been named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (1), (3) Full-genome analysis indicated that the coronavirus that causes COVID-19 is a beta coronavirus that resembles SARS Virus (severe acute respiratory syndrome virus). Similarly, the structure of the receptor-binding gene region is very similar to that of the SARS virus, and the virus has been shown to use the same receptor, the angiotensin-converting enzyme 2 (ACE2), for cell entry (2)

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Section: Discussionmentioning

confidence: 69%

Neutrophil/lymphocyte ratio and Lymphopenia as a severity marker rather than diagnostic marker of Covid-19 in pregnant population, A retrospective case series.

Elhossamy

Korrapati

Cole

et al. 2020

Preprint

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“…Women with iron stores have a smaller increase than those with iron deficiency. This inability to expand plasma volume may disguise a decrease in hemoglobin content in some iron-deficient women (40).…”

Section: Biochemical Alterations Of the Study Populationmentioning

confidence: 99%

Physiological, hematological and some biochemical alterations during pregnancy

Saleem

Muhammed

Al-Hetty

et al. 2022

ijhs

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The mother's body undergoes several changes in all organ of the bodily systems to stimulate the growth and development of the fetus; hence, the clinical laboratory play an important role in the management of pregnant women. A total number of 90 sample were (60 pregnant and 30 control) from the general women population that were referrals from al-Ramadi of obstetrician – gynecologist hospital in the period November 2021 to June 2022. The result of statistical analysis of the present study showed there were no significantly differences between age of pregnant and control group and the gestation period time the pregnant women was 15 % in 1st trimester of gestation, 35 % in 2nd trimester of gestation and 50 % in 3rd trimester of gestation , in addition complete peripheral blood count examination ( leukocytes , Neutrophils , Lymphocytes ,Erythrocytes , Hemoglobin , Hematocrit , and Platelet) revealed significantly lower rates of pregnancy compared to the control group while (Neutrophil) were revealed significantly increase between pregnant and control group.

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