Physiological, hematological and some biochemical alterations during pregnancy

Saleem, Hiba Muwafaq; Muhammed, Thikra Majid; Al-Hetty, Hussein Riyadh Abdul Kareem; Salman, Dina Akeel

doi:10.53730/ijhs.v6ns6.12017

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…Hepcidin exerts its effects its receptor, ferroportin, a cellular iron exporter. Hepcidin is regulated by plasma iron concentrations, body iron stores, infection and inflammation, and erythropoiesis, resulting in systemic iron homeostasis [18,19]. .In contrast, blocking the action of Hepcidin in certain malignancies can suppress the progression of the tumour [20].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for iron metabolic disorders in newly diagnosed B-chronic lymphocytic leukemia patients

Saleem¹,

Awad²,

Alwan³

2022

ijhs

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Due to the importance of increasing the incidence conditions of B cell chronic lymphocytic leukemia (B-CLL) that requiring accurate knowledge of the biology behind the pathogenesis and risks of this disease of each individual patient, this study was designed to investigate if hormonal alterations such as Hepcidin, Erythropoietin, and oxidant-antioxidant status may be useful in the understanding of B-CLL development in addition the relationship of these parameters with anemia in advance clinical stage in newly diagnosed patients with B-CLL. This study was conducted on 60 newly diagnosed patients with B-CLL and 30 control group .The socio-demographic information including (age and sex) and clinical data were collected for the period from 20 February until 25 December 2021. The result of the present study showed that out of the 60 newly diagnosed B-CLL patients, 39 was male and 21 was females, with the mean age ( 64.04 ± 5.6 ) years and out of the 30 controls group ,12 was males and 18 was females with the mean age of ( 63.33 ± 4.70) years .therefore, it was a higher prevalence p value ≤0.05 of newly diagnosed B-CLL patients in males (65.0 %) compare to females (35.0 % ).

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Section: Discussionmentioning

confidence: 99%

Risk factors for iron metabolic disorders in newly diagnosed B-chronic lymphocytic leukemia patients

Saleem¹,

Awad²,

Alwan³

2022

ijhs

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“…Iron determines the supply of adequate amounts of oxygen, electron transport, and the proper functioning of enzymes. It is important for high-metabolic rate cells [ 17 ]. Hematocrit is of particular importance in the assessment of animal physiology.…”

Section: Discussionmentioning

confidence: 99%

“…The analyses showed, for the first time, that the phage cocktail did not disturb the immune homeostasis in chickens, while treatment with antibiotics (enrofloxacin or colistin) caused cytokine imbalance, changes in proportions between immune cell subpopulations, and stress axis hyperactivity [ 16 ]. Thus, antibiotics (especially enrofloxacin) may cause serious adverse effects in poultry, while phage therapy appears safer [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Phage Therapy vs. the Use of Antibiotics in the Treatment of Salmonella-Infected Chickens: Comparison of Effects on Hematological Parameters and Selected Biochemical Markers

Grabowski

Węgrzyn

et al. 2022

Antibiotics

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Previous studies indicated that the use of a phage cocktail, composed of bacteriophages vB_SenM-2 and vB_Sen-TO17, is effective in killing cells of Salmonella enterica serovars Typhimurium and Enteritidis in vitro and in the Galleria mellonella animal model as efficiently as antibiotics (enrofloxacin or colistin) and induced fewer deleterious changes in immune responses. Here, we investigated the effects of this phage cocktail on the hematological parameters and selected biochemical markers in chickens infected with S. enterica serovar Typhimurium, in comparison to those caused by enrofloxacin or colistin. We found that treatment with antibiotics (especially with enrofloxacin) caused nonbeneficial effects on red blood cell parameters, including hematocrit, MCV, MCH, and MCHC. However, Salmonella-induced changes in the aforementioned parameters were normalized by the use of the phage cocktail. Importantly, hepatotoxicity was suggested to be induced by both antibiotics on the basis of increased alanine transaminase (ALT) and aspartate aminotransferase (AST) activities, in contrast to the phage cocktail, which did not influence these enzymes. We conclude that phage therapy with the cocktail of vB_SenM-2 and vB_Sen-TO17 in Salmonella-infected chickens is not only as effective as antibiotics but also significantly safer for the birds than enrofloxacin and colistin.

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“…Pregnant women are given a minimum of 90 tablets during pregnancy (Nidianti et al, 2019). The most prevalent nutritional deficiency affecting pregnant women of both genders and all ages is anemia (Saleem, Muhammed, Al-Hetty, & Salman, 2022).…”

Section: Introductionmentioning

confidence: 99%

Difference in Hemoglobin Value Between Prick Test and Venous Puncture: Implication of Iron Supplementation in Pregnant Women in Primary Health Care, Bengkulu, Indonesia

Maulidyanti

Pramatirta

Sahiratmadja

2022

bic

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Anemia during pregnancy is associated with an increased risk of preterm delivery, low birth weight, and bleeding. Therefore, the National program for 90 iron tables during pregnancy has been employed. Hemoglobin (Hb) monitoring has not been routinely conducted, hence, the Hb examination is performed by using a simple finger prick test. Our study aimed to analyse whether pregnant women have an increased hemoglobin value after 30 extra tablets and to compare prick test and venous puncture examination among pregnant women after 30 extra tablet. This was analytic research with quasi-experimental study design, with a pre- and post-test approach, conducted in August to September 2022. After consent, pregnant women (n78) who had taken their iron supplementation for at least 3 months were checked for Hb level using finger prick test of whom 18 were still anemic after 3 months iron therapy. Hb level was further examined with venous blood to measure complete blood count measurement and to compare with the result of finger prick test result. Interestingly, CBC result showed that only 2 out of 17 pregnant women were anemic By CBC test. Erythrocyte Shine & Lal Index (MCV*MCV*MCH/100) had suggested that all pregnant women had iron deficiency anemia (cut off value SLI >1530), as confirmed with normal value of HbA2 (2-3.5%). Measurement of Hb in pregnant women in low resource areas is very important. The finger prick test in this study showed a high frequency of anemia, albeit the venous complete blood count showed otherwise. The standardized method for CBC in primary health care is recommended to avoid iron over supplementation. Since Indonesia is located in thalassemia belt., further exploration for those who are still anemic after complete iron tablet in pregnant women is imperative.

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Physiological, hematological and some biochemical alterations during pregnancy

Cited by 3 publications

References 36 publications

Risk factors for iron metabolic disorders in newly diagnosed B-chronic lymphocytic leukemia patients

Risk factors for iron metabolic disorders in newly diagnosed B-chronic lymphocytic leukemia patients

Phage Therapy vs. the Use of Antibiotics in the Treatment of Salmonella-Infected Chickens: Comparison of Effects on Hematological Parameters and Selected Biochemical Markers

Difference in Hemoglobin Value Between Prick Test and Venous Puncture: Implication of Iron Supplementation in Pregnant Women in Primary Health Care, Bengkulu, Indonesia

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