Changes in maternal serum alpha‐fetoprotein levels associated with intrauterine genetic diagnostic procedures

Simpson, Gary F.; Sun, Nian-hu; Golbus, Mitchell S.

doi:10.1002/pd.1970040308

Cited by 10 publications

(3 citation statements)

References 13 publications

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“…MSAFP was found to rise over 40 per cent in 76 per cent of the patients; however, the actual amount of calculated FMB is less than 0.1 ml. The chance of Rh isoimmunization with this small amount of FMB is 3 per cent (Zipursky and Israels, 1967). Therefore, 50 pg of Anti D IgG may be sufficient to avoid maternal isoimmunization and the possibility of enhancement in an Rh negative mother.…”

Section: Resultsmentioning

confidence: 97%

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Chorionic villi sampling changes maternal serum alpha‐fetoprotein

Mariona

Bhatia

Syner³

et al. 1986

Prenatal Diagnosis

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Second trimester amniocentesis has traditionally been utilized for prenatal genetic diagnosis. Chorionic villi sampling (CVS) is presently offered as an alternative. The occurrence of fetomaternal bleed (FMB) during CVS could increase the rate of post sampling abortion and, additionally, be of significance in patients at risk for isoimmunization. Detection and quantitation of FMB can be accomplished by the determination of changes in maternal serum alpha-fetoprotein (MSAFP) before and after CVS.

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Section: Resultsmentioning

confidence: 97%

“…To evaluate FMB related to genetic amniocentesis, the Kleihauer-Betke (KB) test and maternal serum determination of alpha-fetoprotein (AFP) have been advocated (Simpson et al, 1984;Horacek et al, 1976;Leleet al, 1982). Leleet al (1982) have found the latter to be a more sensitive indicator of FMB.…”

Section: Introductionmentioning

confidence: 99%

Chorionic villi sampling changes maternal serum alpha‐fetoprotein

Mariona

Bhatia

Syner³

et al. 1986

Prenatal Diagnosis

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“…Fetomaternal hemorrhage (FMH) has been investigated after amniocentesis [1][2][3][4][5][6][7][8][9], fetoscopy and placentesis [10,11] and also after cordocentesis [12][13][14]. Fetomaternal bleeding following fetal sampling techniques is not rare and has been currently detected by either maternal serum ·-fetoprotein measurement, or the Kleihauer-Betke staining technique.…”

Section: Introductionmentioning

confidence: 99%

Detection and Measurement of Fetomaternal Hemorrhage following Diagnostic Cordocentesis

Chitrit

Caubel²,

Lusina³

et al. 1998

Fetal Diagn Ther

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Objective: The aim of this study was to investigate the effect of cordocentesis on fetomaternal hemorrhage (FMH). Methods: One hundred and three diagnostic cordocenteses, without any other associated procedure, were performed at 23–40 weeks’ gestation. FMH was detected using the Kleihauer-Betke staining of maternal blood taken immediately before and after cordocentesis. Results: Significant FMH occurred after 40 (38.8%) of the 103 procedures. An increased risk of fetal bleeding was associated with both an anterior placenta (odds ratio (OR) 5.89; 95% confidence interval (CI) 2.27–15.3; p < 0.001) and a transplacental cordocentesis (OR 37.0; 95% CI 2.15–636; p < 0.001). The volume of FMH was greater after cordocentesis with an anterior placenta (90th percentile 6.20 ml) than after cordocentesis with a lateral (90th percentile 4.58 ml) or posterior placenta (90th percentile 1.35 ml) (p < 0.001). After fetal blood sampling, significant FMH occurred more frequently with a procedure duration of 3 min or more (OR 4.45; 95% CI 1.70–11.7; p = 0.002) and with two or more needle insertions (OR 4.65; 95% CI 1.80–12.1; p = 0.001). Conclusion: FMH following cordocentesis may be related to placental injuries. This event is influenced by placental location, procedure duration and the number of needle insertions.

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