Changes in Microbiota and Development of Nonspecific Inflammation of Genitals in Female C57Bl/6 Mice after Aerosol Infection with Mycobacterium tuberculosis

Kayukova, S. I.; Донников, А Е; Бочарова, И. В.; Туманова, Е Л; Gergert, V. Ya.; Ergeshov, Atadzhan; Никоненко, Б. В.

doi:10.1007/s10517-019-04589-8

Cited by 2 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Проведенное морфологическое исследование показало отсутствие признаков воспаления в репродуктивных органах самок мышей линии С57BL/6 через 3 и 7 сут после воздушно-капельного инфицирования М. tuberculosis. С увеличением сроков инфицирования (через 15, 32 и 62 дня) регистрировали развитие неспецифического воспаления в виде эозинофильной и лимфоцитарной инфильтрации от незначительной до умеренной степени выраженности, которые расценивали как проявление местной токсико-аллергической (параспецифической) реакции в ответ на инфицирование и последовательное развитие туберкулезного процесса [7].…”

Section: неспецифические воспалительные изменения в репродуктивных орunclassified

“…В обоих экспериментах морфологическое исследование репродуктивных органов (влагалища и маточных рогов) у самок мышей линии C57BL/6, независимо от пути инфицирования М. tuberculosis, установило развитие неспецифического тканевого воспаления через 14-15 дней инфицирования, которое имело тенденцию к хронизации через 62-90 дней. Примечателен факт, что при внутривенном введении М. tuberculosis обнаружены в маточных рогах ДНК М. tuberculosis на всех сроках инфицирования и М. tuberculosis через 90 дней инфицирования, при воздушно-капельном введении М. tuberculosis отсутствовали ДНК М. tuberculosis, М. tuberculosis, гистологических признаков генитального туберкулеза не выявлено при обоих методах инфицирования [7,11].…”

Section: неспецифические воспалительные изменения в репродуктивных орunclassified

See 1 more Smart Citation

Reproductive disorders in the experimental modeling of tuberculosis

Каюкова

Sterzhanova

Никоненко

2020

Tuberk. bolezni lëgk.

Self Cite

View full text Add to dashboard Cite

Section: неспецифические воспалительные изменения в репродуктивных орunclassified

Reproductive disorders in the experimental modeling of tuberculosis

Каюкова

Sterzhanova

Никоненко

2020

Tuberk. bolezni lëgk.

Self Cite

View full text Add to dashboard Cite

“…A healthy equilibrium formed a mutually beneficial relationship with their hosts and provided a barrier to pathogenic organisms ( Chee et al, 2020 ). Pathogenic bacterial infections, including Neisseria gonorrhoeae , HPV, and mycobacterium tuberculosis infection, can cause a dysbiosis of the vaginal microbiome ( Kayukova et al, 2019 ; Tamarelle et al, 2019 ), which, in turn, is thought to influence the outcome of their infections.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus Modulates Chlamydia Infectivity and Genital Tract Pathology in vitro and in vivo

et al. 2022

View full text Add to dashboard Cite

Since we previously reported that women infected with chlamydia had a significant overall reduction in Lactobacillus in the vagina microbiota as compared to those uninfected individuals; the interactions between the altered Lactobacillus and Chlamydia trachomatis, on the other hand, need to be elucidated. Here, we employed both in vitro and in vivo models to evaluate the effects of this changed Lactobacillus on Chlamydia infection. We found that L. iners, L. crispatus, L. jensenii, L. salivarius, L. gasseri, L. mucosae, and L. reuteri all significantly reduced C. trachomatis infection in a dose- and time-dependent manner. The strongest anti-Chlamydia effects were found in L. crispatus (90 percent reduction), whereas the poorest was found in L. iners (50 percent reduction). D (–) lactic acid was the key component in Lactobacillus cell-free supernatants (CFS) to inactivate Chlamydia EBs, showing a positive correlation with the anti-Chlamydia activity. The effects of D (–) lactic acid were substantially attenuated by neutralizing the pH value to 7.0. In vivo, mice intravaginally inoculated with Lactobacillus mixtures (L. crispatus, L. reuteri, and L. iners at a ratio of 1:1:1), but not single Lactobacillus, after genital Chlamydia infection, significantly attenuated the levels of Chlamydia live organism shedding in both the lower genital tract and the intestinal tract, reduced cytokines production (TNF-α, IFN-γ, and IL-1β) in the vagina, and lessened upper genital tract inflammation and pathogenicity. Taken together, these data demonstrate that Lactobacillus inhibits Chlamydia infectivity both in vivo and in vitro, providing useful information for the development of Lactobacillus as adjunctive treatment in Chlamydia infection.

show abstract

Changes in Microbiota and Development of Nonspecific Inflammation of Genitals in Female C57Bl/6 Mice after Aerosol Infection with Mycobacterium tuberculosis

Cited by 2 publications

References 12 publications

Reproductive disorders in the experimental modeling of tuberculosis

Reproductive disorders in the experimental modeling of tuberculosis

Lactobacillus Modulates Chlamydia Infectivity and Genital Tract Pathology in vitro and in vivo

Contact Info

Product

Resources

About