Changes in monoamines of rat brain during postnatal ontogeny

Agrawal, Harish C.; Glisson, Silas N.; Himwich, Williamina A.

doi:10.1016/0304-4165(66)90247-9

Cited by 104 publications

(19 citation statements)

References 12 publications

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“…The development of monoamine systems in the rat has been studied by Agrawal, Glisson & Himwich (1966). Our interest in the administration of 6-hydroxydopamine to developing animals was to determine if neuronal damage to noradrenergic neurones would occur before they were totally developed.…”

Section: Discussionmentioning

confidence: 99%

Depletion of brain noradrenaline and dopamine by 6‐hydroxydopamine

Breese¹,

Traylor²

1971

British J Pharmacology

528

135

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Summary1. After intracisternal administration, 6-hydroxydopamine had a greater effect on brain noradrenaline than on dopamine. 2. Administration of two doses of 6-hydroxydopamine increased the depletion of noradrenaline but not of dopamine.3. Small doses of 6-hydroxydopamine decreased the concentration of noradrenaline with little or no effect on dopamine. Tyrosine hydroxylase activity was not reduced with these treatments.4. While pargyline pretreatment offered no advantage in the depletion of brain noradrenaline after 6-hydroxydopamine, depletion of brain dopamine was greatly potentiated by this treatment. The reduction of striatal tyrosine hydroxylase activity observed after 6-hydroxydopamine was also potentiated by pargyline pretreatment. 5. The amounts of labelled noradrenaline and dopamine formed from 3H-tyrosine were greatly reduced by 6-hydroxydopamine treatment. After 3H-DOPA, formation of noradrenaline was greatly reduced while formation of labelled dopamine was only moderately reduced suggesting that decarboxylation of DOPA can occur in other than catecholamine containing neurones. 6. Desmethylimipramine and imipramine inhibited depletion of noradrenaline produced by 6-hydroxydopamine but did not alter depletion of dopamine.Reserpine did not inhibit depletion of catecholamines produced by 6-hydroxydopamine. 7. Administration of 6-hydroxydopamine to developing rats lowered both noradrenaline and dopamine concentrations as well as the tyrosine hydroxylase activity in the brains of these animals.

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Section: Discussionmentioning

confidence: 99%

Depletion of brain noradrenaline and dopamine by 6‐hydroxydopamine

Breese¹,

Traylor²

1971

British J Pharmacology

528

135

View full text Add to dashboard Cite

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“…While several previous studies have investigated the course of development of brain noradrenaline and dopamine in the rat (Agrawal et al, 1966;Karki et al, 1962;Loizou & Salt, 1970;Loizou, 1971), tyrosine hydroxylase had not previously been examined in this species. In agreement with earlier reports, noradrenaline and dopamine were found to be present in brain at birth.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the newborn rat whose functional development is poor, had low concentrations of monoamines. In an extension of this work Agrawal, Glisson & Himwich (1966 studied the progress of the development of the monoamines in the mouse and rat and confirmed that monoamines were low at birth and progressively increased to adult concentrations. More recently, Loizou & Salt (1970) have suggested that the progressive increase in the concentrations of brain monoamines in the rat is a consequence of the progressive proliferation of axon terminals.…”

Section: Introductionmentioning

confidence: 99%

Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6‐hydroxydopamine

Breese¹,

Traylor²

1972

British J Pharmacology

200

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“…Loizou and Salt (7) suggested that the increases in monoamine concentrations in the brain during development result from proliferation of axon terminals. Ontogenetic increases in brain monoamines are greater in the early postnatal period than in utero, suggesting that growth and maturation of the central aminergic system are mainly postnatal events (8)(9)(10)(11)(12).…”

mentioning

confidence: 99%

Effects of postnatal undernutrition on the catecholamine and serotonin contents of suckling rat brain.

Hisatomi

Niiyama

1980

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effect of postnatal undernutrition on the catecholamine and serotonin contents of various parts of the brain of suckling rats was examined. Undernourishment was induced by increasing the litter size to 18 pups from day 1 to 21 after birth. In control pups, the total amounts of norepinephrine and dopamine in the whole brain increased greatly during the suckling period (norepinephrine: 17.7ng at birth, 154ng on day 10, and 420ng on day 21; dopamine: 12.6ng at birth, 269ng on day 10, and 1,022ng on day 21). Similar, but less marked increases in the norepinephrine and dopamine contents of the brain were observed in malnourished pups. The norepinephrine contents of the forebrain, cerebellum, and brain stem of malnourished pups were comparable with those of normal pups on day 10 but the contents of the cerebellum and brain stem were significantly less than those of normal pups on day 21. Postnatal malnutrition also led to a significant decrease in the dopamine content of the forebrain. In contrast, the serotonin content of the brain of undernourished pups was significantly higher than that of controls. The activities of tyrosine hydroxylase in the forebrain and brain stem of control pups at the end of suckling period were significantly higher than those of undernourished pups (forebrain: 18.3pmol in controls and 11.5 pmol in malnourished pups; brain stem: 12.3pmol in controls and 9.8 pmol in malnourished pups). The tyrosine hydroxylase activity (pmol/g) correlated more closely with the norepinephrine content than with the dopamine or norepinephrine plus dopamine content. The tyrosine and phenylalanine contents of the brain were similar in the two groups. It is concluded from these findings that the catecholamine content of the brain is regulated by the enzyme activity rather than the levels of precursor amino acids. Keywords brain catecholamine (CA), serotonin, tyrosine hydroxylase, early postnatal malnutrition, lactation, brain free amino acids 279

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Changes in monoamines of rat brain during postnatal ontogeny

Cited by 104 publications

References 12 publications

Depletion of brain noradrenaline and dopamine by 6‐hydroxydopamine

Depletion of brain noradrenaline and dopamine by 6‐hydroxydopamine

Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6‐hydroxydopamine

Effects of postnatal undernutrition on the catecholamine and serotonin contents of suckling rat brain.

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