Changes in muscle blood flow distribution during hyperthermia

Akyurekli, D.U.; Gerig, L; Raaphorst, G. P.

doi:10.3109/02656739709023547

Cited by 50 publications

(40 citation statements)

References 26 publications

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“…2012), an observation which is consistent with the local responses seen in porcine skeletal muscle with microwave heating (Akyürekli et al . 1997), and the responses to different thermal interventions of the human lower leg muscles (Heinonen et al . 2011) and the profunda femoral artery, which primarily supplies blood to the thigh muscles (Chiesa et al .…”

Section: Introductionmentioning

confidence: 99%

Mechanisms for the control of local tissue blood flow during thermal interventions: influence of temperature‐dependent ATP release from human blood and endothelial cells

Kalsi

Chiesa

Trangmar

et al. 2017

Experimental Physiology

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New Findings What is the central question of this study? Skin and muscle blood flow increases with heating and decreases with cooling, but the temperature‐sensitive mechanisms underlying these responses are not fully elucidated. What is the main finding and its importance? We found that local tissue hyperaemia was related to elevations in ATP release from erythrocytes. Increasing intravascular ATP augmented skin and tissue perfusion to levels equal or above thermal hyperaemia. ATP release from isolated erythrocytes was altered by heating and cooling. Our findings suggest that erythrocytes are involved in thermal regulation of blood flow via modulation of ATP release. Local tissue perfusion changes with alterations in temperature during heating and cooling, but the thermosensitivity of the vascular ATP signalling mechanisms for control of blood flow during thermal interventions remains unknown. Here, we tested the hypotheses that the release of the vasodilator mediator ATP from human erythrocytes, but not from endothelial cells or other blood constituents, is sensitive to both increases and reductions in temperature and that increasing intravascular ATP availability with ATP infusion would potentiate thermal hyperaemia in limb tissues. We first measured blood temperature, brachial artery blood flow and plasma [ATP] during passive arm heating and cooling in healthy men and found that they increased by 3.0 ± 1.2°C, 105 ± 25 ml min−1 °C−1 and twofold, respectively, (all P < 0.05) with heating, but decreased or remained unchanged with cooling. In additional men, infusion of ATP into the brachial artery increased skin and deep tissue perfusion to levels equal or above thermal hyperaemia. In isolated erythrocyte samples exposed to different temperatures, ATP release increased 1.9‐fold from 33 to 39°C (P < 0.05) and declined by ∼50% at 20°C (P < 0.05), but no changes were observed in cultured human endothelial cells, plasma or serum samples. In conclusion, increases in plasma [ATP] and skin and deep tissue perfusion with limb heating are associated with elevations in ATP release from erythrocytes, but not from endothelial cells or other blood constituents. Erythrocyte ATP release is also sensitive to temperature reductions, suggesting that erythrocytes may function as thermal sensors and ATP signalling generators for control of tissue perfusion during thermal interventions.

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Section: Introductionmentioning

confidence: 99%

Mechanisms for the control of local tissue blood flow during thermal interventions: influence of temperature‐dependent ATP release from human blood and endothelial cells

Kalsi

Chiesa

Trangmar

et al. 2017

Experimental Physiology

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“…2 However, the extent of these physiological effects varies based on the type of heating modality and its depth of penetration. 24,22 It has been suggested that many of the physiological benefits of heating occur when muscle temperatures are raised by at least 2°C.…”

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confidence: 99%

Effect of diathermy on muscle temperature, electromyography, and mechanomyography

et al. 2008

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This study examined the effects of pulsed shortwave diathermy on intramuscular temperature, surface electromyography (EMG), and mechanomyography (MMG) of the vastus lateralis. Thirty-five men were assigned to diathermy (n = 13), sham-diathermy (n = 12), or control (n = 10) groups. Each subject performed isometric maximal voluntary contractions (MVCs) and incremental ramp contractions (10%-90% MVC) before and after treatment. Torque, intramuscular temperature, EMG, and MMG were recorded. Temperature for the diathermy group increased (P

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“…Furthermore, a significant plant-model mismatch should be expected: An accurate patient-and site-specific model of the treatment is difficult to develop, and the process is known to change during treatment. For example, the target may move or swell, or blood perfusion may increase significantly in response to the elevated temperature [31], which strongly influences temperature distribution in the target, as well as in the healthy tissue.…”

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confidence: 99%

Minimum-Time Thermal Dose Control of Thermal Therapies

Arora

Skliar

Roemer

2005

IEEE Trans. Biomed. Eng.

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The problem of controlling noninvasive thermal therapies is formulated as the problem of directly controlling thermal dose of the target. To limit the damage to the surrounding normal tissue, the constraints on the peak allowable temperatures in the selected spacial locations are imposed. The developed controller has a cascade structure with a linear, constrained, model predictive temperature controller in the secondary loop. The temperature controller manipulates the intensity of the ultrasound transducer with saturation constraints, which noninvasively heats the spatially distributed target. The main nonlinear thermal dose controller dynamically generates the reference temperature trajectories for the temperature controller. The thermal dose controller is designed to force the treatment progression at either the actuation or temperature constraints, which is required to minimize the treatment time. The developed controller is applicable to high and low-intensity treatments, such as thermal ablation and thermoradiotherapy. The developed approach is tested using computer simulations for a one-dimensional model of a tumor with constraints on the maximum allowable temperature in the normal tissue and a constrained power output of the ultrasound transducer. The simulation results demonstrate that the proposed approach is effective at delivering the desired thermal dose in a near minimum time without violating constraints on the maximum allowable temperature in healthy tissue, despite significant plant-model mismatch introduced during numerical simulation. The results of in vitro and in vivo validation are reported elsewhere.

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Changes in muscle blood flow distribution during hyperthermia

Cited by 50 publications

References 26 publications

Mechanisms for the control of local tissue blood flow during thermal interventions: influence of temperature‐dependent ATP release from human blood and endothelial cells

Mechanisms for the control of local tissue blood flow during thermal interventions: influence of temperature‐dependent ATP release from human blood and endothelial cells

Effect of diathermy on muscle temperature, electromyography, and mechanomyography

Minimum-Time Thermal Dose Control of Thermal Therapies

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