Changes in muscle mass, fat mass, and bone mineral content in the legs after stroke: a 1 year prospective study

Jørgensen, Lone; Jacobsen, Bjarne K.

doi:10.1016/s8756-3282(01)00434-3

Cited by 172 publications

(146 citation statements)

References 26 publications

Supporting

Mentioning

139

Contrasting

Unclassified

Order By: Relevance

“…Generally, impaired feeding, reduced caloric intake, and loss of appetite lead to a negative nutritional and nitrogen balance, 56,57 and immobilization causes physical inactivity and muscle atrophy after stroke. 58,59 It has been shown that elevated volumes of TNF-α are responsible for muscle loss and that plasma concentrations of the enzyme visfatin were significantly elevated in patients after ischemic stroke. 60,61 For that, investigations to changes of inflammation parameters and its relation to body composition, insulin sensitivity, and patient's survival will be made as well.…”

Section: Current Developments On Muscle Mass Lossmentioning

confidence: 99%

Loss of muscle mass: Current developments in cachexia and sarcopenia focused on biomarkers and treatment

Drescher

Konishi

Ebner

et al. 2016

International Journal of Cardiology

View full text Add to dashboard Cite

Section: Current Developments On Muscle Mass Lossmentioning

confidence: 99%

Loss of muscle mass: Current developments in cachexia and sarcopenia focused on biomarkers and treatment

Drescher

Konishi

Ebner

et al. 2016

International Journal of Cardiology

View full text Add to dashboard Cite

“…Third, the most rapid bone loss occurs in the acute and subacute phase of stroke recovery (<6 months) followed by a slower progressive bone loss in the chronic stage [39,43,[46][47]54,58]. In a 1-year prospective study, those who had severe paresis in the upper limb sustained a 23 percent loss in BMD in the proximal humerus within the first 7 months poststroke and an additional 4 percent loss at 1 year [43].…”

Section: Stroke: a Model Of Disuse Osteoporosismentioning

confidence: 99%

Balance, falls, and bone health: Role of exercise in reducing fracture risk after stroke

Eng

Pang

Ashe

2008

JRRD

View full text Add to dashboard Cite

Abstract-Fractures occur frequently in people living with stroke and have high personal, social, and economic costs for these individuals, their families, and the community. Exercise to reduce the risk of fragility fractures is a relatively new application in stroke rehabilitation but is a promising treatment with the potential to reduce the incidence of falls as well as maintain or improve bone health. In this article, we outline fracture risk factors and provide an overview of exercise interventions aimed at reducing fracture risk poststroke. Although randomized controlled trials support the use of exercise to reduce fracture risk factors poststroke, the body of literature is small and further studies are required. Further, the optimal dose of exercise and the additive effects of pharmacology on fracture risk need to be determined. Given the many health benefits associated with exercise, it should be considered an important modality for the management of falls and maintenance of bone health following stroke.

show abstract

“…Decline of muscle mass has been observed in stroke patients within first three weeks after hemiparetic stroke 5. Further, patients who are not able to relearn walking within 2 months after stroke revealed similar lean mass reduction in paretic and non‐paretic leg 6. A combination of mechanisms, including immobilization, disuse, inflammation, metabolic, and neurovegetative imbalance after stroke, results frequently in muscle wasting and may progress to the stroke‐related sarcopenia 1, 7.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of C-terminal Agrin Fragment as a marker of muscle wasting in patients after acute stroke during early rehabilitation

Scherbakov

Knops

Ebner³

et al. 2015

Journal of Cachexia, Sarcopenia and Muscle

View full text Add to dashboard Cite

BackgroundC‐terminal Agrin Fragment (CAF) has been proposed as a novel biomarker for sarcopenia originating from the degeneration of the neuromuscular junctions. In patients with stroke muscle wasting is a common observation that predicts functional outcome. We aimed to evaluate agrin sub‐fragment CAF22 as a marker of decreased muscle mass and physical performance in the early phase after acute stroke.MethodsPatients with acute ischaemic or haemorrhagic stroke (n = 123, mean age 70 ± 11 y, body mass index BMI 27.0 ± 4.9 kg/m2) admitted to inpatient rehabilitation were studied in comparison to 26 healthy controls of similar age and BMI. Functional assessments were performed at begin (23 ± 17 days post stroke) and at the end of the structured rehabilitation programme (49 ± 18 days post stroke) that included physical assessment, maximum hand grip strength, Rivermead motor assessment, and Barthel index. Body composition was assessed by bioelectrical impedance analysis (BIA). Serum levels of CAF22 were measured by ELISA.ResultsCAF22 levels were elevated in stroke patients at admission (134.3 ± 52.3 pM) and showed incomplete recovery until discharge (118.2 ± 42.7 pM) compared to healthy controls (95.7 ± 31.8 pM, p < 0.001). Simple regression analyses revealed an association between CAF22 levels and parameters of physical performance, hand grip strength, and phase angle, a BIA derived measure of the muscle cellular integrity. Improvement of the handgrip strength of the paretic arm during rehabilitation was independently related to the recovery of CAF22 serum levels only in those patients who showed increased lean mass during the rehabilitation.ConclusionsCAF22 serum profiles showed a dynamic elevation and recovery in the subacute phase after acute stroke. Further studies are needed to explore the potential of CAF22 as a serum marker to monitor the muscle status in patients after stroke.

show abstract

Changes in muscle mass, fat mass, and bone mineral content in the legs after stroke: a 1 year prospective study

Cited by 172 publications

References 26 publications

Loss of muscle mass: Current developments in cachexia and sarcopenia focused on biomarkers and treatment

Loss of muscle mass: Current developments in cachexia and sarcopenia focused on biomarkers and treatment

Balance, falls, and bone health: Role of exercise in reducing fracture risk after stroke

Evaluation of C-terminal Agrin Fragment as a marker of muscle wasting in patients after acute stroke during early rehabilitation

Contact Info

Product

Resources

About