Changes in Oxidation-antioxidation Function on the Thymus of Chickens Infected with Reticuloendotheliosis Virus

Abstract

Background Reticuloendotheliosis virus (REV) is a retrovirus that causes severe immunosuppression in infected poultry. Under oxidative stress,the animals grow slowly. In addition, long-term oxidative stress can impair immune function, as well as accelerate the aging and death of the animal.This study aimed to elucidate the pathogenesis of REV from the perspective of changes in oxidative-antioxidative function following REV infection. Results In specific pathogen free chickens infected with REV, the levels of H2O2 and MDA in the thymus increased, the levels of T-AOC, SOD, CAT, and GPx1 decreased, and there was a reduction in CAT and Gpx1 mRNA expression, compared with the control group. The thymus index was also significantly reduced. Morphological analysis showed that after REV infection, there was an increase in thymic reticular endothelial cells, inflammatory cell infiltration, mitochondrial swelling, and destruction of the nuclear structure. Conclusions These results indicate that an increase in oxidative substances within the thymus, enhanced lipid peroxidation, a markedly decrease in antioxidant function, atrophy of the thymus, and immunosuppression in REV-infected chickens.

Maternal oxidized soybean oil exposure in rats during lactation damages offspring kidneys via Nrf2/HO‐1 and NF‐κB signaling pathway

“…In this study, Sod and Cat mRNA levels were decreased in the OSO lactating rats. Following a previous study, oxidative stress can reduce the gene expression of Sod and Cat 41 . Nrf2 also will activate downstream genes; for instance, Gclc , Gclm , Nqo1 , and Ho‐1 42 .…”

“…Following a previous study, oxidative stress can reduce the gene expression of Sod and Cat. 41 Nrf2 also will activate downstream genes; for instance, Gclc, Gclm, Nqo1, and Ho-1. 42 HO-1 and NQO1 are protein antioxidant defense components of the Nrf2 signaling pathway and exert significant antioxidant functions.…”