Changes in oxidative metabolism in selected tissues of the crab (Scylla serrata) in response to cadmium toxicity

Immunobiochemical modulations caused by clomazone in Swiss albino mice

“…The present results showed a significant decrease in mice serum total protein and LDH in response to CMZ toxicity. In agreement with the present data, Canli (1996) and Reddy and Bhagyalakshmi (1994) report a decrease in total protein content in fish during mercury exposure. Pesticide-induced tissue destruction and hepatocyte apoptosis might be the most important agent responsible of reducing the synthesis of total protein in the liver (Gokcimen et al, 2007).…”

Certain Metals Trigger Fibrillation of Methionine-oxidized α-Synuclein

“…It is likely that there are chaperones or chaperone-like species that are important in minimizing ␣-synuclein aggregation under normal conditions. In our earlier study, showing that the addition of Met-oxidized ␣-synuclein inhibited fibrillation of the non-oxidized form (33), we suggested that the methionine residues in ␣-synuclein may be used by the cells as a natural scavenger of reactive oxygen species, since (a) methionine can react with essentially all of the known oxidants found in normal and pathological tissues; (b) ␣-synuclein is a very abundant brain protein; (c) it has recently been shown that the concentration of ␣-synuclein could be increased significantly as a result of the neuronal response to toxic insult (23); and (d) methionine sulfoxide residues in proteins can be cycled back to their native methionines by methionine sulfoxide reductase (38), a process that might protect other functionally essential residues from oxidative damage (39). It should be noted, however, that the efficiency of this regeneration system must take into account the finding that methionine oxidation forms the sulfoxide in two diastereoisomer forms and that stereoselective oxidation can sometimes occur, dependent on both the structural restraints in the region of the methionine molecule and on the oxidant itself (40).…”

13-Cis-Retinoic Acid-Induced Hyperglycemia in the Fresh Water Edible Crab, Oziothelphusa Senex Senex is mediated by Triggering Release of Hyperglycemic Hormone from Eyestalks

“…It is also known that elevated circulating titres of CHH were reported to occur following exposure to several environmental stressors [24,25] in intact but not in eyestalk ablated crabs, suggesting stress-induced hyperglycemia is CHH mediated response [26][27][28][29].…”