Changes in Plasma Glucose in Otsuka Long-Evans Tokushima Fatty Rats After Oral Administration of Maple Syrup

Nagai, Noriaki; Yamamoto, Tetsushi; Tanabe, Wataru; Ito, Yoshimasa; Kurabuchi, Satoshi; Mitamura, Kuniko; Taga, Atsushi

doi:10.5650/jos.ess14075

Cited by 14 publications

(16 citation statements)

References 17 publications

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“…The sugar maple is distributed throughout North America, and maple trees serve an important role in traditional medicine among Native Americans (19). A number of previous studies have examined the chemical composition and biological properties of maple-derived products, including maple syrup (20–26).…”

Section: Introductionmentioning

confidence: 99%

Dark‑colored maple syrup treatment induces S‑phase cell cycle arrest via reduced proliferating cell nuclear antigen expression in colorectal cancer cells

2019

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Maple syrup is a natural sweetener that is consumed worldwide. It has been previously reported that dark-colored maple syrup exerts an inhibitory effect on colorectal cancer (CRC) proliferation and invasion. In the present study, the underlying mechanism of CRC cell growth inhibition was examined with dark-colored maple syrup treatment using a shotgun liquid chromatography-tandem mass spectrometry-based global proteomic approach. Applying a semi-quantitative method based on spectral counting, 388 proteins were identified with expression changes of >1.5-fold following dark-colored maple syrup treatment. Gene Ontology analysis revealed that these proteins possessed cell cycle-associated functions. It was also indicated that CRC cells treated with dark-colored maple syrup exhibited decreased proliferating cell nuclear antigen (PCNA) expression and S-phase cell cycle arrest. Dark-colored maple syrup treatment also resulted in altered expression of cell cycle-associated genes, including cyclin-dependent kinase (CDK)4 and CDK6. In conclusion, these data suggested that dark-colored maple syrup induced S-phase cell cycle arrest in CRC cells by reducing the expression of PCNA and regulating cell cycle-associated genes. These findings suggest that dark-colored maple syrup may be a source of compounds for the development of novel drugs for colorectal cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Dark‑colored maple syrup treatment induces S‑phase cell cycle arrest via reduced proliferating cell nuclear antigen expression in colorectal cancer cells

2019

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“…An extract of maple syrup rich in polyphenols (MSX) has been reported to inhibit the activity of α-glucosidase in vitro and to decrease the uptake of glucose in HepG2 cells [ 40 ]. Moreover, another team found that administration of maple syrup compared to sucrose in rats reduced plasma glucose levels [ 22 ] and intestinal glucose absorption [ 23 ]. The reduction of glucose absorption they observed was increased when maple syrup was darker, which was associated with an increased antioxidant activity [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, another team found that administration of maple syrup compared to sucrose in rats reduced plasma glucose levels [ 22 ] and intestinal glucose absorption [ 23 ]. The reduction of glucose absorption they observed was increased when maple syrup was darker, which was associated with an increased antioxidant activity [ 23 ]. Thus, we can hypothesize that chronic inhibition of glucose absorption might have provided an advantage for these animals treated with natural sweeteners compared to those treated with sucrose.…”

Section: Discussionmentioning

confidence: 99%

“…It was previously reported that honey consumption limits weight gain, improves dyslipidemia, and reduces glycemia in both human [ 18 , 19 ] and rats [ 20 , 21 ]. Moreover, both maple syrup [ 22 , 23 ] and agave syrup [ 24 ] intake has been shown to improve glucose homeostasis compared to sucrose. Yet, honey is mostly composed of an equal mix of fructose and glucose, maple syrup is 97% sucrose and agave 90% fructose.…”

Section: Introductionmentioning

confidence: 99%

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Differential Effects of Chronic Ingestion of Refined Sugars versus Natural Sweeteners on Insulin Resistance and Hepatic Steatosis in a Rat Model of Diet-Induced Obesity

et al. 2020

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While the detrimental effect of refined sugars on health has been the subject of many investigations, little is known about the long-term impact of natural sweeteners on metabolic disorders. In this study we compared the metabolic responses to chronic ingestion of refined sugars compared to various natural sweeteners in diet-induced obese rats. Wistar rats were fed a high-fat high-sucrose diet (HFHS) for 8 weeks and daily gavaged with a solution containing 1 g of total carbohydrates from refined sugar (sucrose or fructose) or six different natural sugar sources, followed by assessment of glucose homeostasis, hepatic lipid accumulation, and inflammation. While glucose tolerance was similar following treatments with refined and natural sugars, lowered glucose-induced hyperinsulinemia was observed with fructose. Consumption of fructose and all-natural sweeteners but not corn syrup were associated with lower insulin resistance as revealed by reduced fasting insulin and homeostatic model assessment of insulin resistance (HOMA-IR) compared to sucrose treatment of HFHS-fed rats. All-natural sweeteners and fructose induced similar liver lipid accumulation as sucrose. Nevertheless, maple syrup, molasses, agave syrup, and corn syrup as well as fructose further reduced hepatic IL-1β levels compared to sucrose treatment. We conclude that natural sweeteners and especially maple syrup, molasses, and agave syrup attenuate the development of insulin resistance and hepatic inflammation compared to sucrose in diet-induced obese rats, suggesting that consumption of those natural sweeteners is a less harmful alternative to sucrose in the context of obesity.

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“… reported the anti‐invasion activity of MS against a colorectal cancer cell line. With respect to in vivo activity, the oral administration of MS or maple sugar reportedly resulted in lower plasma glucose elevation than the administration of an equal amount of sucrose in Otsuka Long‐Evans Tokushima Fatty rats . We have studied the metabolic effects of MS in reference to the hepatic transcriptome in rats and mice.…”

Section: Introductionmentioning

confidence: 99%

Quantitative deviating effects of maple syrup extract supplementation on the hepatic gene expression of mice fed a high‐fat diet

Kamei

Watanabe

Shinozaki

et al. 2016

Molecular Nutrition Food Res

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Changes in Plasma Glucose in Otsuka Long-Evans Tokushima Fatty Rats After Oral Administration of Maple Syrup

Cited by 14 publications

References 17 publications

Dark‑colored maple syrup treatment induces S‑phase cell cycle arrest via reduced proliferating cell nuclear antigen expression in colorectal cancer cells

Dark‑colored maple syrup treatment induces S‑phase cell cycle arrest via reduced proliferating cell nuclear antigen expression in colorectal cancer cells

Differential Effects of Chronic Ingestion of Refined Sugars versus Natural Sweeteners on Insulin Resistance and Hepatic Steatosis in a Rat Model of Diet-Induced Obesity

Quantitative deviating effects of maple syrup extract supplementation on the hepatic gene expression of mice fed a high‐fat diet

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