Changes in plasma levels of per- and polyfluoroalkyl substances (PFAS) are associated with changes in plasma lipids - A longitudinal study over 10 years

Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations

“…An important strength of this study is the longitudinal design and repeated measurement modelling which allowed for robust association testing. In addition, we also investigated the robustness of the partial correlations and GEE approach for repeated measures within the meet-in-the-middle framework and contrasted it to a change-in-change analysis, also adapted to capitalise on repeated measures (Dunder et al, 2022;Fitz-Simon et al, 2013), with similar results. We therefore conclude that observed results were not obtained by modelling artefacts.…”

Determinants of maternal and neonatal PFAS concentrations: a review

“…There is evidence of numerous health effects associated with PFAS exposure in adults, including dyslipidemia [ 14 – 16 ], changes in liver enzymes [ 17 , 18 ], elevated blood pressure and hypertension [ 19 , 20 ], and kidney and testicular cancer [ 21 ]. In neonates and children, there is evidence of decreases in birthweight [ 22 , 23 ], neurobehavioral problems [ 24 – 27 ], immunosuppression [ 28 , 29 ], and increased adiposity [ 30 – 32 ].…”

Associations between Per- and Polyfluoroalkyl Substances Exposures and Blood Lipid Levels among Adults—A Meta-Analysis

“…Of note, studies that examined PFAS and blood lipids repeatedly over time also found a significant correlation between PFOA and TC levels. 30 , 31 , 39 , 41 In contrast, in occupational studies, null associations between PFOA/PFOS and HDL-C levels were observed, 10 , 30 , 37 , 38 , 40 , 43 whereas in general populations, a positive association was more likely to be observed. 24 , 60 Our dose–response analyses and analyses stratified by PFOS/PFOA exposure levels largely reflected these observations in previous individual studies or narrative reviews.…”

“… 81 Furthermore, it is worth noting that our findings are in line with evidence from other prospective studies; that is, that reductions of PFAS levels are associated with reduction of lipids, indicating potential causal relationships. 28 , 31 In addition, baseline blood PFAS concentrations were found to be significantly associated with a higher incidence of hyperlipidemia. 10 We also made several statistical assumptions in data processing to harmonize raw data obtained from studies using different data transformations.…”