Changes in plasma lipid and lipoprotein levels in men and women after a program of moderate exercise.

Brownell, Kelly D.; Bachorik, Paul S.; Ayerle, R S

doi:10.1161/01.cir.65.3.477

Cited by 139 publications

(44 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, several investigators have described age-related changes in lipid and lipoprotein levels, including increases in low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and total cholesterol (TC), and decreases in high-density lipoprotein cholesterol (HDL-C) up to middle age. [1][2][3][4][5][6][7] Physical activity and moderate alcohol consumption are related to decreases in LDL-C and TC, and increases in HDL-C. [8][9][10] In women, the menopausal transition is strongly associated with increases in LDL-C and TC, and in some studies with changes in TG and HDL-C. 2,[11][12][13][14] The majority of these findings, however, are from analyses of cross-sectional data, or from data gathered in studies that had relatively short follow-up periods. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] Adiposity is an important influence on adult lipid and lipoprotein profiles.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7] Physical activity and moderate alcohol consumption are related to decreases in LDL-C and TC, and increases in HDL-C. [8][9][10] In women, the menopausal transition is strongly associated with increases in LDL-C and TC, and in some studies with changes in TG and HDL-C. 2,[11][12][13][14] The majority of these findings, however, are from analyses of cross-sectional data, or from data gathered in studies that had relatively short follow-up periods. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] Adiposity is an important influence on adult lipid and lipoprotein profiles. [15][16][17][18][19][20][21] The body mass index (BMI) is often used as a proxy measure of adiposity and in adults BMI is positively related to LDL-C, TG and TC, and negatively related to HDL-C. 22 However, BMI is a composite of adipose and lean tissues, both of which can have distinct effects on lipid and lipoprotein levels.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: the Fels Longitudinal Study

et al. 2005

View full text Add to dashboard Cite

Introduction: Although lipid profiles tend to worsen with age, it is not fully known if such age-related changes are influenced primarily by body composition and lifestyle or by other aspects of aging. Objective: We investigated the extent to which the fat and fat-free components of body mass index (BMI) and lifestyle factors influence patterns of change in lipids independent of age. Design: Serial data were analyzed using sex-specific longitudinal models. These models use serial data from individuals to assume a general pattern of change over time, while allowing baseline age and the rate of change to vary among individuals. Subjects: Serial data were obtained from 940 examinations of 269 healthy white participants (126 men, 143 women), aged 40-60 years, in the Fels Longitudinal Study. Measurements: Measurements included age, the fat (FMI) and fat-free mass (FFMI) components of BMI, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), triglycerides (TG), total cholesterol (TC), fasting glucose and insulin, physical activity, alcohol use and smoking, and women's menopausal status and estrogen use. Results: In both sexes, increased FMI was significantly associated with increased LDL-C, TG and TC, and decreased HDL-C. Increased FFMI was significantly related to decreased HDL-C and increased TG. Independent age effects remained significant only for LDL-C and TC in men and TC in women. Increased insulin was significantly related to increased TG in women. Moderate alcohol consumption was associated with higher HDL-C in men. Physical activity lowered male LDL-C and TC levels, and increased female HDL-C levels. Menopause was associated with increases in LDL-C. Premenopausal women not using estrogen had significantly lower HDL-C, TG, and TC than postmenopausal women taking estrogen. Conclusions: (1) Age is an important independent predictor for LDL-C and TC in men, and TC in women, but it is not as influential as body composition and lifestyle on HDL-C and TG in men and women, and LDL-C in women. (2) Increasing FMI is the major contributor to elevated TC, LDL-C and TG levels, and decreased HDL-C levels in men and women. (3) FFMI significantly influences HDL and TG levels in both sexes. (4) Maintaining a lower BMI via a reduced fat component may be more beneficial in lowering CVD risks than other factors.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: the Fels Longitudinal Study

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Bailey et al 30) found decreases in serum TC, HDL-C, and LDL-C levels in trained subjects who performed at 70%-85% of their maximum heart rates for 4 weeks, which is different from the findings of the present study. In contrast, 3 months of moderate aerobic exercise did not improve BLLP levels in females 31) . The differences in BLLP levels due to exercise primarily depend on exercise intensity, duration, and frequency, as well as lifestyle factors such as diet, sex, smoking, and alcohol consumption 1,17,32,33) .…”

Section: Correlations Among Variablesmentioning

confidence: 62%

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Turgay

Şişman

Aksu

2015

JAT

View full text Add to dashboard Cite

Aim: Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL). The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1), including basal PON1, salt-stimulated PON1 (SPON1), and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P). Methods: Our study included 18 Turkish national female judoists (mean age: 17.9 0.8 years). Before and after 5 months of anaerobic training, critical speed (CS), TDPON1 activities, cholesterol levels in the serum and supernatants of HDLs obtained by polyethylene glycol, and other major blood lipids and lipoproteins (BLLPs) including triglycerides were determined using blood samples taken after overnight fasting. PON1P groups (PGs) were categorized as QQ (QG; persons with low activity) and R carriers (QR RR) (RG; persons with high activity) according to SPON1/AE activity ratios. The results were considered statistically significant at P ≤ 0.05. Results: Anaerobic training resulted in significantly increased the cholesterol levels of HDLs (except HDL2-C) in all subjects, but not HDLs-C in PGs. Anaerobic training resulted in significant increases in most TDPON1 activities of serum and HDLs in all subjects and (except AE) in PGs, whereas SPON1 and HDL2 AE activities increased only in the RG, which was related to PON1P. However, PON1P was not related to other measured markers, including basal BLLP profiles. Conclusions: Anaerobic training improved most TDPON1 activities of serum and HDLs and HDLs -C levels (except HDL2-C) in all subjects, but not HDLs-C in PGs. The beneficial effects of anaerobic training on SPON1 and HDL2 AE activities were depend on PON1P. The lack of response of HDL2-C to anaerobic exercise will require further research. J Atheroscler Thromb, 2015; 22: 313-326.

show abstract

“…However, results from prospective surveys and intervention studies are equivocal. Five of eight exercise trials conducted among men [17] showed significant increases in HDL-C with exercise. Three of these trials evaluated the effect of exercise in women, but no significant differences were reported.…”

Section: Discussionmentioning

confidence: 98%

Loss of abdominal fat and improvement of the cardiovascular risk profile by regular moderate exercise training in patients with NIDDM

et al. 1995

View full text Add to dashboard Cite

Summary Non-insulin-dependent diabetes mellitus (NIDDM) is associated with an increased cardiovascular risk. Glycaemic control alone is often insufficient to control diabetic dyslipidaemia and other cardiovascular risk factors associated with NIDDM. The present trial was designed to evaluate the effects of physical activity as an adjunct to standard diabetes therapy on the lipid profile, blood pressure, glycaemic control, weight and body fat. Sixteen well-controlled (HbAlc 7.5 %) patients with NIDDM participated in a regular aerobic exercise training programme at 50-70 % maximal effort over 3 months. Thirteen age-and sex-matched patients with NIDDM served as a control group. The 3-month intervention with an increase in physical activity from 92 (mean+SD)+79 to 246+112min per week (p < 0.001) by means of a structured activity programme resulted in significant improvement of plasma lipids with a 20% decrease in triglycerides (p < 0.05), unchanged total cholesterol and increases in high-density lipoprotein and high-density lipoprotein-3 subfraction of 23 % (p < 0.001) and 26 % (p < 0.001), respectively. Systolic and diastolic blood pressure decreased significantly from 138+_ 16 to 130+17mm Hg (p<0.05) and 88+10 to 80+ 10 mmHg (p < 0.001), respectively. Resting heart rate decreased from 81 + 13 to 74 + 14 beats per minute (p <0.001), waist-hip circumference ratio decreased from 0.96_+ 0.11 to 0.92 +_ 0.10 (p < 0.001) and body fat decreased from 35.3+7.2 to 33.0 + 8.0 % (p < 0.001). These effects occurred independently of changes in body weight and glycaemic control, which did not change during the study. This study shows that improvement in physical fitness by introducing regular physical exercise as part of the treatment programme in patients with NIDDM results in a significant amelioration of their cardiovascular risk profile. [Diabetologia (1995[Diabetologia ( ) 38: 1313[Diabetologia ( -1319 Key words Exercise, non-insulin-dependent diabetes mellitus, abdominal fat, blood pressure, heart rate, cholesterol, high-density lipoprotein, high-density lipoprotein-2, high-density lipoprotein-3, triglycerides.Diabetes mellitus is associated with a three-to fivefold increased risk for coronary heart disease (CHD)

show abstract

Changes in plasma lipid and lipoprotein levels in men and women after a program of moderate exercise.

Cited by 139 publications

References 42 publications

Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: the Fels Longitudinal Study

Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: the Fels Longitudinal Study

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Loss of abdominal fat and improvement of the cardiovascular risk profile by regular moderate exercise training in patients with NIDDM

Contact Info

Product

Resources

About