Changes in rabbit lipoprotein properties by dietary cholesterol, and saturated and polyunsaturated fats

Stange, Eduard F.; Agostini, Bruno; Papenberg, J.

doi:10.1016/0021-9150(75)90073-8

Cited by 49 publications

(12 citation statements)

References 44 publications

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“…The distribution of total cholesterol and triglyceride in the lipoprotein fractions of the hypercholesterolemic con trol rabbits is in accordance with earlier findings [24], Com pared with the control group the triglyceride concentra tions in all lipoprotein fractions were elevated (table III). This is in accordance with the findings in uremic man [25], The demonstration of a lower concentration of cholesterol in the VLDL fraction (table III) is in contrast to findings in uremic man [7].…”

Section: Lipoprotein Compositionsupporting

confidence: 79%

Effect of Chronic Uremia on Plasma Lipids and the Aortic Accumulation of Cholesterol in Hypercholesterolemic Rabbits

Kamstrup¹,

Tvedegaard²,

Stender³

1980

Nephron

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14 rabbits were made uremic by extensive cauterization and subsequent removal of the contralateral kidney, resulting in a mean plasma creatinine concentration four times the value observed in a sham-operated control group. The animals were killed after 10 weeks of uremia. During the last 7 weeks the rabbits were fed an individually adjusted amount of cholesterol in order to maintain the same elevated level of plasma cholesterol in both groups. The triglyceride concentration was four times higher in the uremic than in the control group. In spite of the same average level of total plasma cholesterol the uremic rabbits had a lower concentration of cholesterol in the VLDL-fraction than the controls. None of the aortas had intimal lesions macroscopically. There were no significant differences between the two groups in the 48-hour accumulation of radioactive cholesterol or in the amount of free and esterified cholesterol in the aortas. Thus, no significant effect on cholesterol accumulation by uremia in the aorta of hypercholesterolemic rabbits was demonstrated.

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Section: Lipoprotein Compositionsupporting

confidence: 79%

Effect of Chronic Uremia on Plasma Lipids and the Aortic Accumulation of Cholesterol in Hypercholesterolemic Rabbits

Kamstrup¹,

Tvedegaard²,

Stender³

1980

Nephron

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“…The outcomes of serum parameter measurements are shown in Table 2. They reveal significantly elevated fasting plasma levels of TC and LDL cholesterol, which were two orders of magnitude higher, and HDL cholesterol concentration, which was eight-fold higher in HC and six-fold higher HCT rabbits versus the controls, effects that are an expected result of high cholesterol diets [43]. However, elevated levels of HDL cholesterol in WGLL-treated rabbits may indicate a cardioprotective property of the lyophilisate in the context of the beneficial effects of HDL.…”

Section: Discussionmentioning

confidence: 99%

Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits

Bombicz

Priksz

Varga

et al. 2016

IJMS

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The present investigation evaluates the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits. New Zealand rabbits were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks. At the zero- and eight-week time points, echocardiographic measurements were made, along with the determination of basic serum parameters. Following the treatment period, after ischemia-reperfusion injury, hemodynamic parameters were measured using an isolated working heart model. Western blot analyses of heart tissue followed for evaluating protein expression and histochemical study for the atheroma status determination. WGLL treatment mediated increases in fractional shortening; right ventricular function; peak systolic velocity; tricuspidal annular systolic velocity in live animals; along with improved aortic and coronary flow. Western blot analysis revealed WGLL-associated increases in HO-1 protein and decreases in SOD-1 protein production. WGLL-associated decreases were observed in aortic atherosclerotic plaque coverage, plasma ApoB and the activity of LDH and CK (creatine kinase) in plasma. Plasma LDL was also significantly reduced. The results clearly demonstrate that WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders.

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“…and from a normal subject was perfonned after extensive dialysis, as reported above for apoprotein studies. Lipoprotein particles were negatively stained with 0.1 M potassium phosphotungstate (40) other hand, all three affected subjects showed a marked reduction of plasma HDL-cholesterol levels, as determined by ultracentrifugation and selective precipitation of VLDL and LDL. Table I reports compositional studies of plasma lipoproteins in the three affected subjects and in the unaffected daughter (D.E.).…”

Section: Introductionmentioning

confidence: 97%

A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family.

Franceschini¹,

Sirtori²,

Capurso³

et al. 1980

J. Clin. Invest.

436

183

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A B S T R A C T Significant hypertriglyceridemia with a very marked decrease of high density lipoproteins (HDL)-cholesterol levels (7)(8)(9)(10)(11)(12)(13)(14) proteins provided evidence for multiple isoproteins in the apoprotein(apo)-A-I range, with nine different bands being detected instead of the usual four bands observed in normal subjects. Two-dimensional immunoelectrophoresis against apo-A antiserum indicated a clear reduction of apo-A in the alpha electrophoretic region, with splitting of the protein "peak." The observation in otherwise clinically healthy subjects of hypertriglyceridemia, reduced HDL-cholesterol, and marked apoprotein abnormalities, without a significant incidence of atherosclerotic disease in the family suggests this is a new disease entity in the field of lipoprotein pathology, very probably related to an altered amino acid composition of the apo-A-I protein (see Weisgraber et al. 1980. J. Clin. Invest. 66: 901-907).

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Changes in rabbit lipoprotein properties by dietary cholesterol, and saturated and polyunsaturated fats

Cited by 49 publications

References 44 publications

Effect of Chronic Uremia on Plasma Lipids and the Aortic Accumulation of Cholesterol in Hypercholesterolemic Rabbits

Effect of Chronic Uremia on Plasma Lipids and the Aortic Accumulation of Cholesterol in Hypercholesterolemic Rabbits

Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits

A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family.

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