Changes in regional blood flow distribution induced by infusions of dopexamine hydrochloride or dobutamine in anesthetized dogs

Biro, George P.; Douglas, Jennifer R.; Keon, Wilbert J.; Taichman, Gerald C.

doi:10.1016/s0002-9149(88)80064-x

Cited by 35 publications

(16 citation statements)

References 15 publications

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“…Under the same conditions, mesenteric and renal vascular conductances were either unchanged or, in the case of the latter during the higher dose infusion, reduced. While a relatively selective hindquarters vasodilator effect of (±)-dobutamine has been described previously (Vatner et al, 1974;Robie & Goldberg, 1975;Liang & Hood, 1979) this has not been observed invariably (Drexler et al, 1987;Biro et al, 1988), even in studies that did demonstrate a cerebral vasodilator response to (± )-dobutamine (Drexler et al, 1987). Although there was a greater hindquarters hyperaemia and a better maintenance of mesenteric blood flow during infusion of (+)-dobutamine than of human a-CGRP at either dose level, carotid hyperaemia was greater during infusion of the latter at the higher dose.…”

Section: Discussionmentioning

confidence: 83%

“…Vatner et al, 1974;Schoemaker, 1989;Dorszewski et al, 1990) often in anaesthetized or pithed animals (e.g. Robie & Goldberg, 1975;Ruffolo & Yaden, 1983;Ruffolo & Morgan, 1984;Maccarone et al, 1984;Ruffolo & Messick, 1985a,b;Biro et al, 1988). Furthermore, only incomplete data are available regarding the cardiovascular changes following the end of (±)-dobutamine infusion (Leier et al, 1977;1978).…”

Section: Introductionmentioning

confidence: 99%

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Differential effects of (±)‐dobutamine and human α‐CGRP on cardiac and on regional haemodynamics in conscious Long Evans rats

Gardiner

Compton

Kemp

et al. 1991

British J Pharmacology

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1 Comparisons were made of the full haemodynamic profiles of the known cardiostimulant, (± )-dobutamine, and the putative inotropic peptide, human a-calcitonin gene-related peptide (human a-CGRP), in conscious, chronically-instrumented Long Evans rats. Both substances were administered continuously i.v. for 60min at two doses ((±)-dobutamine, 2 and lOpmolkgr'h-i; human a-CGRP, 0.15 and 1.5 nmol kg1 h 1). 2 In spite of their similar (small) effects on mean arterial blood pressure, the low doses of (±)-dobutamine and human a-CGRP influenced cardiac haemodynamics differently. Thus, (±)-dobutamine caused an increase in cardiac index (due to a tachycardia), accompanied by rises in peak aortic flow, maximum rate of rise of aortic flow (dF/dtmai) and total peripheral conductance. However, the latter waned during the infusion, and after the infusion there was a significant systemic vasoconstriction and reductions in peak aortic flow, dF/dtmax and stroke index. Such 'off' effects following dobutamine infusion have not been described previously. The infusion of the lower dose of human cx-CGRP caused only a transient fall in central venous pressure.3 The rise in total peripheral conductance during infusion of the lower dose of (±)-dobutamine was associated with increases in hindquarters and common and internal carotid vascular conductances. The fall in total peripheral conductance after infusion was associated with renal vasoconstriction. Although there was no significant change in total peripheral conductance during the infusion of the lower dose of human a-CGRP there were hindquarters and carotid vasodilatations together with mesenteric vasoconstriction. 4 Infusion of the higher dose of ( )-dobutamine had greater effects than the lower dose on all cardiac haemodynamic variables and additionally, increased stroke index. However, the negative cardiac haemodynamic effects following the offset of infusion were also enhanced in association with marked renal and mesenteric vasoconstrictions. While infusion of the higher dose of human a-CGRP increased cardiac index, peak aortic flow, dF/dtmax and total peripheral conductance, stroke index fell together with central venous pressure. 5 (±)-Dobutamine caused greater cardiostimulation and increases in hindquarters blood flow than did human a-CGRP. However, the latter at the higher dose caused substantially greater common and internal carotid hyperaemia than did (±)-dobutamine, possibly indicating a selective and additional effect of human a-CGRP on cranial blood flow. Furthermore, there were no adverse cardiovascular effects following infusion of human a-CGRP.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Differential effects of (±)‐dobutamine and human α‐CGRP on cardiac and on regional haemodynamics in conscious Long Evans rats

Gardiner

Compton

Kemp

et al. 1991

British J Pharmacology

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“…In contrast, experimental studies have reported that dobutamine increases renal blood ow and reduces renal vascular resistance (26,27). In addition, the effect of dobutamine on renal function in different clinical settings has been very inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…Dobutamine increases cardiac output and oxygen delivery and is often used as part of this therapy (18,(21)(22)(23)(24). In addition to normal situations (25)(26)(27)(28), the renal effects of dobutamine have been studied during pathological conditions known to increase the risk of intestinal hypoperfusion such as septic shock (29)(30)(31)(32), heart failure (33,34), coronary artery bypass grafting and cardiopulmonary bypass (35), as well as after major vascular surgery (36). In these studies dobutamine has increased (26,27,37), decreased (31,32) or had no in uence (25,28,29) on renal blood ow and creatinine clearance.…”

Section: Introductionmentioning

confidence: 99%

Effects of Fluid and Dobutamine Treatment on Renal Function during Partial Superior Mesenteric Artery Occlusion and Reperfusion

Heino

Merasto

Koski

et al. 2002

Scandinavian Journal of Urology and Nephrology

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“…18,[20][21][22][23] Dopexamine, a synthetic analogue of dopamine, has a similar effect on renal blood flow and function. 24,25 Several studies have found an increase in splanchnic blood flow with dopexamine. 26,27 The aim of this study was to investigate the effects of dopamine and dopexamine on liver blood flow in the period immediately after cardiac surgery, and to compare these specific effects with haemodynamic changes in the systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

Enhancing liver blood flow after cardiopulmonary bypass: the effects of dopamine and dopexamine

et al. 1999

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Liver blood flow is reduced after cardiopulmonary bypass (CPB) and both dopamine and dopexamine are used to overcome this. This study compares the effects of these agents on liver blood flow. Thirty patients undergoing elective coronary artery bypass graft surgery were randomized into three groups (n = 10 per group). Six hours after surgery baseline liver blood flow was determined by the percentage disappearance rate of indocyanine green measured by dichromatic auricular densitometery. Patients then received infusions of either: (1) placebo (dextrose 5%); (2) dopamine (4 micrograms/kg/min); (3) dopexamine (1 microgram/kg/min increasing to 2 micrograms/kg/min). One hour after infusion, liver blood flow measurements were repeated. In the dopexamine group the infusion was increased and the measurements repeated another hour later. We found that patient-specific variables and operative details were similar for all groups. Postoperative cardiac index and heart rate were increased significantly by dopamine (cardiac index 2.82 +/- 0.46 l/m/m2 vs 3.28 +/- 0.67 l/m/m2: p < 0.001 and heart rate 87.5 +/- 13.2 vs 96 +/- 16: p < 0.05) and dopexamine at 2 micrograms/kg/min (cardiac index 2.71 +/- 0.53 l/m/m2 vs 3.45 +/- 0.67 l/m/m2: p < 0.05 and heart rate 89.0 +/- 18.9 vs 107.4 +/- 13.6: p < 0.001) compared to placebo (cardiac index 2.97 +/- 0.8 l/m/m2 vs 3.18 +/- 0.9 l/m/m2: p > 0.05 and heart rate 77.2 +/- 7.4 vs 77.3 +/- 8: p > 0.05) despite similar atrial and systemic arterial pressures. The disappearance rate of indocyanine green was not altered during infusion of placebo group (9.0 +/- 3.2%/min vs 7.9 +/- 3.0%/min: p > 0.05) or dopexamine at 1 microgram/kg/min (9.7 +/- 3.1%/min vs 11.2 +/- 4.1%/min: p > 0.05). The disappearance rate was increased with dopamine (6.7 +/- 3.7%/min vs 11.8 +/- 3.0%/min: p < 0.05) and dopexamine 2 micrograms/kg/min (9.7 +/- 3.1%/min vs 13.5 +/- 3.2%/min: p < 0.05). This indicates a 76% increase in liver blood flow with dopamine and a 38% increase with dopexamine. We conclude that dopamine 4 micrograms/kg/min and dopexamine 2 micrograms/kg/min increase liver blood flow, although this may, in part, be related to an increase in cardiac output. Dopexamine shows no advantage over dopamine in enhancing liver blood flow after CPB.

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Changes in regional blood flow distribution induced by infusions of dopexamine hydrochloride or dobutamine in anesthetized dogs

Cited by 35 publications

References 15 publications

Differential effects of (±)‐dobutamine and human α‐CGRP on cardiac and on regional haemodynamics in conscious Long Evans rats

Differential effects of (±)‐dobutamine and human α‐CGRP on cardiac and on regional haemodynamics in conscious Long Evans rats

Effects of Fluid and Dobutamine Treatment on Renal Function during Partial Superior Mesenteric Artery Occlusion and Reperfusion

Enhancing liver blood flow after cardiopulmonary bypass: the effects of dopamine and dopexamine

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